ID   APOF_RAT                Reviewed;         308 AA.
AC   Q5M889; Q7TP25;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Apolipoprotein F;
DE            Short=Apo-F;
DE   AltName: Full=Liver regeneration-related protein LRRG151;
DE   Flags: Precursor;
GN   Name=Apof; ORFNames=Ba1-666;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 69-308.
RC   TISSUE=Liver;
RA   Xu C.S., Yuan J.Y., Li W.Q., Han H.P., Yang K.J., Chang C.F., Zhao L.F.,
RA   Li Y.C., Zhang H.Y., Rahman S., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Minor apolipoprotein that associates with LDL. Inhibits
CC       cholesteryl ester transfer protein (CETP) activity and appears to be an
CC       important regulator of cholesterol transport. Also associates to a
CC       lesser degree with VLDL, Apo-AI and Apo-AII.
CC       {ECO:0000250|UniProtKB:Q13790}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q13790}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein F family. {ECO:0000305}.
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DR   EMBL; BC088170; AAH88170.1; -; mRNA.
DR   EMBL; AY325229; AAP92630.1; -; mRNA.
DR   RefSeq; NP_001019522.1; NM_001024351.1.
DR   AlphaFoldDB; Q5M889; -.
DR   STRING; 10116.ENSRNOP00000049259; -.
DR   PaxDb; Q5M889; -.
DR   PRIDE; Q5M889; -.
DR   GeneID; 500761; -.
DR   KEGG; rno:500761; -.
DR   UCSC; RGD:1560713; rat.
DR   CTD; 319; -.
DR   RGD; 1560713; Apof.
DR   eggNOG; ENOG502QUQ0; Eukaryota.
DR   HOGENOM; CLU_078958_0_0_1; -.
DR   InParanoid; Q5M889; -.
DR   OMA; PGFTHMA; -.
DR   OrthoDB; 1568974at2759; -.
DR   PhylomeDB; Q5M889; -.
DR   TreeFam; TF338778; -.
DR   PRO; PR:Q5M889; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000033619; Expressed in liver and 3 other tissues.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0033344; P:cholesterol efflux; ISO:RGD.
DR   GO; GO:0008203; P:cholesterol metabolic process; ISO:RGD.
DR   GO; GO:0006641; P:triglyceride metabolic process; ISO:RGD.
DR   InterPro; IPR026114; APOF.
DR   PANTHER; PTHR15011; PTHR15011; 1.
DR   Pfam; PF15148; Apolipo_F; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; Cleavage on pair of basic residues; HDL; LDL;
KW   Lipid metabolism; Lipid transport; Reference proteome; Secreted; Signal;
KW   Steroid metabolism; Sterol metabolism; Transport.
FT   SIGNAL          1..?
FT                   /evidence="ECO:0000255"
FT   PROPEP          ?..154
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000002055"
FT   CHAIN           155..308
FT                   /note="Apolipoprotein F"
FT                   /id="PRO_0000002056"
SQ   SEQUENCE   308 AA;  33842 MW;  490B55D6A3692F46 CRC64;
     MGAQLLTCTV SDSIRHQFSC FATSCCVLWV PKGVSTMLPP SQLGSQPPTS DPLSCQALLP
     RSLPGFTHMP PLSKFLVGLA LRNALEEAGC WADVWALQLQ LYRFGGVEAT QALIRHLQEL
     QKGGRADWKV SVNALSSALQ LLAWEQAGPK RVKRSLSNMG CENEQEQRVH NVVELLPAVG
     TYYNLGTALY YAIKNCTDKA KERGRDGAID LGYDLLMTMV GMSGGPTGAV ITAALKPALK
     AGVQRLIRYY HDEEGVTTSQ PETRKDAPTY RDDVEETTMS NLVSEVESTT SNWGRPLLKN
     YVFLAYKR