ID   IPK1_CANGA              Reviewed;         278 AA.
AC   Q6FRN1;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Inositol-pentakisphosphate 2-kinase;
DE            EC=2.7.1.158;
DE   AltName: Full=Inositol-1,3,4,5,6-pentakisphosphate 2-kinase;
DE   AltName: Full=Ins(1,3,4,5,6)P5 2-kinase;
DE            Short=InsP5 2-kinase;
GN   Name=IPK1; OrderedLocusNames=CAGL0H07271g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Has kinase activity and phosphorylates inositol-1,3,4,5,6-
CC       pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-
CC       hexakisphosphate (InsP6), also known as phytate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-
CC         inositol hexakisphosphate + ADP + H(+); Xref=Rhea:RHEA:20313,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733,
CC         ChEBI:CHEBI:58130, ChEBI:CHEBI:456216; EC=2.7.1.158;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The EXKPK motif is conserved in inositol-pentakisphosphate 2-
CC       kinases of both family 1 and 2.
CC   -!- SIMILARITY: Belongs to the IPK1 type 1 family. {ECO:0000305}.
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DR   EMBL; CR380954; CAG60046.1; -; Genomic_DNA.
DR   RefSeq; XP_447113.1; XM_447113.1.
DR   AlphaFoldDB; Q6FRN1; -.
DR   SMR; Q6FRN1; -.
DR   STRING; 5478.XP_447113.1; -.
DR   PRIDE; Q6FRN1; -.
DR   EnsemblFungi; CAG60046; CAG60046; CAGL0H07271g.
DR   GeneID; 2888465; -.
DR   KEGG; cgr:CAGL0H07271g; -.
DR   CGD; CAL0130307; CAGL0H07271g.
DR   VEuPathDB; FungiDB:CAGL0H07271g; -.
DR   eggNOG; ENOG502S05I; Eukaryota.
DR   HOGENOM; CLU_046294_0_0_1; -.
DR   InParanoid; Q6FRN1; -.
DR   OMA; NDYLRHK; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0035299; F:inositol pentakisphosphate 2-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032958; P:inositol phosphate biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IEA:EnsemblFungi.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR009286; Ins_P5_2-kin.
DR   PANTHER; PTHR14456; PTHR14456; 2.
DR   Pfam; PF06090; Ins_P5_2-kin; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   Transferase.
FT   CHAIN           1..278
FT                   /note="Inositol-pentakisphosphate 2-kinase"
FT                   /id="PRO_0000110523"
FT   MOTIF           124..128
FT                   /note="EXKPK motif"
SQ   SEQUENCE   278 AA;  32200 MW;  0863FB5F08A69D29 CRC64;
     MLVAEGGANI LLELDHRGVL YRCNVRDKSL KVNNEYTYKN YRYINQVVRP LLGDCIPEME
     LVDIPYDRIS GIIGDFVGDP DSDHVSALTI KNLRPTNVYG EKIRYDDHFT KVYHDDTMEH
     ILVEIKPKWL HHAKFCRNCT HNNLKNRKIP YCYALMVVDP SHVSDMLLHT GIAFPRKFLI
     KFVDYFSKSD NILAKLHDIQ KNLDSNVSMN DIKSIDDVSD AFLLNMTLKD VSCFIEWTRE
     PDSLEVNVVD VDMKLVSKLD HWVNTHIQLS NSSNLVHH