IPK2_ORYSI
ID IPK2_ORYSI Reviewed; 295 AA.
AC A2X5H5;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Inositol polyphosphate multikinase IPK2 {ECO:0000305};
DE Short=OsIPK2 {ECO:0000305};
DE EC=2.7.1.140 {ECO:0000305};
DE EC=2.7.1.151 {ECO:0000305};
DE AltName: Full=Inositol polyphosphate 6-/3-/5-kinase;
GN Name=IPK2 {ECO:0000305}; ORFNames=OsI_07455 {ECO:0000312|EMBL:EAY86085.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. 93-11;
RA Chen X.-F., Zhou T., Meng Z., Yang Z.-N., Xia H.-J.;
RT "Isolation and identification of inositol polyphosphate kinase gene from
RT Oryza sativa.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Inositol phosphate kinase with a broad substrate specificity.
CC Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), inositol
CC 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), inositol 1,3,4,5-
CC tetrakisphosphate (Ins(1,3,4,5)P4), inositol 1,3,4,6-tetrakisphosphate
CC (Ins(1,3,4,6)P4) and inositol 1,2,3,4,6-pentakisphosphate
CC (Ins(1,2,3,4,6)P5) but not inositol 1,4-bisphosphate (Ins(1,4)P2),
CC inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), inositol 1,2,6-
CC trisphosphate (Ins(1,2,6)P3), inositol 3,4,5,6-tetrakisphosphate
CC (Ins(3,4,5,6)P4), inositol 1,3,4,5,6-pentakisphosphate
CC (Ins(1,3,4,5,6)P5), inositol 1,2,4,5,6-pentakisphosphate
CC (Ins(1,2,4,5,6)P5) or inositol hexakisphosphate (InsP6). Regulates
CC pollen and root development probably through the regulation of InsP3-
CC mediated calcium accumulation. {ECO:0000250|UniProtKB:Q9LY23}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol
CC 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+); Xref=Rhea:RHEA:32359,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733,
CC ChEBI:CHEBI:203600, ChEBI:CHEBI:456216; EC=2.7.1.151;
CC Evidence={ECO:0000250|UniProtKB:Q9LY23};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-
CC inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+);
CC Xref=Rhea:RHEA:12717, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57660, ChEBI:CHEBI:57733, ChEBI:CHEBI:456216;
CC EC=2.7.1.140; Evidence={ECO:0000250|UniProtKB:Q9LY23};
CC -!- SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
CC {ECO:0000305}.
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DR EMBL; AY627300; AAV64028.2; -; mRNA.
DR EMBL; CM000127; EAY86085.1; -; Genomic_DNA.
DR AlphaFoldDB; A2X5H5; -.
DR SMR; A2X5H5; -.
DR STRING; 39946.A2X5H5; -.
DR EnsemblPlants; BGIOSGA008331-TA; BGIOSGA008331-PA; BGIOSGA008331.
DR Gramene; BGIOSGA008331-TA; BGIOSGA008331-PA; BGIOSGA008331.
DR HOGENOM; CLU_042569_1_2_1; -.
DR OMA; KPECGER; -.
DR Proteomes; UP000007015; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0047326; F:inositol tetrakisphosphate 5-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000823; F:inositol-1,4,5-trisphosphate 6-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0102732; F:myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0032958; P:inositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.470.160; -; 1.
DR InterPro; IPR005522; IPK.
DR InterPro; IPR038286; IPK_sf.
DR PANTHER; PTHR12400; PTHR12400; 1.
DR Pfam; PF03770; IPK; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1..295
FT /note="Inositol polyphosphate multikinase IPK2"
FT /id="PRO_0000431884"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 295 AA; 31029 MW; 97932BDB26C65FCC CRC64;
MASDLRPPEH QVAGHRASAD KLGPLVDGEG LFYKPLQAGE RGEHEAAFYA AFTAHPAVPP
RVRGAFFPRF HGTRFLPAPA SPGGAPYPHI VLDDLLAGLP SPCVADVKIG ACTWPPRSPD
PYVAKCLAKD RETTSALLGF RVSGVRVVDA RGGAVWRPDR SELKGIDAAG VRRVLRRYVS
TGGGDGLDCA LAAAVYGGEG GVLAQLRELK AWFEEQTLYH FYSASILFGY DANAAAAAAP
GGGSGGVRVK LVDFAHVDDG DGVIDHNFLG GLCSLIKFIG DIVAEVTEKA SSDHS
