IPO5_DICDI
ID IPO5_DICDI Reviewed; 1067 AA.
AC Q54EW3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Probable importin-5 homolog;
DE AltName: Full=Importin subunit beta-3;
DE AltName: Full=Karyopherin beta-3;
GN ORFNames=DDB_G0291650;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Functions in nuclear protein import as nuclear transport
CC receptor. Serves as receptor for nuclear localization signals (NLS) in
CC cargo substrates (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-3
CC subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000177; EAL61809.1; -; Genomic_DNA.
DR RefSeq; XP_635127.1; XM_630035.1.
DR AlphaFoldDB; Q54EW3; -.
DR SMR; Q54EW3; -.
DR STRING; 44689.DDB0266483; -.
DR PaxDb; Q54EW3; -.
DR EnsemblProtists; EAL61809; EAL61809; DDB_G0291650.
DR GeneID; 8628073; -.
DR KEGG; ddi:DDB_G0291650; -.
DR dictyBase; DDB_G0291650; -.
DR eggNOG; KOG2171; Eukaryota.
DR HOGENOM; CLU_003794_0_1_1; -.
DR InParanoid; Q54EW3; -.
DR OMA; HHISIVE; -.
DR PhylomeDB; Q54EW3; -.
DR PRO; PR:Q54EW3; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR041653; Importin_rep_4.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR10527; PTHR10527; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF18808; Importin_rep_4; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW Transport.
FT CHAIN 1..1067
FT /note="Probable importin-5 homolog"
FT /id="PRO_0000328026"
FT REPEAT 3..34
FT /note="HEAT 1"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 42..75
FT /note="HEAT 2"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 93..120
FT /note="HEAT 3"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 125..152
FT /note="HEAT 4"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 164..197
FT /note="HEAT 5"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 206..243
FT /note="HEAT 6"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 251..286
FT /note="HEAT 7"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 295..347
FT /note="HEAT 8"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 349..381
FT /note="HEAT 9"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 385..425
FT /note="HEAT 10"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 427..466
FT /note="HEAT 11"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 468..508
FT /note="HEAT 12"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 510..553
FT /note="HEAT 13"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 555..596
FT /note="HEAT 14"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 598..658
FT /note="HEAT 15"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 661..703
FT /note="HEAT 16"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 718..757
FT /note="HEAT 17"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 763..826
FT /note="HEAT 18"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 832..869
FT /note="HEAT 19"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 876..909
FT /note="HEAT 20"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 917..960
FT /note="HEAT 21"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 969..999
FT /note="HEAT 22"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 1008..1040
FT /note="HEAT 23"
FT /evidence="ECO:0000250|UniProtKB:O00410"
FT REPEAT 1041..1064
FT /note="HEAT 24"
FT /evidence="ECO:0000250|UniProtKB:O00410"
SQ SEQUENCE 1067 AA; 120410 MW; 783F4E8A5538E04F CRC64;
MNLQPITDLL KALNSGNTTT IQQAEQLYAD YKNHQPDQLV NSFIVLIRTS QDELLRSYPP
VLLRTLVNGN DSGNILKGLK PETLVTLKTE LMFAVREEPK NHIRHSILNV IAILAIQLVP
EQKWPEILSF IIESSSSPEE NLRESSFYLI GAIIDDSRVA ETLAPHFDKF ALLVEKGLND
PSAKVQVSAL ETVSTFIDAN PEKAEVFKPL IPAMLNTIQK TIESNLEKEA QKGILTFIII
AQYHSDWFKT NFDMIFKVFF QFLEHQSLED ETKHACLHFF LTFAEFKSSI MKKKLYLEPI
VLLLLKWMSS VEDMDLKDWN SLDTEPSDDD DSNVAFEAIE ALSHCVSKGL WEFFLQCAPT
LLNSGNWKER YTGLMTLSSI SEGCEKQIKT NFKLIIQSIL PLANDSHPRV RFAFFYCLGS
FASYLKREMQ DLYKTLIPVS LEHLNDPFPR VTISNCEFLT LFLDEIKPNR VKEFKDQFLG
RLSPLLQNEN YKIVQHSLNA FSSVVDGIGE EFTQHYSEIM PFLIKILRTQ TSVETKTLRG
RAIETISLVG LAVGKKVFLN DCIQIIQYVS SLEKFKDDDP QVDFFLRAFT RFAQCLGEDF
IPYLKYSMSP LMDAINGKVD SSVENGEDFS DESNNSGSIV MENKAMALEM VSIYAMELKH
HLFPYVEQLY KGSIELVDFP FSSLVAIQAV NLIPFLVKIS KQHFEAVGGL KDGMKAEFTS
RLFLDSYERM AASIKTESEP DTLSAKLKAL SDLMDIGGQC EQADRILSLT FEVANESFGT
LQELETEYQE NIDEEDEDAD ESPEREIIDD AYNSLAMVLG EVCIQFKEKA VPYIATVLPA
MIELIETAPS VEIKTSMICI LDDLIENGGQ KAFELYPHII KPMMNCTLPN LDPSLIQSAV
FGIGLAAENG KDYFTPFLME SLQLINNVIV SVNSVQEQDD DLIAARDNAI SAMGRIITNL
PQHLGNNFPQ TIALWLSYLP IQDDGEAGSI IKSLCTLIRD FSQQIMTQQY IVKVLEIIAV
GLHKKAVNPD DKQIISLALR SQESLVAQSL FQLSAENQAI LANFFKN
