ID   IPO13_RAT               Reviewed;         963 AA.
AC   Q9JM04;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Importin-13;
DE            Short=Imp13;
DE   AltName: Full=Late gestation lung 2 protein;
GN   Name=Ipo13; Synonyms=Imp13, Lgl2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   INDUCTION.
RC   STRAIN=Wistar; TISSUE=Lung;
RX   PubMed=10745026; DOI=10.1165/ajrcmb.22.4.3929;
RA   Zhang C., Sweezey N.B., Gagnon S., Muskat B., Koehler D., Post M.,
RA   Kaplan F.;
RT   "A novel karyopherin-beta homolog is developmentally and hormonally
RT   regulated in fetal lung.";
RL   Am. J. Respir. Cell Mol. Biol. 22:451-459(2000).
CC   -!- FUNCTION: Functions in nuclear protein import as nuclear transport
CC       receptor. Serves as receptor for nuclear localization signals (NLS) in
CC       cargo substrates. Is thought to mediate docking of the
CC       importin/substrate complex to the nuclear pore complex (NPC) through
CC       binding to nucleoporin and the complex is subsequently translocated
CC       through the pore by an energy requiring, Ran-dependent mechanism. At
CC       the nucleoplasmic side of the NPC, Ran binds to the importin, the
CC       importin/substrate complex dissociates and importin is re-exported from
CC       the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The
CC       directionality of nuclear import is thought to be conferred by an
CC       asymmetric distribution of the GTP- and GDP-bound forms of Ran between
CC       the cytoplasm and nucleus (By similarity). Mediates the nuclear import
CC       of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of
CC       the paired homeobox family. Also mediates nuclear export of eIF-1A, and
CC       the cytoplasmic release of eIF-1A is triggered by the loading of import
CC       substrates onto IPO13 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in fetal brain, heart, intestine and
CC       kidney. {ECO:0000269|PubMed:10745026}.
CC   -!- DEVELOPMENTAL STAGE: Differentially expressed in fetal lung with
CC       highest levels at gestational days 14 to 16.
CC       {ECO:0000269|PubMed:10745026}.
CC   -!- INDUCTION: By cortisol. {ECO:0000269|PubMed:10745026}.
CC   -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
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DR   EMBL; AF110195; AAF44721.1; -; mRNA.
DR   RefSeq; NP_446230.1; NM_053778.1.
DR   AlphaFoldDB; Q9JM04; -.
DR   SMR; Q9JM04; -.
DR   STRING; 10116.ENSRNOP00000026844; -.
DR   iPTMnet; Q9JM04; -.
DR   PhosphoSitePlus; Q9JM04; -.
DR   jPOST; Q9JM04; -.
DR   PaxDb; Q9JM04; -.
DR   PRIDE; Q9JM04; -.
DR   GeneID; 116458; -.
DR   KEGG; rno:116458; -.
DR   CTD; 9670; -.
DR   RGD; 620071; Ipo13.
DR   eggNOG; KOG2022; Eukaryota.
DR   InParanoid; Q9JM04; -.
DR   OrthoDB; 1032285at2759; -.
DR   PhylomeDB; Q9JM04; -.
DR   PRO; PR:Q9JM04; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR   GO; GO:0042564; C:NLS-dependent protein nuclear import complex; NAS:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0035259; F:nuclear glucocorticoid receptor binding; IPI:RGD.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IMP:RGD.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040709; Importin_rep_1.
DR   InterPro; IPR040944; Importin_rep_2.
DR   InterPro; IPR040520; Importin_rep_3.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF18773; Importin_rep; 1.
DR   Pfam; PF18786; Importin_rep_2; 2.
DR   Pfam; PF18806; Importin_rep_3; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW   Transport.
FT   CHAIN           1..963
FT                   /note="Importin-13"
FT                   /id="PRO_0000120760"
FT   REPEAT          24..54
FT                   /note="HEAT 1"
FT   DOMAIN          45..111
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT   REPEAT          56..88
FT                   /note="HEAT 2"
FT   REPEAT          95..135
FT                   /note="HEAT 3"
FT   REPEAT          142..179
FT                   /note="HEAT 4"
FT   REPEAT          194..231
FT                   /note="HEAT 5"
FT   REPEAT          236..268
FT                   /note="HEAT 6"
FT   REPEAT          276..325
FT                   /note="HEAT 7"
FT   REPEAT          330..372
FT                   /note="HEAT 8"
FT   REPEAT          375..438
FT                   /note="HEAT 9"
FT   REPEAT          440..476
FT                   /note="HEAT 10"
FT   REPEAT          487..522
FT                   /note="HEAT 11"
FT   REPEAT          524..558
FT                   /note="HEAT 12"
FT   REPEAT          562..600
FT                   /note="HEAT 13"
FT   REPEAT          603..648
FT                   /note="HEAT 14"
FT   REPEAT          676..716
FT                   /note="HEAT 15"
FT   REPEAT          720..754
FT                   /note="HEAT 16"
FT   REPEAT          761..803
FT                   /note="HEAT 17"
FT   REPEAT          815..845
FT                   /note="HEAT 18"
FT   REPEAT          860..893
FT                   /note="HEAT 19"
FT   REPEAT          897..931
FT                   /note="HEAT 20"
SQ   SEQUENCE   963 AA;  108187 MW;  35756A64B1DC9BCC CRC64;
     MERREEQLGA AGAGAAPALD FTVENVEKAL HQLYYDPNIE NKNLAQKWLM QAQVSPQAWH
     FSWQLLQPDK VPEIQYFGAS ALHIKISRYW SDIPTDQYES LKAHSFTQIT RFASGSKIVL
     TRLCVALASL ALSMMPDAWP CAVADMVRLF QAEDSPVDSQ GRCLALLELL TVLPEEFQTS
     RLPQYRKGLV RASLAVECGA VFPLLEQLLQ QPSSPSCVRQ KVLKCFSSWV QLEVPLQDCE
     ALIQAAFAAL QDSELFDSSV EAIVNAISQP DAQRYVNTLL KLIPLVLGLQ EQLRQAVQNG
     DMETSHGICR IAVALGENHS RALLDQVEHW QSFLALVNMI MFCTGIPGHY PVNETTSSLT
     LTFWYTLQDD ILSFEAEKQA VYQQVYRPVY FQLVDVLLHK AQFPSDEEYG FWSSDEKEQF
     RIYRVDISDT LMYVYEMLGA ELLSNLYDKL GRLLTSSEEP YSWQHTEALL YGFQSIAETI
     DVNYSDVVPG LIGLIPRISI SNVQLADTVM FTIGALSEWL ADHPVMINSV LPLVLHALGN
     PELSVSSVST LKKICRECKY ELPPYAANIV AVSQDVLMKQ IHKTSQCMWL MQALGFLLSA
     LQVEENLKNL HSLISTYIQQ LEKLAEEIPK PSNKLAIVHI LGLLSNLFTT LDVSHHEDDH
     EGPELRKLPV PQGPNPVVVV LQQVFQLIQK VLSKWLSDAQ VVEAVCAIFE KSVKTLLDDF
     APMVPQLCEM LGRMYSTVPQ ASALDLTRQL VHIFAHEPAH FPPIEALFLL VTSVTLSLFQ
     QGPRDHPDIV DSFMQLLAQA LKRKPDLFQC ERLDVKAVFQ CAVLALKFPE APTVKASCGF
     FTELLPRCGE IESVGKVVQE DGRMLLIAVL EAIGGQASRS LMDCFADILF ALNKHCFSLL
     SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL CRGLHGTDYT
     ADY