ID   IPI3_ASHGO              Reviewed;         518 AA.
AC   Q75E14;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Pre-rRNA-processing protein IPI3;
GN   Name=IPI3; OrderedLocusNames=ABL141C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC   -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR   EMBL; AE016815; AAS50630.1; -; Genomic_DNA.
DR   RefSeq; NP_982806.1; NM_208159.1.
DR   AlphaFoldDB; Q75E14; -.
DR   SMR; Q75E14; -.
DR   STRING; 33169.AAS50630; -.
DR   EnsemblFungi; AAS50630; AAS50630; AGOS_ABL141C.
DR   GeneID; 4618886; -.
DR   KEGG; ago:AGOS_ABL141C; -.
DR   eggNOG; KOG0646; Eukaryota.
DR   HOGENOM; CLU_029749_4_0_1; -.
DR   InParanoid; Q75E14; -.
DR   OMA; YVWELNS; -.
DR   Proteomes; UP000000591; Chromosome II.
DR   GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR   GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0006267; P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication; IEA:EnsemblFungi.
DR   GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR045227; WDR18/Ipi3/RID3.
DR   PANTHER; PTHR18763; PTHR18763; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..518
FT                   /note="Pre-rRNA-processing protein IPI3"
FT                   /id="PRO_0000308736"
FT   REPEAT          73..123
FT                   /note="WD 1"
FT   REPEAT          127..166
FT                   /note="WD 2"
FT   REPEAT          175..220
FT                   /note="WD 3"
FT   REPEAT          226..267
FT                   /note="WD 4"
SQ   SEQUENCE   518 AA;  56115 MW;  0A35CDB92290E3A7 CRC64;
     MDEQVIFTTA VSGTVCQVHS VGQANLRQCA ASTPNSAVLM GDKLLVAQAN KALINVYSVD
     SRSKKEALEQ RLPLPEQLSC LAVVENHTGD AGVHQQLPYL LLGSTPSGKL YVWEAGSGKL
     LTVKAMAHYQ AITKMQAIIN GKYVVTAGAD SRLIIWQTAS LVLEEEPKPL YVLHDHTLAI
     TDFAVSNAHN GKYLNSKLYT VSEDMTVRCY QLSSQLEQPQ LLATFTFPLA LTSIALDPAD
     RCLYVGTREG AFALPLFYKL DSSGATLVNL LQPGKHQIYS IVPEQAGVEV NKQELYRMGQ
     LLCSKMLSCH VSLIRVSMDG SMVLLATGSG NCVVVDTYSK QPVKELAPLL APGTQTGPVS
     NIITRSMTVK SDSLLQDLNL ADARATEAIK IPALAKTVFD KTGTHDIIYC APTDTLSSVL
     PRALDLPQYL DMIAEEDSVF ANTPVTRSTV KVVGELAPAK AEALPASSAE AQQSADDTDA
     EVARLRESLQ QLTGAYKDLR ALHEKLYEEH EKLLQTSK