IPP_MOUSE
ID IPP_MOUSE Reviewed; 584 AA.
AC P28575; Q3V2M0;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Actin-binding protein IPP;
DE AltName: Full=Intracisternal A particle-promoted polypeptide;
DE Short=IPP;
DE AltName: Full=Murine IAP-promoted placenta-expressed protein;
DE AltName: Full=Protein MIPP;
GN Name=Ipp; Synonyms=Mipp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=11536049; DOI=10.1038/sj.onc.1204701;
RA VanHouten J.N., Asch H.L., Asch B.B.;
RT "Cloning and characterization of ectopically expressed transcripts for the
RT actin-binding protein MIPP in mouse mammary carcinomas.";
RL Oncogene 20:5366-5372(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 355-556.
RX PubMed=1906605; DOI=10.1093/nar/19.13.3667;
RA Chang-Yeh A., Mold D.E., Huang R.C.C.;
RT "Identification of a novel murine IAP-promoted placenta-expressed gene.";
RL Nucleic Acids Res. 19:3667-3672(1991).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=1905535; DOI=10.1016/0006-291x(91)90646-o;
RA Mold D.E., Chang-Yeh A., Huang R.C.;
RT "Cell lineage-specific expression of the MIPP gene.";
RL Biochem. Biophys. Res. Commun. 177:1062-1067(1991).
CC -!- FUNCTION: May play a role in organizing the actin cytoskeleton.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- TISSUE SPECIFICITY: Expression seems confined to tissues derived from
CC trophectoderm and primitive endoderm. {ECO:0000269|PubMed:1905535}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK00278.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA41413.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA41414.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF285178; AAK00278.1; ALT_FRAME; mRNA.
DR EMBL; AK131718; BAE20777.1; -; mRNA.
DR EMBL; AL669953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X58523; CAA41413.1; ALT_FRAME; mRNA.
DR EMBL; X58524; CAA41414.1; ALT_FRAME; Genomic_DNA.
DR CCDS; CCDS38851.1; -.
DR PIR; S16442; S16442.
DR RefSeq; NP_032415.2; NM_008389.3.
DR AlphaFoldDB; P28575; -.
DR SMR; P28575; -.
DR BioGRID; 200781; 1.
DR STRING; 10090.ENSMUSP00000102088; -.
DR iPTMnet; P28575; -.
DR PhosphoSitePlus; P28575; -.
DR EPD; P28575; -.
DR PaxDb; P28575; -.
DR PRIDE; P28575; -.
DR ProteomicsDB; 301661; -.
DR Antibodypedia; 32715; 70 antibodies from 17 providers.
DR DNASU; 16351; -.
DR Ensembl; ENSMUST00000030461; ENSMUSP00000030461; ENSMUSG00000028696.
DR Ensembl; ENSMUST00000106479; ENSMUSP00000102088; ENSMUSG00000028696.
DR GeneID; 16351; -.
DR KEGG; mmu:16351; -.
DR UCSC; uc008ugp.1; mouse.
DR CTD; 3652; -.
DR MGI; MGI:96581; Ipp.
DR VEuPathDB; HostDB:ENSMUSG00000028696; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000158629; -.
DR HOGENOM; CLU_004253_14_1_1; -.
DR InParanoid; P28575; -.
DR OMA; QAAYNWI; -.
DR OrthoDB; 938011at2759; -.
DR PhylomeDB; P28575; -.
DR TreeFam; TF329218; -.
DR BioGRID-ORCS; 16351; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Ipp; mouse.
DR PRO; PR:P28575; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P28575; protein.
DR Bgee; ENSMUSG00000028696; Expressed in secondary oocyte and 202 other tissues.
DR Genevisible; P28575; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.80; -; 2.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR030104; IPP.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF35; PTHR24412:SF35; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; SSF117281; 2.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Cytoplasm; Cytoskeleton; Kelch repeat; Reference proteome;
KW Repeat.
FT CHAIN 1..584
FT /note="Actin-binding protein IPP"
FT /id="PRO_0000119076"
FT DOMAIN 37..104
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 296..343
FT /note="Kelch 1"
FT REPEAT 344..390
FT /note="Kelch 2"
FT REPEAT 391..437
FT /note="Kelch 3"
FT REPEAT 439..485
FT /note="Kelch 4"
FT REPEAT 487..533
FT /note="Kelch 5"
FT REPEAT 535..583
FT /note="Kelch 6"
FT CONFLICT 6..7
FT /note="CP -> YA (in Ref. 1; AAK00278)"
FT /evidence="ECO:0000305"
FT CONFLICT 12
FT /note="N -> S (in Ref. 1; AAK00278)"
FT /evidence="ECO:0000305"
FT CONFLICT 32
FT /note="S -> T (in Ref. 1; AAK00278)"
FT /evidence="ECO:0000305"
FT CONFLICT 59
FT /note="S -> K (in Ref. 1; AAK00278)"
FT /evidence="ECO:0000305"
FT CONFLICT 164..165
FT /note="VH -> SI (in Ref. 1; AAK00278)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 584 AA; 65216 MW; BE8CE11A53F7CFED CRC64;
MSKEECPKAA DNSFSSDKHA QLILAQMNKM RSGQHFCDVQ LQVGKETFQV HRLVLAASSP
YFAALFTGGM KESSKDVVQI LGVEAGIFQL LLDFIYTGVV NIAVTNVQEL IVAADMLQLT
EVVNLCCDFL KGQIDPQNCI GLFQFSEQIA CHDLLEFTEN YIHVHFLEVH TGEEFLGLTK
DQLIKILRSE ELSIEDEYQV FLAAMQWILK DLGKRRKHVV EVLDPVRFPL LPSQRLLKYI
EGVSDFNLRV ALQTLLKEYC EVCKSPKENK FCSFLQTSKV RPRKKARKYL YAVGGYTRLQ
GGRWSDSRAL SCVERFDTFS QYWTTVSSLH QARCGLGVAV VGGMVYAIGG EKDSMIFDCT
ECYDPVTKQW TTVASMNHPR CGLGVCVCYG AIYALGGWVG AEIGNTIERF DPDENKWEVV
GSMAVSRYYF GCCEMQGLIY AVGGISNEGL ELRSFEVYDP LSKRWSPLPP MGTRRAYLGV
AALNDCIYAI GGWNETQDAL HTVEKYSFEE EKWVEVASMK VPRAGMCAVT VNGLLYVSGG
RSSSHDFLAP GTLDSVEVYN PHSDTWTEIG NMITSRCEGG VAVL
