ID   IPK1_DEBHA              Reviewed;         377 AA.
AC   Q6BHL8;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Inositol-pentakisphosphate 2-kinase;
DE            EC=2.7.1.158;
DE   AltName: Full=Inositol-1,3,4,5,6-pentakisphosphate 2-kinase;
DE   AltName: Full=Ins(1,3,4,5,6)P5 2-kinase;
DE            Short=InsP5 2-kinase;
GN   Name=IPK1; OrderedLocusNames=DEHA2G17600g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Has kinase activity and phosphorylates inositol-1,3,4,5,6-
CC       pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-
CC       hexakisphosphate (InsP6), also known as phytate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-
CC         inositol hexakisphosphate + ADP + H(+); Xref=Rhea:RHEA:20313,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733,
CC         ChEBI:CHEBI:58130, ChEBI:CHEBI:456216; EC=2.7.1.158;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The EXKPK motif is conserved in inositol-pentakisphosphate 2-
CC       kinases of both family 1 and 2.
CC   -!- SIMILARITY: Belongs to the IPK1 type 1 family. {ECO:0000305}.
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DR   EMBL; CR382139; CAG90809.2; -; Genomic_DNA.
DR   RefSeq; XP_462303.2; XM_462303.1.
DR   AlphaFoldDB; Q6BHL8; -.
DR   STRING; 4959.XP_462303.2; -.
DR   EnsemblFungi; CAG90809; CAG90809; DEHA2G17600g.
DR   GeneID; 2905241; -.
DR   KEGG; dha:DEHA2G17600g; -.
DR   VEuPathDB; FungiDB:DEHA2G17600g; -.
DR   eggNOG; ENOG502S7VH; Eukaryota.
DR   HOGENOM; CLU_046294_1_0_1; -.
DR   InParanoid; Q6BHL8; -.
DR   OMA; NDYLRHK; -.
DR   OrthoDB; 1195478at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0035299; F:inositol pentakisphosphate 2-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.200.110; -; 1.
DR   InterPro; IPR009286; Ins_P5_2-kin.
DR   InterPro; IPR043001; IP5_2-K_N_lobe.
DR   PANTHER; PTHR14456; PTHR14456; 1.
DR   Pfam; PF06090; Ins_P5_2-kin; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   Transferase.
FT   CHAIN           1..377
FT                   /note="Inositol-pentakisphosphate 2-kinase"
FT                   /id="PRO_0000110524"
FT   MOTIF           169..173
FT                   /note="EXKPK motif"
SQ   SEQUENCE   377 AA;  44424 MW;  59C8BA4FA24CE57F CRC64;
     MEIYKITTPG EWTYFAKGNA NILFKYTGSN DYLRHKLLRV RLLKEDEQYI STCELYDFIE
     LKCKPLFPHQ IIDIQLVVLT TDFVNQLNNE GNKLMVKERY GLLLPNILDG DYCKQFLSRN
     CQLYIGTDTT VQEAGVNRNT VPEKLQGQEQ KKLQKQEQFN NDIDSVIFEI KPKWLYDNIS
     SNYCRTCSLN QLRGFQRHFC PLDLLYEETI DQGLDDILSL IPQDLLIEIS ETNKIPVKQL
     FRIFLNNPNN VFQKLKEYQR INNKNDLIKN ITSIYDVSQN LSLVMTLRDV GLFIKFEKYN
     KYNNIHNSHN NINNLINIEG YGKFLLTCNI YDLDLKSKLK YKHWLDTEEK LQSIYNSSNP
     DWRHCVKVHD NTNNLGT