ID   IPO7_DICDI              Reviewed;        1065 AA.
AC   Q55CX9;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Probable importin-7 homolog;
GN   ORFNames=DDB_G0269860;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May function in nuclear protein import. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000005; EAL72280.1; -; Genomic_DNA.
DR   RefSeq; XP_646352.1; XM_641260.1.
DR   AlphaFoldDB; Q55CX9; -.
DR   SMR; Q55CX9; -.
DR   STRING; 44689.DDB0190623; -.
DR   PaxDb; Q55CX9; -.
DR   EnsemblProtists; EAL72280; EAL72280; DDB_G0269860.
DR   GeneID; 8617307; -.
DR   KEGG; ddi:DDB_G0269860; -.
DR   dictyBase; DDB_G0269860; -.
DR   eggNOG; KOG1991; Eukaryota.
DR   HOGENOM; CLU_004196_1_0_1; -.
DR   InParanoid; Q55CX9; -.
DR   OMA; LRPHAME; -.
DR   PhylomeDB; Q55CX9; -.
DR   PRO; PR:Q55CX9; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR013713; XPO2_central.
DR   Pfam; PF08506; Cse1; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1065
FT                   /note="Probable importin-7 homolog"
FT                   /id="PRO_0000342089"
FT   DOMAIN          25..98
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT   REGION          958..996
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        960..996
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1065 AA;  123614 MW;  16B4B0CD29449E3F CRC64;
     MDPIIQTIQL FQHTLHHDAN VIKAAEAQLQ QIKVTDGYSR ILLKILASNE VDISIRQGVS
     IFLKNMIITK WRGAEDESPI TQEDAEFIKE NLIDLLVHSH HLVQNQIEAM IEIIANRDFP
     EKWTSLLPKS IQYINTQDVK LILAGLTSIQ LGIKRFRYVT MGDKKKELLY TIVNEIFPLL
     LQILEFLSQH QTIESALMQK KVIKIFGYAI HFEIPDLLIQ PEVFNKWLSQ FVRIIQRPIT
     PQENVKHADD CRKNQWWLLK RTTAKLLNLL FRKSATSVRS TDHSSVKALN KLFMPVYSVE
     VMKVFYEQLS TLEQLYKGVH YERYQQKLIE YFSFAIKYGV TYVAMKPWLS TLIQQVLFPI
     ICFNDRDAEL WECDPNEFLR SQFESSMTFA TARIEVLNFI IDVVGKRGRA NLDMIMGFCI
     QSLNKYNAAT NASEKNPREK DGVLVIISVL SAYLKNISFY KSNLEQMLLL HVFPELSSPH
     GFLKARACSL FSEFYNIEFT DPVYFSNALK LILGLMSDND LPVRVKAGTS ICNLVRANQG
     VDELRPILPQ LLDKIFSLLS EAESEDLVIA IESIIQRFKH EIAPYAVNLC KNLSEQFLRL
     LELEESDESG ESGFASQECL GVYCTLLRAL KDIPDVFNSL EQQIVPILQK LFTSDHMMYL
     DEALRILTFV TYYPKSISPL VWSLFPQIMN LFDECACDFA SSYVNPLDNY ISYGTEYFLS
     NQQYIEMVFN MYKKMVGDIN QQPVDAGDCC KIMESLIQRA KGRIDYMIVP VLELACGRLL
     NTDKNNQKSK EFTVYLLEII ANCIYYNPLI STQYLESKNL VEPIFGLWFN RIKHFQRFYD
     KKISVLAFSS LLTLNPSPNF VKFGTSLILE KMLQFTKDML SIEKELDKQE AEREQKIKDG
     TLKPEEEEFI DENDEEDYFD NHKFEFEFTE IPDNQDCQHD DEGEVFLDDI EKATEYFENG
     GDLGEDEGDN FDDQNDDDDQ DSEEDLFEDE DTPDFETPID EVDGFEFMIN SIQNFFQINP
     TCIQQISEKQ QEKIKKYVAS APARKEKLRL EKEKEEKLKQ QQQKK