ID   IPI3_CANAL              Reviewed;         505 AA.
AC   Q5AB15; Q5AAS6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Pre-rRNA-processing protein IPI3;
GN   Name=IPI3; OrderedLocusNames=CAALFM_C106760CA;
GN   ORFNames=CaO19.13614, CaO19.6234;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC   -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR   EMBL; CP017623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5AB15; -.
DR   SMR; Q5AB15; -.
DR   BioGRID; 1222599; 1.
DR   STRING; 237561.Q5AB15; -.
DR   eggNOG; KOG0646; Eukaryota.
DR   HOGENOM; CLU_029749_4_0_1; -.
DR   InParanoid; Q5AB15; -.
DR   PRO; PR:Q5AB15; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR   GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR045227; WDR18/Ipi3/RID3.
DR   PANTHER; PTHR18763; PTHR18763; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..505
FT                   /note="Pre-rRNA-processing protein IPI3"
FT                   /id="PRO_0000308737"
FT   REPEAT          106..145
FT                   /note="WD 1"
FT   REPEAT          148..187
FT                   /note="WD 2"
FT   REPEAT          201..244
FT                   /note="WD 3"
FT   REPEAT          321..362
FT                   /note="WD 4"
SQ   SEQUENCE   505 AA;  55944 MW;  72346EBA6473C56C CRC64;
     MDEVVFYIAQ GDPADKHSQE SYGYVTSIHS SKQYASYRQA DSHINGTAIT GIGPGERIFT
     AVPNKALINV YSWGKESVDQ RIPIPEALTC ITLINHPNGS NNNSDNDDNQ LYKLPNYRVP
     WLLAGGSKSG KLYIWELSSG NLLCVRDAHY QGITTIKGSS CGTFLITGGE DARCLVWNLA
     ELISIYDKSD HQVKPYWQIT DNTLPLTDLC LNDTHNINDL KLYTTSEDST VRIYDIVTKS
     LLTTFILPSS AECITKDPAN RALYVGLNNG LVRSIPLYSI NSHTSVLESI GGMNKIITVD
     ADQNLKETFV AHQQKTKTGD DKPVVVTKLT ISFDGTSIIS GDSEGRVFVS DIVTKQVVKS
     FTPCNSPIAY IAVETVPDDF VNNLATSTTT NKADKKHRMI PQFKRVLAST NSEEHQIFLD
     IPGKTTATTN ATGNIDFATW LQSKQSEELQ FKNLSGINSI VKQVGNENVS DLEEKLQRVS
     QAYTELRNKH EELIKEHAKL LDKLE