IPO13_PONAB
ID IPO13_PONAB Reviewed; 963 AA.
AC Q5R974;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Importin-13;
DE Short=Imp13;
GN Name=IPO13;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in nuclear protein import as nuclear transport
CC receptor. Serves as receptor for nuclear localization signals (NLS) in
CC cargo substrates. Is thought to mediate docking of the
CC importin/substrate complex to the nuclear pore complex (NPC) through
CC binding to nucleoporin and the complex is subsequently translocated
CC through the pore by an energy requiring, Ran-dependent mechanism. At
CC the nucleoplasmic side of the NPC, Ran binds to the importin, the
CC importin/substrate complex dissociates and importin is re-exported from
CC the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The
CC directionality of nuclear import is thought to be conferred by an
CC asymmetric distribution of the GTP- and GDP-bound forms of Ran between
CC the cytoplasm and nucleus (By similarity). Mediates the nuclear import
CC of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of
CC the paired homeobox family. Also mediates nuclear export of eIF-1A, and
CC the cytoplasmic release of eIF-1A is triggered by the loading of import
CC substrates onto IPO13 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
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DR EMBL; CR859518; CAH91686.1; -; mRNA.
DR RefSeq; NP_001125988.1; NM_001132516.1.
DR AlphaFoldDB; Q5R974; -.
DR SMR; Q5R974; -.
DR STRING; 9601.ENSPPYP00000011931; -.
DR GeneID; 100172927; -.
DR KEGG; pon:100172927; -.
DR CTD; 9670; -.
DR eggNOG; KOG2022; Eukaryota.
DR InParanoid; Q5R974; -.
DR OrthoDB; 1032285at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IEA:UniProt.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040709; Importin_rep_1.
DR InterPro; IPR040944; Importin_rep_2.
DR InterPro; IPR040520; Importin_rep_3.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF18773; Importin_rep; 1.
DR Pfam; PF18786; Importin_rep_2; 2.
DR Pfam; PF18806; Importin_rep_3; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..963
FT /note="Importin-13"
FT /id="PRO_0000357047"
FT REPEAT 24..54
FT /note="HEAT 1"
FT DOMAIN 45..111
FT /note="Importin N-terminal"
FT REPEAT 56..88
FT /note="HEAT 2"
FT REPEAT 95..135
FT /note="HEAT 3"
FT REPEAT 142..179
FT /note="HEAT 4"
FT REPEAT 194..231
FT /note="HEAT 5"
FT REPEAT 236..268
FT /note="HEAT 6"
FT REPEAT 276..325
FT /note="HEAT 7"
FT REPEAT 330..372
FT /note="HEAT 8"
FT REPEAT 375..438
FT /note="HEAT 9"
FT REPEAT 440..476
FT /note="HEAT 10"
FT REPEAT 487..522
FT /note="HEAT 11"
FT REPEAT 524..558
FT /note="HEAT 12"
FT REPEAT 562..600
FT /note="HEAT 13"
FT REPEAT 603..648
FT /note="HEAT 14"
FT REPEAT 676..716
FT /note="HEAT 15"
FT REPEAT 720..754
FT /note="HEAT 16"
FT REPEAT 761..803
FT /note="HEAT 17"
FT REPEAT 815..845
FT /note="HEAT 18"
FT REPEAT 860..893
FT /note="HEAT 19"
FT REPEAT 897..931
FT /note="HEAT 20"
SQ SEQUENCE 963 AA; 108040 MW; 44DE1AAB3667BB9A CRC64;
MERREEQPGA AGAGAAPALD FTVESVEKAL HQLYYDPNIE NKNLAQKWLM QAQVSPQAWH
FSWQLLQPDK VPEIQYFGAS ALPIKTSRYW SDIPTDQYES LKAQLFTQIT RFASGSKIVL
TRLCVALASL ALSMMPDAWP CAVADMVRLF QAEDSPVDGQ GRCLALLELL TVLPEEFQTS
RLPQYRKGLV RTSLAVECGA VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE
ALIQAAFAAL QDSELFDSSV EAIVNAISQP DAQRCVNTLL KLIPLVLGLQ EQLRQAVQNG
DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY PVNETTSSLT
LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK AQFPSDEEYG FWSSDEKEQF
RIYRVDISDT LMYVYEMLGA ELLSNLYDKL GRLLTSSEEP YSWQHTEALL YGFQSIAETI
DVNYSDVVPG LIGLIPRISI SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN
PEPSVSSVST LKKICRECKY DLPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA
LQVEEILKNL HSLISPYIQQ LEKLAEEIPN PSNKLAIVHI LGLLSNLFTT LDISHHEDDH
EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLNDAQ VVEAVCAIFE KSVKTLLDDF
APMVPQLCEM LGRMYSTIPQ ASALDLTRQL VHIFAHEPAH FPPIEALFLL VTSVTLTLFQ
QGPRDHPDIV DSFMQLLAQA LKRKPDLFLC ERLDVKAVFQ CAVLALKFPE APTVKASCGF
FTELLPRCGE VESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL
SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL CRGLHGTDYT
ADY
