ID   IPI3_YARLI              Reviewed;         426 AA.
AC   Q6C953;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Pre-rRNA-processing protein IPI3;
GN   Name=IPI3; OrderedLocusNames=YALI0D13948g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the RIX1 complex required for processing of ITS2
CC       sequences from 35S pre-rRNA. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBUNIT: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and
CC       IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with
CC       MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:P53877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53877}.
CC   -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382130; CAG80997.1; -; Genomic_DNA.
DR   RefSeq; XP_502809.1; XM_502809.1.
DR   AlphaFoldDB; Q6C953; -.
DR   SMR; Q6C953; -.
DR   STRING; 4952.CAG80997; -.
DR   EnsemblFungi; CAG80997; CAG80997; YALI0_D13948g.
DR   GeneID; 2910269; -.
DR   KEGG; yli:YALI0D13948g; -.
DR   VEuPathDB; FungiDB:YALI0_D13948g; -.
DR   HOGENOM; CLU_029749_4_0_1; -.
DR   InParanoid; Q6C953; -.
DR   OMA; VNARIYT; -.
DR   Proteomes; UP000001300; Chromosome D.
DR   GO; GO:0000792; C:heterochromatin; IEA:EnsemblFungi.
DR   GO; GO:0005656; C:nuclear pre-replicative complex; IBA:GO_Central.
DR   GO; GO:0097344; C:Rix1 complex; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR045227; WDR18/Ipi3/RID3.
DR   PANTHER; PTHR18763; PTHR18763; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW   WD repeat.
FT   CHAIN           1..426
FT                   /note="Pre-rRNA-processing protein IPI3"
FT                   /id="PRO_0000308745"
FT   REPEAT          75..114
FT                   /note="WD 1"
FT   REPEAT          117..154
FT                   /note="WD 2"
FT   REPEAT          164..206
FT                   /note="WD 3"
FT   REPEAT          269..308
FT                   /note="WD 4"
SQ   SEQUENCE   426 AA;  46240 MW;  F367D7F3A3CF51CE CRC64;
     MEELIIYTTN KGACAVDLHS GNNITHFKND ETAPNLSVFL TNTPSGNPLL FSAQTKGAMM
     HVYNWNRESV DQQIVLPEKL SCLAASTCGT WLAGGSASGR LFVWELASGK LVFSREVHYQ
     AVTKLAFTDG LLFSTSKDAR VLGWSLVTMA SDPKDCQPCI TWTEHNLGVV DLVVGGGPTR
     DTRVFTVSTD KTVRIWDVSS TALLTTITLP AAETPTTLAV DQLERTLFVG CASGNILSVS
     LYDVSPSTGL VSVGGASGVV ESGNVALSHH KSAVTSLALS FDATLLVSAD DKGFICVWDL
     PSRQVSRSIK QPRAEMNPVT YVQTITTHGL PTEKYNPKTA VKLPMLKRVQ DDKPEDHDIL
     VKIQPRQKTV AHEDTLQQMV ESAQFGGDSL AGKVVQLENE LSQAKSSFAS LKESHDTLWN
     IYQRQQ