IPI3_PICST
ID IPI3_PICST Reviewed; 525 AA.
AC A3LNM0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Pre-rRNA-processing protein IPI3;
GN Name=IPI3; ORFNames=PICST_41524;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC particles. {ECO:0000250|UniProtKB:P53877}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR EMBL; CP000496; ABN64353.2; -; Genomic_DNA.
DR RefSeq; XP_001382382.2; XM_001382345.1.
DR AlphaFoldDB; A3LNM0; -.
DR SMR; A3LNM0; -.
DR STRING; 4924.XP_001382382.2; -.
DR EnsemblFungi; ABN64353; ABN64353; PICST_41524.
DR GeneID; 4837183; -.
DR KEGG; pic:PICST_41524; -.
DR eggNOG; KOG0646; Eukaryota.
DR HOGENOM; CLU_029749_4_0_1; -.
DR InParanoid; A3LNM0; -.
DR OMA; YVWELNS; -.
DR OrthoDB; 747023at2759; -.
DR Proteomes; UP000002258; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR045227; WDR18/Ipi3/RID3.
DR PANTHER; PTHR18763; PTHR18763; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..525
FT /note="Pre-rRNA-processing protein IPI3"
FT /id="PRO_0000308743"
FT REPEAT 105..144
FT /note="WD 1"
FT REPEAT 147..186
FT /note="WD 2"
FT REPEAT 204..247
FT /note="WD 3"
FT REPEAT 326..374
FT /note="WD 4"
SQ SEQUENCE 525 AA; 58114 MW; 4D7FC061915768FD CRC64;
MDESVFYIAE GDPNDKHSQE SFALATSIHN SQQHASFRQA DAPKNGAILS GSGQGERLIV
AAPNKALLNV YSWGKESPDQ RIPLPEALTC LALVEHPNTR LFSEFHRNSE FKLPSYRVPW
LLAGGSKSGK IYVWELSSGS LLCVKEAHYQ NVTVVKFSKC GTFLVAGSDD ARCTVWKTLD
LIAVFDGDND ESSRNFKPYL AITDNTLAVT DLVLNEPGVI NDLKLYTVSR DNTLRIYDII
TKQLLTTFIL SEAIESVVAD PAGRAVYVGL SNGLIRTIPL YNINPNTSVL ESIGGNQKII
TVESDPNLKF TFLHHQQRIS ADANKTSILH KNLNNKKNDT ENANKPIHVT KLAISLDGTN
LISGDSLGRV YVSDIVTRQV VKTFTPCNSP ISQIQVSSAP FEALNVSSNS KVDKKHRLIP
QLKRVLTGRD ATEHQLNLEI PSESRDESDE NFAVWLSRKT QEDLEFKNLS GVNSSVKKVA
NITSDSESKK ELEDKLAKLS SAYTQLRSKH EELLKEHSKV LNNKA
