IPI3_DEBHA
ID IPI3_DEBHA Reviewed; 515 AA.
AC Q6BMP5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Pre-rRNA-processing protein IPI3;
GN Name=IPI3; OrderedLocusNames=DEHA2F03674g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC particles. {ECO:0000250|UniProtKB:P53877}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR EMBL; CR382138; CAG88840.2; -; Genomic_DNA.
DR RefSeq; XP_460526.2; XM_460526.1.
DR AlphaFoldDB; Q6BMP5; -.
DR SMR; Q6BMP5; -.
DR STRING; 4959.XP_460526.2; -.
DR EnsemblFungi; CAG88840; CAG88840; DEHA2F03674g.
DR GeneID; 2903431; -.
DR KEGG; dha:DEHA2F03674g; -.
DR VEuPathDB; FungiDB:DEHA2F03674g; -.
DR eggNOG; KOG0646; Eukaryota.
DR HOGENOM; CLU_029749_4_0_1; -.
DR InParanoid; Q6BMP5; -.
DR OMA; YVWELNS; -.
DR OrthoDB; 747023at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR045227; WDR18/Ipi3/RID3.
DR PANTHER; PTHR18763; PTHR18763; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..515
FT /note="Pre-rRNA-processing protein IPI3"
FT /id="PRO_0000308739"
FT REPEAT 104..143
FT /note="WD 1"
FT REPEAT 146..185
FT /note="WD 2"
FT REPEAT 202..245
FT /note="WD 3"
FT REPEAT 334..375
FT /note="WD 4"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 57146 MW; F788333BB14B7B8A CRC64;
MDESVFYISE GDPADKHSQE SFGHSSSVHS SQQHAGFRQA DCPQNGACLS GVGTGERLFV
ASPNKALINV YSWGKESPDQ RIPIPEQLSC LTLCKHPRIK VSEGRQSDER NLPSFRTPWL
LAGGSKTGKI YVWELASGNL LCVKEAHYQA ITAIKFSQCG TFLVSGSSDA RCMVWRTSDL
ISVYNKDEES SINIKPFASF TDHSLPITDL AISEAGIISD LRLYTVSRDS TLRIYDIMTK
SLLTTFVLPS GIECVTKDPA NRACYVGLSN GLIRTVPLYQ INPNTSVLES IGGRGKIVTL
DTDPNLLSTF VHHQQRLSTE PLHKTLNKKT TTEEKPILVT RLSITMDGSN LISGDSAGRV
YVSDIVSRQV VKTFAPCKSS ISYIQVNACA AEKVSVSNTS SNNNDKRHRL IPQFKRVLAN
PDPLEHQLYM EIPKQQEDEE DFESWLARKS QEELEFRNLT HINSSVTVTG AAPTTNDSTV
KELEEKLAKV SKAYTDLRGK HEELYEEHNR LLSDS
