ID   IPRA_ECO57              Reviewed;         207 AA.
AC   P0AAP6; P77723;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Inhibitor of hydrogen peroxide resistance {ECO:0000255|HAMAP-Rule:MF_02072};
GN   Name=iprA {ECO:0000255|HAMAP-Rule:MF_02072}; Synonyms=yaiV;
GN   OrderedLocusNames=Z0470, ECs0425;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Involved in oxidative stress resistance. {ECO:0000255|HAMAP-
CC       Rule:MF_02072}.
CC   -!- SIMILARITY: Belongs to the IprA family. {ECO:0000255|HAMAP-
CC       Rule:MF_02072}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG54721.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB33848.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG54721.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB33848.1; ALT_INIT; Genomic_DNA.
DR   PIR; A90682; A90682.
DR   PIR; E85532; E85532.
DR   RefSeq; NP_308452.2; NC_002695.1.
DR   RefSeq; WP_001295335.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0AAP6; -.
DR   SMR; P0AAP6; -.
DR   STRING; 155864.EDL933_0432; -.
DR   EnsemblBacteria; AAG54721; AAG54721; Z0470.
DR   EnsemblBacteria; BAB33848; BAB33848; ECs_0425.
DR   GeneID; 914527; -.
DR   KEGG; ece:Z0470; -.
DR   KEGG; ecs:ECs_0425; -.
DR   PATRIC; fig|386585.9.peg.520; -.
DR   eggNOG; COG0664; Bacteria.
DR   HOGENOM; CLU_080453_0_0_6; -.
DR   OMA; MAEWDET; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 1.
DR   HAMAP; MF_02072; IprA; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR041687; HTH_46.
DR   InterPro; IPR034719; IprA.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF15977; HTH_46; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Stress response.
FT   CHAIN           1..207
FT                   /note="Inhibitor of hydrogen peroxide resistance"
FT                   /id="PRO_0000168597"
FT   DNA_BIND        163..182
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02072"
SQ   SEQUENCE   207 AA;  23956 MW;  E58258DC6F00E505 CRC64;
     MLSVVKPLQE FGKLDKCLSR YGTRFEFNNE KQVIFSSDVN NEDTFVILEG VISLRREENV
     LIGITQAPYI MGLADGLMKN DIPYKLISEG NCTGYHLPAK QTITLIEQNQ LWRDAFYWLA
     WQNRILELRD VQLIGHNSYE QIRATLLSMI DWNEELRSRI GVMNYIHQRT RISRSVVAEV
     LAALRKGGYI EMNKGKLVAI NRLPSEY