IPKG_PIG
ID IPKG_PIG Reviewed; 76 AA.
AC Q7YQJ4;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=cAMP-dependent protein kinase inhibitor gamma;
DE Short=PKI-gamma;
GN Name=PKIG;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhou G., Li W., Yu L., Wang J., Zhao S.;
RT "Cloning of Sus scrofa protein kinase inhibitor gamma (Pkig), mRNA.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent
CC protein kinase activity, this protein interacts with the catalytic
CC subunit of the enzyme after the cAMP-induced dissociation of its
CC regulatory chains. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PKI family. {ECO:0000305}.
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DR EMBL; AY339895; AAQ17070.1; -; mRNA.
DR RefSeq; NP_999536.1; NM_214371.1.
DR RefSeq; XP_005673006.1; XM_005672949.2.
DR RefSeq; XP_005673007.1; XM_005672950.2.
DR RefSeq; XP_013840843.1; XM_013985389.1.
DR AlphaFoldDB; Q7YQJ4; -.
DR STRING; 9823.ENSSSCP00000026610; -.
DR PaxDb; Q7YQJ4; -.
DR Ensembl; ENSSSCT00000026128; ENSSSCP00000026610; ENSSSCG00000022998.
DR Ensembl; ENSSSCT00015103350; ENSSSCP00015043046; ENSSSCG00015076603.
DR Ensembl; ENSSSCT00025074825; ENSSSCP00025032439; ENSSSCG00025054711.
DR Ensembl; ENSSSCT00030020122; ENSSSCP00030008967; ENSSSCG00030014616.
DR Ensembl; ENSSSCT00035106857; ENSSSCP00035046075; ENSSSCG00035078342.
DR Ensembl; ENSSSCT00040075875; ENSSSCP00040032588; ENSSSCG00040055998.
DR Ensembl; ENSSSCT00045067775; ENSSSCP00045048166; ENSSSCG00045038988.
DR Ensembl; ENSSSCT00050003147; ENSSSCP00050001046; ENSSSCG00050002503.
DR Ensembl; ENSSSCT00055017000; ENSSSCP00055013421; ENSSSCG00055008714.
DR Ensembl; ENSSSCT00060007993; ENSSSCP00060002883; ENSSSCG00060006305.
DR Ensembl; ENSSSCT00065100947; ENSSSCP00065044423; ENSSSCG00065073339.
DR Ensembl; ENSSSCT00070023867; ENSSSCP00070019733; ENSSSCG00070012212.
DR Ensembl; ENSSSCT00070023871; ENSSSCP00070019738; ENSSSCG00070012212.
DR GeneID; 397661; -.
DR KEGG; ssc:397661; -.
DR CTD; 11142; -.
DR VGNC; VGNC:96486; PKIG.
DR eggNOG; ENOG502SBS3; Eukaryota.
DR GeneTree; ENSGT00390000002707; -.
DR HOGENOM; CLU_163471_2_0_1; -.
DR InParanoid; Q7YQJ4; -.
DR OMA; DATGMME; -.
DR OrthoDB; 1628240at2759; -.
DR TreeFam; TF330809; -.
DR Proteomes; UP000008227; Chromosome 17.
DR Proteomes; UP000314985; Chromosome 17.
DR Bgee; ENSSSCG00000022998; Expressed in ovary and 45 other tissues.
DR Genevisible; Q7YQJ4; SS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IBA:GO_Central.
DR GO; GO:0042308; P:negative regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR InterPro; IPR004171; cAMP_dep_PKI.
DR PANTHER; PTHR15416; PTHR15416; 1.
DR Pfam; PF02827; PKI; 1.
DR PIRSF; PIRSF001667; PKI; 1.
PE 3: Inferred from homology;
KW Protein kinase inhibitor; Reference proteome.
FT CHAIN 1..76
FT /note="cAMP-dependent protein kinase inhibitor gamma"
FT /id="PRO_0000154544"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 76 AA; 7912 MW; 871B576896A8DE59 CRC64;
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA EGQAEGGTPD
KEASNQPQSS DGTTSS
