IPI3_USTMA
ID IPI3_USTMA Reviewed; 587 AA.
AC Q4PHV3; A0A0D1CFV0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Pre-rRNA-processing protein IPI3;
GN Name=IPI3; ORFNames=UMAG_00310;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC particles. {ECO:0000250|UniProtKB:P53877}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
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DR EMBL; CM003140; KIS71882.1; -; Genomic_DNA.
DR RefSeq; XP_011386219.1; XM_011387917.1.
DR AlphaFoldDB; Q4PHV3; -.
DR SMR; Q4PHV3; -.
DR STRING; 5270.UM00310P0; -.
DR EnsemblFungi; KIS71882; KIS71882; UMAG_00310.
DR GeneID; 23561652; -.
DR KEGG; uma:UMAG_00310; -.
DR VEuPathDB; FungiDB:UMAG_00310; -.
DR eggNOG; KOG0646; Eukaryota.
DR HOGENOM; CLU_029749_4_0_1; -.
DR InParanoid; Q4PHV3; -.
DR OMA; AINDEMW; -.
DR OrthoDB; 747023at2759; -.
DR Proteomes; UP000000561; Chromosome 1.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR045227; WDR18/Ipi3/RID3.
DR PANTHER; PTHR18763; PTHR18763; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..587
FT /note="Pre-rRNA-processing protein IPI3"
FT /id="PRO_0000308744"
FT REPEAT 101..142
FT /note="WD 1"
FT REPEAT 144..182
FT /note="WD 2"
FT REPEAT 203..246
FT /note="WD 3"
FT REPEAT 353..392
FT /note="WD 4"
SQ SEQUENCE 587 AA; 62336 MW; 40E7AE361926D5F9 CRC64;
MASSSSAASL FATECLLYST ASSSTLVGSM GLTTVAAPSS TSALFTFKGV SDPAFHSVTV
IPTSPNPAIS GTGGLIFQLE SNKAALNIFS WQRDHLLQRI ILPSKLSCIA CSPNGDLVAG
GSFDGRILLW QIATGDLLAS FDAHYRSVTV LKWTCDGAGL LTGSEDARIL VWSLAGLLAP
HDQTSSSITS SEHNPAPYCT LADHNLAITD LDISSGRFPH QAMVLSSSSD ASVKLWDLRT
RSLLSTFVFE QPIHRVVLDC TERFFFAATA PTSSDNLVYR IDLFRKRDAS SRMVETKQAT
TGSQFDFVTD ELRGASSVEA HGFGSAAGPT TERIPSARDV AHRAESNGSS IISIREPISS
MCLSTNSTSL LVGSVAGNLF VIDVSNSQVV RTVSLLGNAK VSAISDKNAV TNLMVLPKPR
DLLGHWETLS SSGTGSSMSG SGGVGGAGAP VGIPVRPIAS SFGHHVLASE EDRLSKPYLT
RISGNKTTLA FDEHNVDSFI DPEWDSHLVS SELLGRSTSA LLSPSQTQSG APPSTSAIHA
QAALEAERLQ RENKLLRSQL HQAKAINDEM WSRLVQDRLS VNQVDSE
