ID   IPI3_CANGA              Reviewed;         528 AA.
AC   Q6FNJ1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Pre-rRNA-processing protein IPI3;
GN   Name=IPI3; OrderedLocusNames=CAGL0J11286g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC   -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR   EMBL; CR380956; CAG61154.1; -; Genomic_DNA.
DR   RefSeq; XP_448203.1; XM_448203.1.
DR   AlphaFoldDB; Q6FNJ1; -.
DR   SMR; Q6FNJ1; -.
DR   STRING; 5478.XP_448203.1; -.
DR   EnsemblFungi; CAG61154; CAG61154; CAGL0J11286g.
DR   GeneID; 2889493; -.
DR   KEGG; cgr:CAGL0J11286g; -.
DR   CGD; CAL0133448; CAGL0J11286g.
DR   VEuPathDB; FungiDB:CAGL0J11286g; -.
DR   eggNOG; KOG0646; Eukaryota.
DR   HOGENOM; CLU_029749_4_0_1; -.
DR   InParanoid; Q6FNJ1; -.
DR   OMA; YVWELNS; -.
DR   Proteomes; UP000002428; Chromosome J.
DR   GO; GO:0005656; C:nuclear pre-replicative complex; IEA:EnsemblFungi.
DR   GO; GO:0097344; C:Rix1 complex; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0006267; P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication; IEA:EnsemblFungi.
DR   GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR045227; WDR18/Ipi3/RID3.
DR   PANTHER; PTHR18763; PTHR18763; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..528
FT                   /note="Pre-rRNA-processing protein IPI3"
FT                   /id="PRO_0000308738"
FT   REPEAT          79..126
FT                   /note="WD 1"
FT   REPEAT          130..169
FT                   /note="WD 2"
FT   REPEAT          188..227
FT                   /note="WD 3"
FT   REPEAT          249..290
FT                   /note="WD 4"
SQ   SEQUENCE   528 AA;  59351 MW;  5E8107FA7251D9E3 CRC64;
     MDESVIFTTE QNALSTSLYS AEQAVLRQCS TNSRNSAVRV GDKYLFVAQS NKALINVYNI
     SGAHKRETVE QRLPTPEVIT CLEVIQNRYE EKSAISDFEL PHLLLGSTDG GKIYCWELNS
     GALLSVKQMA HYQGITKIKS FMDGKYFITS GKDSRVIVWQ TIDFVSNNAS EPKPICILHD
     HNLTVNDIAV SMTHGANMST SGAKLFTASE DSTVRCYDFS FLRGDFRKNR KSQEQDQKMY
     QPRLLATFTF PAAIEAMSLD PADRALYVGT SEGLFSLPLY YTVKGTSTVA NLAQASGSNR
     NKLYSVVISG HDDDYKKLFS MGQLVCDKLI STPVTKLELT FDATTILVGN KFGRISVVEI
     ASKQILKTLQ PLTTADTEED AITNIIVTTV NNSRQDSILE QHQSNKNVQK LPVLQRVVHD
     KDHAEHEVWY RAPETPEFSH ELESLPPIAD FEKYMDSIRS EETVFLTTET TSQVKNVKQE
     LAPASHSNSQ EQQELQQELQ QVKSAYKELR ELHESLFKEH EQLLSSMK