ID   IPI1_SCHPO              Reviewed;         413 AA.
AC   O94718;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Pre-rRNA-processing protein ipi1;
GN   Name=ipi1; ORFNames=SPCC1393.06c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of ipi1, rix1/ipi2 and
CC       crb3/ipi3 in a 1:2:2 stoichiometry. The complex interacts (via rix1)
CC       with mdn1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P38803}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38803}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR   EMBL; CU329672; CAB38162.2; -; Genomic_DNA.
DR   PIR; T40954; T40954.
DR   RefSeq; NP_587964.2; NM_001022955.3.
DR   AlphaFoldDB; O94718; -.
DR   SMR; O94718; -.
DR   BioGRID; 275817; 2.
DR   STRING; 4896.SPCC1393.06c.1; -.
DR   MaxQB; O94718; -.
DR   PaxDb; O94718; -.
DR   EnsemblFungi; SPCC1393.06c.1; SPCC1393.06c.1:pep; SPCC1393.06c.
DR   GeneID; 2539247; -.
DR   KEGG; spo:SPCC1393.06c; -.
DR   PomBase; SPCC1393.06c; ipi1.
DR   VEuPathDB; FungiDB:SPCC1393.06c; -.
DR   eggNOG; KOG2149; Eukaryota.
DR   HOGENOM; CLU_674656_0_0_1; -.
DR   InParanoid; O94718; -.
DR   OMA; HSGMTHI; -.
DR   PhylomeDB; O94718; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:O94718; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0000792; C:heterochromatin; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0097344; C:Rix1 complex; IDA:PomBase.
DR   GO; GO:0006364; P:rRNA processing; IMP:PomBase.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..413
FT                   /note="Pre-rRNA-processing protein ipi1"
FT                   /id="PRO_0000308729"
SQ   SEQUENCE   413 AA;  46919 MW;  5C827C8216AB04F5 CRC64;
     MGKSKKAKAK RADFNKQKLK VGKSKNAPNN FTDTSFRTKT LVLPTQAALE KEDFNTTAKD
     QAYFAHLLGM LKHHNANQRQ ETLEKLTQYV LSHTSILTTS TALLLKLTSP LILDESSSVR
     DCLYRFLEKF IYIMGPELLE PNIGMIFLYT HSGMTHITPS IRNDSTKFLS LLINACKDRL
     SSSAISLQWK KTLECFTNLL GWNSESASVK RTTSFSKKSS ANMIRHLTVC NDFLQLGLNP
     KLQAKNQQSS VHLKYPYLQQ CIVIHPKYEA FRSPCSFAYL SLFNPNKHDL VDNPTFRWQT
     IYPLIPGIIE FIRNSWSDAC PVVKDGSNSP SASKVCRTVL SMLGLFTEQV FSVADEPNNH
     RKKISQVLRK INRDIELINI NYGTDSEWRG VLKGYDKLRE RAVELDALEN PGK