ID   IPI3_PICGU              Reviewed;         451 AA.
AC   A5DNK9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Pre-rRNA-processing protein IPI3;
GN   Name=IPI3; ORFNames=PGUG_04860;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC   -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR   EMBL; CH408160; EDK40762.2; -; Genomic_DNA.
DR   RefSeq; XP_001482905.1; XM_001482855.1.
DR   AlphaFoldDB; A5DNK9; -.
DR   SMR; A5DNK9; -.
DR   STRING; 4929.XP_001482905.1; -.
DR   PRIDE; A5DNK9; -.
DR   EnsemblFungi; EDK40762; EDK40762; PGUG_04860.
DR   GeneID; 5124836; -.
DR   KEGG; pgu:PGUG_04860; -.
DR   VEuPathDB; FungiDB:PGUG_04860; -.
DR   eggNOG; KOG0646; Eukaryota.
DR   HOGENOM; CLU_029749_4_0_1; -.
DR   InParanoid; A5DNK9; -.
DR   OMA; GHIRIIN; -.
DR   OrthoDB; 747023at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR045227; WDR18/Ipi3/RID3.
DR   PANTHER; PTHR18763; PTHR18763; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..451
FT                   /note="Pre-rRNA-processing protein IPI3"
FT                   /id="PRO_0000308742"
FT   REPEAT          89..129
FT                   /note="WD 1"
FT   REPEAT          132..171
FT                   /note="WD 2"
FT   REPEAT          185..227
FT                   /note="WD 3"
FT   REPEAT          229..271
FT                   /note="WD 4"
FT   REGION          408..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   451 AA;  49453 MW;  73390E2AB37360C2 CRC64;
     MDESILYVPA GPEGSALAAS LHSTRQNAAF RYADSKFLSA VCSGQKAGDR LFLAGSKPLI
     TVYSWGKESP DQRIPVPEPL TCMALCKHPS NEKINHKVPT FQLPWLLAGG SASGKLYIWE
     LSSGNLVCVK EAHYQAINVL KFSECGTYLV SGGADARCSV WKTLDLVTID DPETQKTASA
     LTFMDHTLAV TDIWLTTGIR SDIRLYSSSK DGTVRNYDIT SGKLITTFVL PLSVECLAVD
     PAGRACYAGL SDGTIRTVLQ YKVNPHTSVL EAVGGNGKVV TLATDPELRE SFVHHQPHRV
     TSVKVSLDGT TIISSDESGR VMVADAVTTQ VVKALSPATS PVIYLAVDTV VAGSQFGRFE
     KKHRLIPQLK RVLVDGDLTK HFVSMEFSEE IKPQPDFDLW LQQKAEEARE VEEEKPKQKE
     QDSETEKLAK LTKAYGDLRQ KHEQLLREMS A