IPKG_HUMAN
ID IPKG_HUMAN Reviewed; 76 AA.
AC Q9Y2B9;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=cAMP-dependent protein kinase inhibitor gamma;
DE Short=PKI-gamma;
GN Name=PKIG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Saito T., Miyajima N.;
RT "Protein kinase inhibitor gamma mRNA, complete cds.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Parathyroid;
RX PubMed=9218452; DOI=10.1074/jbc.272.29.18169;
RA Collins S.P., Uhler M.D.;
RT "Characterization of PKI-gamma, a novel isoform of the protein kinase
RT inhibitor of cAMP-dependent protein kinase.";
RL J. Biol. Chem. 272:18169-18178(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10880337; DOI=10.1042/0264-6021:3490403;
RA Zheng L., Yu L., Tu Q., Zhang M., He H., Chen W., Gao J., Yu J., Wu Q.,
RA Zhao S.;
RT "Cloning and mapping of human PKIB and PKIG, and comparison of tissue
RT expression patterns of three members of the protein kinase inhibitor
RT family, including PKIA.";
RL Biochem. J. 349:403-407(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent
CC protein kinase activity, this protein interacts with the catalytic
CC subunit of the enzyme after the cAMP-induced dissociation of its
CC regulatory chains. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9Y2B9; P63167: DYNLL1; NbExp=5; IntAct=EBI-1052231, EBI-349105;
CC Q9Y2B9; Q96FJ2: DYNLL2; NbExp=3; IntAct=EBI-1052231, EBI-742371;
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Belongs to the PKI family. {ECO:0000305}.
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DR EMBL; AB019517; BAA77336.1; -; mRNA.
DR EMBL; AF182032; AAD55445.1; -; mRNA.
DR EMBL; Z97053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS13334.1; -.
DR RefSeq; NP_001268373.1; NM_001281444.1.
DR RefSeq; NP_001268374.1; NM_001281445.1.
DR RefSeq; NP_008997.1; NM_007066.4.
DR RefSeq; NP_861520.1; NM_181804.2.
DR RefSeq; NP_861521.1; NM_181805.2.
DR RefSeq; XP_016883103.1; XM_017027614.1.
DR RefSeq; XP_016883104.1; XM_017027615.1.
DR RefSeq; XP_016883105.1; XM_017027616.1.
DR AlphaFoldDB; Q9Y2B9; -.
DR BioGRID; 116314; 12.
DR IntAct; Q9Y2B9; 6.
DR STRING; 9606.ENSP00000361980; -.
DR iPTMnet; Q9Y2B9; -.
DR PhosphoSitePlus; Q9Y2B9; -.
DR BioMuta; PKIG; -.
DR EPD; Q9Y2B9; -.
DR jPOST; Q9Y2B9; -.
DR MassIVE; Q9Y2B9; -.
DR MaxQB; Q9Y2B9; -.
DR PaxDb; Q9Y2B9; -.
DR PeptideAtlas; Q9Y2B9; -.
DR PRIDE; Q9Y2B9; -.
DR ProteomicsDB; 85722; -.
DR Antibodypedia; 27423; 72 antibodies from 17 providers.
DR DNASU; 11142; -.
DR Ensembl; ENST00000349959.3; ENSP00000338067.3; ENSG00000168734.14.
DR Ensembl; ENST00000372886.6; ENSP00000361977.1; ENSG00000168734.14.
DR Ensembl; ENST00000372889.5; ENSP00000361980.1; ENSG00000168734.14.
DR Ensembl; ENST00000372891.7; ENSP00000361981.3; ENSG00000168734.14.
DR Ensembl; ENST00000372892.7; ENSP00000361983.3; ENSG00000168734.14.
DR Ensembl; ENST00000372894.7; ENSP00000361985.3; ENSG00000168734.14.
DR GeneID; 11142; -.
DR KEGG; hsa:11142; -.
DR MANE-Select; ENST00000372886.6; ENSP00000361977.1; NM_001281445.2; NP_001268374.1.
DR UCSC; uc002xmg.5; human.
DR CTD; 11142; -.
DR DisGeNET; 11142; -.
DR GeneCards; PKIG; -.
DR HGNC; HGNC:9019; PKIG.
DR HPA; ENSG00000168734; Low tissue specificity.
DR MIM; 604932; gene.
DR neXtProt; NX_Q9Y2B9; -.
DR OpenTargets; ENSG00000168734; -.
DR PharmGKB; PA33351; -.
DR VEuPathDB; HostDB:ENSG00000168734; -.
DR eggNOG; ENOG502SBS3; Eukaryota.
DR GeneTree; ENSGT00390000002707; -.
DR HOGENOM; CLU_163471_2_0_1; -.
DR InParanoid; Q9Y2B9; -.
DR OMA; DATGMME; -.
DR OrthoDB; 1628240at2759; -.
DR PhylomeDB; Q9Y2B9; -.
DR TreeFam; TF330809; -.
DR PathwayCommons; Q9Y2B9; -.
DR SignaLink; Q9Y2B9; -.
DR BioGRID-ORCS; 11142; 17 hits in 1076 CRISPR screens.
DR ChiTaRS; PKIG; human.
DR GeneWiki; PKIG; -.
DR GenomeRNAi; 11142; -.
DR Pharos; Q9Y2B9; Tbio.
DR PRO; PR:Q9Y2B9; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9Y2B9; protein.
DR Bgee; ENSG00000168734; Expressed in right coronary artery and 201 other tissues.
DR ExpressionAtlas; Q9Y2B9; baseline and differential.
DR Genevisible; Q9Y2B9; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IBA:GO_Central.
DR GO; GO:0042308; P:negative regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR InterPro; IPR004171; cAMP_dep_PKI.
DR PANTHER; PTHR15416; PTHR15416; 1.
DR Pfam; PF02827; PKI; 1.
DR PIRSF; PIRSF001667; PKI; 1.
PE 1: Evidence at protein level;
KW Protein kinase inhibitor; Reference proteome.
FT CHAIN 1..76
FT /note="cAMP-dependent protein kinase inhibitor gamma"
FT /id="PRO_0000154542"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 76 AA; 7910 MW; F01B4C73ED2CC6EE CRC64;
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA EGQVEGSAPD
KEAGNQPQSS DGTTSS
