IPP2L_HUMAN
ID IPP2L_HUMAN Reviewed; 205 AA.
AC Q96PQ5;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Putative protein phosphatase inhibitor 2-like protein 1;
DE AltName: Full=Protein phosphatase 1, regulatory subunit 2 pseudogene 1;
GN Name=PPP1R2P1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11696978; DOI=10.3109/10425170109041335;
RA Wu I., Moses M.A.;
RT "Cloning of a cDNA encoding an isoform of human protein phosphatase
RT inhibitor 2 from vascularized breast tumor.";
RL DNA Seq. 11:515-518(2001).
CC -!- FUNCTION: Inhibitor of protein-phosphatase 1. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protein phosphatase inhibitor 2 family.
CC {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AF275684; AAL09300.1; -; mRNA.
DR AlphaFoldDB; Q96PQ5; -.
DR iPTMnet; Q96PQ5; -.
DR PhosphoSitePlus; Q96PQ5; -.
DR BioMuta; HGNC:9289; -.
DR jPOST; Q96PQ5; -.
DR MassIVE; Q96PQ5; -.
DR PeptideAtlas; Q96PQ5; -.
DR PRIDE; Q96PQ5; -.
DR ProteomicsDB; 77730; -.
DR GeneCards; PPP1R2P1; -.
DR HGNC; HGNC:9289; PPP1R2P1.
DR neXtProt; NX_Q96PQ5; -.
DR InParanoid; Q96PQ5; -.
DR PhylomeDB; Q96PQ5; -.
DR Pharos; Q96PQ5; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q96PQ5; protein.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IBA:GO_Central.
DR GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IBA:GO_Central.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR InterPro; IPR007062; PPI-2.
DR PANTHER; PTHR12398; PTHR12398; 1.
DR Pfam; PF04979; IPP-2; 1.
PE 5: Uncertain;
KW Carbohydrate metabolism; Glycogen metabolism; Phosphoprotein;
KW Protein phosphatase inhibitor; Reference proteome.
FT CHAIN 1..205
FT /note="Putative protein phosphatase inhibitor 2-like
FT protein 1"
FT /id="PRO_0000286137"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 12..17
FT /note="Required for binding PPP1CC"
FT /evidence="ECO:0000250"
FT REGION 43..55
FT /note="Required for binding PPP1CC"
FT /evidence="ECO:0000250"
FT REGION 64..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..150
FT /note="Required for binding PPP1CC catalytic center,
FT displacing metal ions and inhibition of PPP1CC catalytic
FT activity"
FT /evidence="ECO:0000250"
FT REGION 171..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 73
FT /note="Phosphothreonine; by GSK3"
FT /evidence="ECO:0000250"
FT MOD_RES 87
FT /note="Phosphoserine; by CK2"
FT /evidence="ECO:0000250"
SQ SEQUENCE 205 AA; 22863 MW; 8378DB68A6FDD378 CRC64;
MAASTASQRP LKGILKDNTS TTSSMVASAE HPRGSVHEQL SKKSQKWDEM NILATYRPAD
KDYGLMKIDE PSTPYHSTMG DDEDACSDTE TTEAMATDSL AKNLAAAEGL EPKYQVQEQE
SSGEEDSDLS PEEREKKRQF EMRRTLHYNE GLNIKLARQL ISKDLHDDDK VEEMLETAHG
ESMNTEESNQ GSTASDQQQN KSRSS
