IPIL2_MOUSE
ID IPIL2_MOUSE Reviewed; 535 AA.
AC Q3UV16; B2RX24; Q3UE60;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2;
DE Flags: Precursor;
GN Name=Itpripl2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the ITPRIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE29051.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK137678; BAE23457.1; -; mRNA.
DR EMBL; AK149729; BAE29051.1; ALT_FRAME; mRNA.
DR EMBL; BC150856; AAI50857.1; -; mRNA.
DR EMBL; BC150864; AAI50865.1; -; mRNA.
DR CCDS; CCDS52373.1; -.
DR RefSeq; NP_001028552.1; NM_001033380.3.
DR AlphaFoldDB; Q3UV16; -.
DR STRING; 10090.ENSMUSP00000136409; -.
DR PhosphoSitePlus; Q3UV16; -.
DR MaxQB; Q3UV16; -.
DR PaxDb; Q3UV16; -.
DR PRIDE; Q3UV16; -.
DR ProteomicsDB; 269077; -.
DR Antibodypedia; 62727; 26 antibodies from 10 providers.
DR Ensembl; ENSMUST00000178344; ENSMUSP00000136409; ENSMUSG00000095115.
DR GeneID; 319622; -.
DR KEGG; mmu:319622; -.
DR UCSC; uc009jjx.1; mouse.
DR CTD; 162073; -.
DR MGI; MGI:2442416; Itpripl2.
DR VEuPathDB; HostDB:ENSMUSG00000095115; -.
DR eggNOG; ENOG502QT2J; Eukaryota.
DR GeneTree; ENSGT01050000244827; -.
DR HOGENOM; CLU_043756_0_0_1; -.
DR InParanoid; Q3UV16; -.
DR OMA; QRTQGFP; -.
DR OrthoDB; 835491at2759; -.
DR PhylomeDB; Q3UV16; -.
DR TreeFam; TF332277; -.
DR BioGRID-ORCS; 319622; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Itpripl2; mouse.
DR PRO; PR:Q3UV16; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3UV16; protein.
DR Bgee; ENSMUSG00000095115; Expressed in molar tooth and 176 other tissues.
DR Genevisible; Q3UV16; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR024798; IP3R-int-like_2.
DR InterPro; IPR026250; ITPRIP_fam.
DR InterPro; IPR024810; Mab-21_dom.
DR PANTHER; PTHR10656:SF9; PTHR10656:SF9; 1.
DR Pfam; PF03281; Mab-21; 1.
DR PRINTS; PR02107; INOS145TPRIP.
DR SMART; SM01265; Mab-21; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..535
FT /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT protein-like 2"
FT /id="PRO_0000336094"
FT TOPO_DOM 33..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..535
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 139
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3MIP1"
FT CONFLICT 200
FT /note="T -> H (in Ref. 1; BAE29051)"
FT /evidence="ECO:0000305"
FT CONFLICT 525..527
FT /note="QRI -> RRM (in Ref. 1; BAE29051)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 535 AA; 58665 MW; 4D18BE17506F324B CRC64;
MSVRYTLNLR VFWPLVTGLC TALVCLYHAL RSSEDARAES PDGADSGFPL LKVAILLLLG
YILLRCRHAI RQRLLPGSSR PRGHANFSAR SLQEPGLSIL LESYYEHEVR LSPHVLGHSK
AHVSRIVGEL VQAGRARGSP GLITGGALAL AFRGDFIQVG SAYEQHKIRR PDSFDVLVPL
RLPPQVALEP RSLGTEPSLT PAFRSCFVCA LKAPPSPSGA STGQWHRDCK PFAEGFCVDV
QGRRHLSATL VLRWFQAHLQ RSLATVRYSL EGRCRVSLTP GSLEQPPTLH ILPCRTDYGC
CRLSMAVRLI PAVHLGDGVF LVAPPPPPSP SGALSELPGG LRAEALWGVN TARQEQKLLG
WLQERAPPGA CYLKCLQLLK ALRDLGARGL DPMAATHWGR ILSSYVLKTA VLEVLLNEGS
PTPSWDEAHL SECLEKLVKF LRDCLLRRRD LFHCVLGPTG AAAEVGPLPK VLREAAPVDL
LAPFDPHSRE LAAARLLSTW RRLPQLLRVY GGPRYLARCP APRSQRIQGS PEDEP
