IPP2_DICDI
ID IPP2_DICDI Reviewed; 261 AA.
AC Q86IZ4; Q555W8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Protein phosphatase inhibitor 2;
DE Short=IPP-2;
DE AltName: Full=DdI-2;
GN Name=dpiA; ORFNames=DDB_G0274315;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND INTERACTION
RP WITH PPPB.
RC STRAIN=AX4;
RX PubMed=17336445; DOI=10.1016/j.biochi.2007.01.002;
RA Sousa-Canavez J.M., Beton D., Gonzalez-Kristeller D.C., da Silva A.M.;
RT "Identification and domain mapping of Dictyostelium discoideum type-1
RT protein phosphatase inhibitor-2.";
RL Biochimie 89:692-701(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Inhibitor of protein-phosphatase 1 (PP1).
CC {ECO:0000269|PubMed:17336445}.
CC -!- SUBUNIT: Interacts with pppB. {ECO:0000269|PubMed:17336445}.
CC -!- DEVELOPMENTAL STAGE: Expressed at all stage of development with an
CC increase from 8 hours after starvation. {ECO:0000269|PubMed:17336445}.
CC -!- SIMILARITY: Belongs to the protein phosphatase inhibitor 2 family.
CC {ECO:0000305}.
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DR EMBL; DQ344638; ABC70201.1; -; mRNA.
DR EMBL; AAFI02000012; EAL70050.1; -; Genomic_DNA.
DR RefSeq; XP_643942.1; XM_638850.1.
DR AlphaFoldDB; Q86IZ4; -.
DR PaxDb; Q86IZ4; -.
DR EnsemblProtists; EAL70050; EAL70050; DDB_G0274315.
DR GeneID; 8619370; -.
DR KEGG; ddi:DDB_G0274315; -.
DR dictyBase; DDB_G0274315; dpiA.
DR eggNOG; ENOG502QYEH; Eukaryota.
DR HOGENOM; CLU_1067228_0_0_1; -.
DR InParanoid; Q86IZ4; -.
DR OMA; QQEKSEW; -.
DR PRO; PR:Q86IZ4; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IDA:dictyBase.
DR GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IDA:dictyBase.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR InterPro; IPR007062; PPI-2.
DR PANTHER; PTHR12398; PTHR12398; 1.
DR Pfam; PF04979; IPP-2; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Protein phosphatase inhibitor; Reference proteome.
FT CHAIN 1..261
FT /note="Protein phosphatase inhibitor 2"
FT /id="PRO_0000328375"
FT REGION 1..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1..150
FT /note="Required for binding to pppB"
FT COILED 150..242
FT /evidence="ECO:0000255"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..59
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 261 AA; 31091 MW; 06C0D5399AD4B99C CRC64;
MNKDEEFLEE HHYKDDDAIE GEEEQGEEEE SDLDDDMYNI DGETNDDDDD DEAEDEESSE
DEKQNQKFLY KKKRNLTKSS SNGEFKIIPY STLKGNTPTK GILKNKSQPP PKKNRIVWDE
ENLTINDMNK SSTMKIDEPK TPYHYYESEE ETDESKKYLE NKFLELQNAL DKQQEKSEWD
SDNDEQQQEK EKEKDKKKKK KNLKIHMRSD SDDNDDNEDE DEDETEEKKE NKKKFDNLRK
AHYNEFKVVR DLNANLSDDE Q
