ID   IPI3_LODEL              Reviewed;         521 AA.
AC   A5DTA8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Pre-rRNA-processing protein IPI3;
GN   Name=IPI3; ORFNames=LELG_00594;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC   -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR   EMBL; CH981524; EDK42416.1; -; Genomic_DNA.
DR   RefSeq; XP_001528074.1; XM_001528024.1.
DR   AlphaFoldDB; A5DTA8; -.
DR   SMR; A5DTA8; -.
DR   STRING; 379508.A5DTA8; -.
DR   EnsemblFungi; EDK42416; EDK42416; LELG_00594.
DR   GeneID; 5234716; -.
DR   KEGG; lel:LELG_00594; -.
DR   VEuPathDB; FungiDB:LELG_00594; -.
DR   eggNOG; KOG0646; Eukaryota.
DR   HOGENOM; CLU_029749_4_0_1; -.
DR   InParanoid; A5DTA8; -.
DR   OMA; YVWELNS; -.
DR   OrthoDB; 747023at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR045227; WDR18/Ipi3/RID3.
DR   PANTHER; PTHR18763; PTHR18763; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..521
FT                   /note="Pre-rRNA-processing protein IPI3"
FT                   /id="PRO_0000308741"
FT   REPEAT          106..151
FT                   /note="WD 1"
FT   REPEAT          154..193
FT                   /note="WD 2"
FT   REPEAT          219..262
FT                   /note="WD 3"
FT   REPEAT          321..361
FT                   /note="WD 4"
SQ   SEQUENCE   521 AA;  57673 MW;  8AAEBE6707AA1615 CRC64;
     MDEVLFYVSA GDQSDTKKPA ESFAYISSIH SSKQYETFRH AASPLNGTAI SGVGLGERIF
     TSDNKKALVN VYTYGKESID QRIPIPEALT ALHIIHHPTL PHGAEAKGEE FENSLATHDK
     PNYRVPWLLC GGSKLGKLYI WELASGDLLC VKEAHYQGIT RIDLSLCGTF LVTGGEDARI
     MVWNLADLIA IYGQAGLINE TDSSSTVNRS GKPYYSITDN TLPITDFTLN QVGNLADLKL
     YTASKDSTVR IYDITTKQQL TTFILPQPVT CLARDPANRQ LYAGLANGLI KTIPLYKFNQ
     HTSVLEAVGG LDRIITVDQE DPNMLSTFVQ HENHKVTKLC VSMDGTNLIS GDDAGQVFVS
     DIATKQTIKS FPSLNFPISD LYVETVPVDL LVNDKIRTDK KHRMMPPLKR VLASADPVDH
     VLFMDIPQES VNTIISTKVH KDLDWLEKKK MEELLFKNLS DVNSTVKTID TGANGGHNQQ
     STANLELKLS KVSEAYTDLR SKHEQLIKEH AKLLDKLAEG K