ID   IPI3_KLULA              Reviewed;         508 AA.
AC   Q6CRK4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Pre-rRNA-processing protein IPI3;
GN   Name=IPI3; OrderedLocusNames=KLLA0D08371g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC   -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382124; CAH00531.1; -; Genomic_DNA.
DR   RefSeq; XP_453435.1; XM_453435.1.
DR   AlphaFoldDB; Q6CRK4; -.
DR   SMR; Q6CRK4; -.
DR   STRING; 28985.XP_453435.1; -.
DR   EnsemblFungi; CAH00531; CAH00531; KLLA0_D08371g.
DR   GeneID; 2893425; -.
DR   KEGG; kla:KLLA0_D08371g; -.
DR   eggNOG; KOG0646; Eukaryota.
DR   HOGENOM; CLU_029749_4_0_1; -.
DR   InParanoid; Q6CRK4; -.
DR   OMA; YVWELNS; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005656; C:nuclear pre-replicative complex; IEA:EnsemblFungi.
DR   GO; GO:0097344; C:Rix1 complex; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0006267; P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication; IEA:EnsemblFungi.
DR   GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR045227; WDR18/Ipi3/RID3.
DR   PANTHER; PTHR18763; PTHR18763; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..508
FT                   /note="Pre-rRNA-processing protein IPI3"
FT                   /id="PRO_0000308740"
FT   REPEAT          74..113
FT                   /note="WD 1"
FT   REPEAT          117..156
FT                   /note="WD 2"
FT   REPEAT          214..255
FT                   /note="WD 3"
FT   REPEAT          289..326
FT                   /note="WD 4"
SQ   SEQUENCE   508 AA;  56345 MW;  8A6686E0D79A46BC CRC64;
     MDEQVIFTSN TAGTVATLHS LEQSSLRQCQ TESKFSSCVV KQKYLFVAQS RKALIQVYDL
     HGSNKRESVE QRLPVPEVLQ ALECVDEDGL LLGATDSGKL YIWQLASGNL LNVKPMAHYQ
     GIVKIKSICH GKYIVTAGSD SRLIFWQTMD LVQKDEPKPL FIIHDHSLPV TDFIFSNTLG
     HSLDGKLYTV SKDMSLRCYQ VSVDHEPTCI ATFTFPSSLN CVSLDTADRA IYVGTDTGVI
     QIPLYYKVSN SKIINLLQPN ESKIYSITEI TPGAMEPDLS SREKLFSIGQ ILCARIVHNN
     TTSVATSLDG SLLVSGDSTG KCTVTEIFSN QPLKEIRALS TNDSTGPVSN LIVFPVTQQS
     ESLLDVTKIV KPWKFPNLQR AIVDRKHGIN DVYVQFHENS VHNVLPVSDF DSYLDTVASE
     EHIFHQTGSI NSTVNRVGQT KASMTATAKE SKVSSDDDIY KSKDKQIAQL NGTVASLTDA
     YKELRKMHED LMKEHQQLLS KNGTQTEN