APOF_MOUSE
ID APOF_MOUSE Reviewed; 315 AA.
AC Q91V80;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Apolipoprotein F;
DE Short=Apo-F;
DE AltName: Full=Leukemia virus-inactivating factor;
DE Short=LVIF;
DE Flags: Precursor;
GN Name=Apof; Synonyms=Lvif;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=C58/J, CAST/EiJ, and NFS;
RX PubMed=11836406; DOI=10.1128/jvi.76.5.2279-2286.2002;
RA Wu T., Lee C.G., Buckler-White A., Kozak C.A.;
RT "Genetic control of a mouse serum lipoprotein factor that inactivates
RT murine leukemia viruses: evaluation of apolipoprotein F as a candidate.";
RL J. Virol. 76:2279-2286(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Minor apolipoprotein that associates with LDL. Inhibits
CC cholesteryl ester transfer protein (CETP) activity and appears to be an
CC important regulator of cholesterol transport. Also associates to a
CC lesser degree with VLDL, Apo-AI and Apo-AII.
CC {ECO:0000250|UniProtKB:Q13790}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q13790}.
CC -!- TISSUE SPECIFICITY: Liver. {ECO:0000269|PubMed:11836406}.
CC -!- SIMILARITY: Belongs to the apolipoprotein F family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH10815.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH22795.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH24769.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH25827.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL06339.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL06340.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL06341.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF411830; AAL06339.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF411831; AAL06340.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF411832; AAL06341.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC010815; AAH10815.1; ALT_INIT; mRNA.
DR EMBL; BC022795; AAH22795.1; ALT_INIT; mRNA.
DR EMBL; BC024769; AAH24769.1; ALT_INIT; mRNA.
DR EMBL; BC025827; AAH25827.1; ALT_INIT; mRNA.
DR CCDS; CCDS24268.2; -.
DR RefSeq; NP_598758.1; NM_133997.2.
DR AlphaFoldDB; Q91V80; -.
DR STRING; 10090.ENSMUSP00000050300; -.
DR iPTMnet; Q91V80; -.
DR PhosphoSitePlus; Q91V80; -.
DR CPTAC; non-CPTAC-3959; -.
DR MaxQB; Q91V80; -.
DR PaxDb; Q91V80; -.
DR PeptideAtlas; Q91V80; -.
DR PRIDE; Q91V80; -.
DR ProteomicsDB; 281900; -.
DR Antibodypedia; 28188; 300 antibodies from 34 providers.
DR DNASU; 103161; -.
DR Ensembl; ENSMUST00000050901; ENSMUSP00000050300; ENSMUSG00000047631.
DR GeneID; 103161; -.
DR KEGG; mmu:103161; -.
DR UCSC; uc007hlz.1; mouse.
DR CTD; 319; -.
DR MGI; MGI:104539; Apof.
DR VEuPathDB; HostDB:ENSMUSG00000047631; -.
DR eggNOG; ENOG502QUQ0; Eukaryota.
DR GeneTree; ENSGT00500000045104; -.
DR InParanoid; Q91V80; -.
DR OMA; PGFTHMA; -.
DR OrthoDB; 1568974at2759; -.
DR PhylomeDB; Q91V80; -.
DR TreeFam; TF338778; -.
DR BioGRID-ORCS; 103161; 3 hits in 76 CRISPR screens.
DR ChiTaRS; Apof; mouse.
DR PRO; PR:Q91V80; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q91V80; protein.
DR Bgee; ENSMUSG00000047631; Expressed in left lobe of liver and 39 other tissues.
DR ExpressionAtlas; Q91V80; baseline and differential.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0033344; P:cholesterol efflux; IGI:MGI.
DR GO; GO:0008203; P:cholesterol metabolic process; IMP:MGI.
DR GO; GO:0006641; P:triglyceride metabolic process; IMP:MGI.
DR InterPro; IPR026114; APOF.
DR PANTHER; PTHR15011; PTHR15011; 1.
DR Pfam; PF15148; Apolipo_F; 1.
PE 2: Evidence at transcript level;
KW Cholesterol metabolism; Cleavage on pair of basic residues; HDL; LDL;
KW Lipid metabolism; Lipid transport; Reference proteome; Secreted; Signal;
KW Steroid metabolism; Sterol metabolism; Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..154
FT /evidence="ECO:0000255"
FT /id="PRO_0000002053"
FT CHAIN 155..315
FT /note="Apolipoprotein F"
FT /id="PRO_0000002054"
SQ SEQUENCE 315 AA; 34359 MW; FB669F792B3E90E7 CRC64;
MHSLRLILMS IQLLCYLLLC PVDATSHGEA TSVSTVLPPS KLGYQMQTSD KPLSCQMLLP
KSLPGFTYMP PVSKFLVGLA LRNALEAAGC QAEVWALQLQ LYRLGGVEAT QALIHHLQEL
QKSGHTDREV SVDALSSALQ LLAWEQPGPK RAKRSISNTD CDNDQEQSVH NVVDLLPAVG
TYYNLGTALY YAIKNCSDKA KERGRDGAID LGYDLLMAMV GASGGPAGAV ITAALKPAMK
AGVQRLIQYY YDEKEVTTPQ PEVTTHQPET GKDATTDIGV VEEIAMSNFV SEVESTTSNW
EWPLLKNYGV LAYKR
