IPO13_CHICK
ID IPO13_CHICK Reviewed; 958 AA.
AC Q5ZIC8;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Importin-13;
DE Short=Imp13;
GN Name=IPO13; ORFNames=RCJMB04_27p9;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Functions in nuclear protein import as nuclear transport
CC receptor. Serves as receptor for nuclear localization signals (NLS) in
CC cargo substrates. Is thought to mediate docking of the
CC importin/substrate complex to the nuclear pore complex (NPC) through
CC binding to nucleoporin and the complex is subsequently translocated
CC through the pore by an energy requiring, Ran-dependent mechanism. At
CC the nucleoplasmic side of the NPC, Ran binds to the importin, the
CC importin/substrate complex dissociates and importin is re-exported from
CC the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The
CC directionality of nuclear import is thought to be conferred by an
CC asymmetric distribution of the GTP- and GDP-bound forms of Ran between
CC the cytoplasm and nucleus (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ720856; CAG32515.1; -; mRNA.
DR RefSeq; NP_001006537.1; NM_001006537.1.
DR AlphaFoldDB; Q5ZIC8; -.
DR SMR; Q5ZIC8; -.
DR STRING; 9031.ENSGALP00000016380; -.
DR PaxDb; Q5ZIC8; -.
DR GeneID; 424573; -.
DR KEGG; gga:424573; -.
DR CTD; 9670; -.
DR VEuPathDB; HostDB:geneid_424573; -.
DR eggNOG; KOG2022; Eukaryota.
DR InParanoid; Q5ZIC8; -.
DR OrthoDB; 1032285at2759; -.
DR PhylomeDB; Q5ZIC8; -.
DR PRO; PR:Q5ZIC8; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR040709; Importin_rep_1.
DR InterPro; IPR040944; Importin_rep_2.
DR InterPro; IPR040520; Importin_rep_3.
DR Pfam; PF18773; Importin_rep; 1.
DR Pfam; PF18786; Importin_rep_2; 2.
DR Pfam; PF18806; Importin_rep_3; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..958
FT /note="Importin-13"
FT /id="PRO_0000357048"
FT REPEAT 19..49
FT /note="HEAT 1"
FT DOMAIN 40..106
FT /note="Importin N-terminal"
FT REPEAT 51..83
FT /note="HEAT 2"
FT REPEAT 90..130
FT /note="HEAT 3"
FT REPEAT 137..174
FT /note="HEAT 4"
FT REPEAT 189..226
FT /note="HEAT 5"
FT REPEAT 231..263
FT /note="HEAT 6"
FT REPEAT 271..320
FT /note="HEAT 7"
FT REPEAT 325..367
FT /note="HEAT 8"
FT REPEAT 370..433
FT /note="HEAT 9"
FT REPEAT 435..471
FT /note="HEAT 10"
FT REPEAT 482..517
FT /note="HEAT 11"
FT REPEAT 519..553
FT /note="HEAT 12"
FT REPEAT 557..595
FT /note="HEAT 13"
FT REPEAT 598..643
FT /note="HEAT 14"
FT REPEAT 671..711
FT /note="HEAT 15"
FT REPEAT 715..749
FT /note="HEAT 16"
FT REPEAT 756..798
FT /note="HEAT 17"
FT REPEAT 810..840
FT /note="HEAT 18"
FT REPEAT 855..888
FT /note="HEAT 19"
FT REPEAT 892..926
FT /note="HEAT 20"
SQ SEQUENCE 958 AA; 107776 MW; 11905A741DDBF0B7 CRC64;
MERRAEAPPP PQGLDFTVEN VEKALHQLYY DPNIENKNLA QKWLMQAQVS PQAWHFSWLL
LNMDKVPEIQ YSAPAPCTSR SPATGTTSLP DQYESLKSQL FTHITRFAGG SKIVLTRLCV
ALASLALSMM PEAWPCAVAD MVRMFQAEDS NVDGRARCLA LLELLTVLPE EFQTSRLPQY
RKGQVRSVLA QECGSVFPLL EQLLQQQDSP GFIKQKVLKC FSSWVQLEIP LMDCENLIQA
AFTSLQDPEL FDTAVEAVVN AISQPDAQRY VNTLLKLIPP VLGLQEQLRQ AVQSGDMETS
HGICRIAVAL GENHSRALLD QVEHWQSFLA LVNMIMFCTG IPGHYPVNET TSSLTLTFWY
TLQDDILSFE PDKQAVYQQV YRPVYFQLVD VLLHKAQFPS DEEYGFWSSD EKEQFRIYRV
DISDTLMYVY EMLGAELLSS LYDKLGRLLT NTEQPSTWQH TEALLYGFQS IAETIDVNYS
DVVPGLIGLI PRISISNVQL ADTVMFTIGA LSEWLADHPV MINNVLPLVL QALGNPELSI
SSVSTLKKIC RECKYDLPPY AANIVAVSQE VLMKQIHKTS QCMWLMQALG FLLSALQVEE
ILKNLHSLIT PYIQQLEKLA DETPNPSNKL AIIHILGLLS NLFTTLDISH HDDDHESTEV
KKLPVQQGPN PVVVVLQQVF QLIQKVLSKW LNDAQVVESV CAIFEKSVKT LLDDFAPMVP
QLCEMLGQMY STIPQASAID LTRQLVHIFA HEPAHFPPIK ALFLLVTSVT LTLFQQGPRD
HPDIVDSFMQ LLAQALKRKP DLFLCSNLDV KALFHCGVLS LKFPEAPTVK ASCGFFTELL
PRCGEIAPVG QVVHENGKVL LQAVLEGVGG QASRSLMDHF AEILFALNKH CFSYLSIWIK
EAMQQDGFPS ARVSPEQKET FSQQILRERV NKRRVKEMVK EFTLLCRGLH GTEYTADY
