ID   IPKA_CHICK              Reviewed;          76 AA.
AC   Q90641; Q9PUU7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=cAMP-dependent protein kinase inhibitor alpha;
DE            Short=PKI-alpha;
DE   AltName: Full=cAMP-dependent protein kinase inhibitor, kidney isoform;
GN   Name=PKIA;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Kidney;
RX   PubMed=7607559; DOI=10.1016/0378-1119(95)00118-p;
RA   Marchetto G.S., Henry H.L.;
RT   "Cloning and sequencing of the cDNA encoding the avian kidney cAMP-
RT   dependent protein kinase inhibitor protein.";
RL   Gene 158:303-304(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50.
RC   STRAIN=White leghorn; TISSUE=Kidney;
RX   PubMed=10524218; DOI=10.1016/s0167-4781(99)00101-3;
RA   Rowland-Goldsmith M.A., Holmquist B., Henry H.L.;
RT   "Genomic cloning, structure, and regulatory elements of the 1 alpha,
RT   25(OH)2D3 down-regulated gene for cyclic AMP-dependent protein kinase
RT   inhibitor.";
RL   Biochim. Biophys. Acta 1446:414-418(1999).
CC   -!- FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent
CC       protein kinase activity, this protein interacts with the catalytic
CC       subunit of the enzyme after the cAMP-induced dissociation of its
CC       regulatory chains. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PKI family. {ECO:0000305}.
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DR   EMBL; U19496; AAA86697.1; -; mRNA.
DR   EMBL; AF139056; AAD30289.1; -; Genomic_DNA.
DR   PIR; JC4128; JC4128.
DR   RefSeq; NP_990705.1; NM_205374.1.
DR   AlphaFoldDB; Q90641; -.
DR   STRING; 9031.ENSGALP00000025326; -.
DR   PaxDb; Q90641; -.
DR   Ensembl; ENSGALT00000101180; ENSGALP00000073758; ENSGALG00000053281.
DR   GeneID; 396333; -.
DR   KEGG; gga:396333; -.
DR   CTD; 5569; -.
DR   VEuPathDB; HostDB:geneid_396333; -.
DR   eggNOG; ENOG502S6JP; Eukaryota.
DR   GeneTree; ENSGT00530000064276; -.
DR   HOGENOM; CLU_163471_2_0_1; -.
DR   InParanoid; Q90641; -.
DR   OrthoDB; 1648219at2759; -.
DR   PhylomeDB; Q90641; -.
DR   TreeFam; TF330809; -.
DR   PRO; PR:Q90641; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000053281; Expressed in muscle tissue and 13 other tissues.
DR   ExpressionAtlas; Q90641; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IBA:GO_Central.
DR   GO; GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IBA:GO_Central.
DR   InterPro; IPR004171; cAMP_dep_PKI.
DR   PANTHER; PTHR15416; PTHR15416; 1.
DR   Pfam; PF02827; PKI; 1.
DR   PIRSF; PIRSF001667; PKI; 1.
PE   3: Inferred from homology;
KW   Protein kinase inhibitor; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..76
FT                   /note="cAMP-dependent protein kinase inhibitor alpha"
FT                   /id="PRO_0000154537"
FT   REGION          49..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            16
FT                   /note="Important for inhibition"
FT                   /evidence="ECO:0000250"
FT   SITE            19
FT                   /note="Important for inhibition"
FT                   /evidence="ECO:0000250"
FT   SITE            20
FT                   /note="Important for inhibition"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="Blocked amino end (Thr)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   76 AA;  8008 MW;  50507DB523DB8353 CRC64;
     MTDVESTYAD FIASGRTGRR NALHDILVSS PGGNSSELAL KLSELDINKA EGEGDAQRNP
     SEQTGEAQGE AAKQES