IPKG_MOUSE
ID IPKG_MOUSE Reviewed; 76 AA.
AC O70139;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=cAMP-dependent protein kinase inhibitor gamma;
DE Short=PKI-gamma;
GN Name=Pkig;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=9218452; DOI=10.1074/jbc.272.29.18169;
RA Collins S.P., Uhler M.D.;
RT "Characterization of PKI-gamma, a novel isoform of the protein kinase
RT inhibitor of cAMP-dependent protein kinase.";
RL J. Biol. Chem. 272:18169-18178(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
CC -!- FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent
CC protein kinase activity, this protein interacts with the catalytic
CC subunit of the enzyme after the cAMP-induced dissociation of its
CC regulatory chains. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PKI family. {ECO:0000305}.
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DR EMBL; U97170; AAC09065.1; -; mRNA.
DR EMBL; BC026550; AAH26550.1; -; mRNA.
DR CCDS; CCDS17014.1; -.
DR RefSeq; NP_001034479.1; NM_001039390.2.
DR RefSeq; NP_001034480.1; NM_001039391.2.
DR RefSeq; NP_001157525.1; NM_001164053.1.
DR RefSeq; NP_001157527.1; NM_001164055.1.
DR RefSeq; NP_035236.1; NM_011106.2.
DR RefSeq; XP_006498989.1; XM_006498926.3.
DR RefSeq; XP_006498990.1; XM_006498927.1.
DR AlphaFoldDB; O70139; -.
DR BioGRID; 202209; 1.
DR STRING; 10090.ENSMUSP00000105027; -.
DR PhosphoSitePlus; O70139; -.
DR PaxDb; O70139; -.
DR PRIDE; O70139; -.
DR ProteomicsDB; 269497; -.
DR Antibodypedia; 27423; 72 antibodies from 17 providers.
DR DNASU; 18769; -.
DR Ensembl; ENSMUST00000064703; ENSMUSP00000068344; ENSMUSG00000035268.
DR Ensembl; ENSMUST00000099105; ENSMUSP00000096704; ENSMUSG00000035268.
DR Ensembl; ENSMUST00000109400; ENSMUSP00000105027; ENSMUSG00000035268.
DR Ensembl; ENSMUST00000126182; ENSMUSP00000120145; ENSMUSG00000035268.
DR Ensembl; ENSMUST00000164399; ENSMUSP00000126223; ENSMUSG00000035268.
DR GeneID; 18769; -.
DR KEGG; mmu:18769; -.
DR UCSC; uc008nth.2; mouse.
DR CTD; 11142; -.
DR MGI; MGI:1343086; Pkig.
DR VEuPathDB; HostDB:ENSMUSG00000035268; -.
DR eggNOG; ENOG502SBS3; Eukaryota.
DR GeneTree; ENSGT00390000002707; -.
DR InParanoid; O70139; -.
DR OMA; DATGMME; -.
DR OrthoDB; 1628240at2759; -.
DR PhylomeDB; O70139; -.
DR TreeFam; TF330809; -.
DR BioGRID-ORCS; 18769; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Pkig; mouse.
DR PRO; PR:O70139; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; O70139; protein.
DR Bgee; ENSMUSG00000035268; Expressed in otic placode and 259 other tissues.
DR ExpressionAtlas; O70139; baseline and differential.
DR Genevisible; O70139; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IDA:MGI.
DR GO; GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IBA:GO_Central.
DR GO; GO:0042308; P:negative regulation of protein import into nucleus; IDA:MGI.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IDA:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0007165; P:signal transduction; ISO:MGI.
DR InterPro; IPR004171; cAMP_dep_PKI.
DR PANTHER; PTHR15416; PTHR15416; 1.
DR Pfam; PF02827; PKI; 1.
DR PIRSF; PIRSF001667; PKI; 1.
PE 1: Evidence at protein level;
KW Protein kinase inhibitor; Reference proteome.
FT CHAIN 1..76
FT /note="cAMP-dependent protein kinase inhibitor gamma"
FT /id="PRO_0000154543"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 76 AA; 7943 MW; 965F577D80C8DE59 CRC64;
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA EGQAEGSTPD
KEASSQPESS DANTSS
