ID   IPIL1_MOUSE             Reviewed;         547 AA.
AC   A2ASA8; A1L3P2; B7ZCY2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1;
DE   Flags: Precursor;
GN   Name=Itpripl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ITPRIP family. {ECO:0000305}.
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DR   EMBL; AL928590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC130218; AAI30219.1; -; mRNA.
DR   CCDS; CCDS50701.1; -.
DR   RefSeq; NP_001156999.1; NM_001163527.1.
DR   RefSeq; NP_001157000.1; NM_001163528.1.
DR   AlphaFoldDB; A2ASA8; -.
DR   STRING; 10090.ENSMUSP00000106016; -.
DR   PhosphoSitePlus; A2ASA8; -.
DR   EPD; A2ASA8; -.
DR   MaxQB; A2ASA8; -.
DR   PaxDb; A2ASA8; -.
DR   PRIDE; A2ASA8; -.
DR   ProteomicsDB; 269076; -.
DR   Antibodypedia; 3069; 106 antibodies from 19 providers.
DR   Ensembl; ENSMUST00000110386; ENSMUSP00000106016; ENSMUSG00000074825.
DR   Ensembl; ENSMUST00000154021; ENSMUSP00000122289; ENSMUSG00000074825.
DR   GeneID; 73338; -.
DR   KEGG; mmu:73338; -.
DR   UCSC; uc008meu.2; mouse.
DR   CTD; 150771; -.
DR   MGI; MGI:1920588; Itpripl1.
DR   VEuPathDB; HostDB:ENSMUSG00000074825; -.
DR   eggNOG; ENOG502RX8U; Eukaryota.
DR   GeneTree; ENSGT01050000244827; -.
DR   HOGENOM; CLU_025485_2_0_1; -.
DR   InParanoid; A2ASA8; -.
DR   OMA; HLQLEDC; -.
DR   OrthoDB; 1434451at2759; -.
DR   PhylomeDB; A2ASA8; -.
DR   TreeFam; TF332277; -.
DR   BioGRID-ORCS; 73338; 1 hit in 72 CRISPR screens.
DR   PRO; PR:A2ASA8; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; A2ASA8; protein.
DR   Bgee; ENSMUSG00000074825; Expressed in seminiferous tubule of testis and 68 other tissues.
DR   ExpressionAtlas; A2ASA8; baseline and differential.
DR   Genevisible; A2ASA8; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR024808; IP3R-int-like_1.
DR   InterPro; IPR026250; ITPRIP_fam.
DR   InterPro; IPR024810; Mab-21_dom.
DR   PANTHER; PTHR10656:SF40; PTHR10656:SF40; 1.
DR   Pfam; PF03281; Mab-21; 1.
DR   PRINTS; PR02107; INOS145TPRIP.
DR   SMART; SM01265; Mab-21; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..547
FT                   /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT                   protein-like 1"
FT                   /id="PRO_0000320567"
FT   TOPO_DOM        23..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..547
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   COILED          28..66
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   547 AA;  62217 MW;  D0BF812ECBA91CAA CRC64;
     MAVISLMFLA VMYVVHHPLM VSDRMDLDTL ARSRQLEKRM SEEMRQLEME FEERSRAAEQ
     KQKVENFWRG DTSSDQLVLG KKDMGWPFQA GGQDGGPLGW ILGNLWNAGL FCLFLIFELL
     RQSMQHEPAF ESSSEEEEEE IRVVPVSSYT RLSDFPSQEA LEAFYKHYIQ NAIRDLPCTC
     EFVESFVDDL IEACRVLSRR EAHPQLEDCL GFGAAFEKWG TLHETQNFDV LVPIVPPQGT
     MFILEMRDPA LGRRCGCVKV DSECMCKHEK LLGDVLCLVH HRDHSAMLSK CTSSIKAALC
     TSSHLDVCKT VQWFRNMVSN AWALVAHKYD FKLTFPPSTT SCKLRLGYRS GRSLSISLVL
     GVQREDTLVY LVSQAPEQEQ LTSVDWPESF AACEHLFLKL VGRFAPENTC HLKCLQIVLS
     LQDHQILPPG ASRPILTSYH FKTALMHLLL RLPLTDWQHS MLSLRLQDLL WFLGRGLQQR
     SLHHFLIGNT YLPLTIPIPK AFRNAEPVNL FQHLVLNPVA HSQAVEEFHN LLAQVKTLPC
     SPVAGGL