ID   IPRA_ECOLI              Reviewed;         207 AA.
AC   P0AAP5; P77723; Q2MC50;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Inhibitor of hydrogen peroxide resistance {ECO:0000255|HAMAP-Rule:MF_02072};
GN   Name=iprA {ECO:0000255|HAMAP-Rule:MF_02072}; Synonyms=yaiV;
GN   OrderedLocusNames=b0375, JW0366;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=27246569; DOI=10.1128/jb.00144-16;
RA   Herman A., Serfecz J., Kinnally A., Crosby K., Youngman M., Wykoff D.,
RA   Wilson J.W.;
RT   "The bacterial iprA gene is conserved across Enterobacteriaceae, is
RT   involved in oxidative stress resistance, and influences gene expression in
RT   Salmonella enterica serovar typhimurium.";
RL   J. Bacteriol. 198:2166-2179(2016).
CC   -!- FUNCTION: Involved in oxidative stress resistance. {ECO:0000255|HAMAP-
CC       Rule:MF_02072}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutants display increased resistance to
CC       oxidative stress and increased catalase activity.
CC       {ECO:0000269|PubMed:27246569}.
CC   -!- SIMILARITY: Belongs to the IprA family. {ECO:0000255|HAMAP-
CC       Rule:MF_02072}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB18098.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAE76156.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U73857; AAB18098.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC73478.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76156.1; ALT_INIT; Genomic_DNA.
DR   PIR; G64765; G64765.
DR   RefSeq; NP_414909.2; NC_000913.3.
DR   RefSeq; WP_001295335.1; NZ_STEB01000007.1.
DR   AlphaFoldDB; P0AAP5; -.
DR   SMR; P0AAP5; -.
DR   BioGRID; 4259481; 153.
DR   IntAct; P0AAP5; 3.
DR   STRING; 511145.b0375; -.
DR   PaxDb; P0AAP5; -.
DR   PRIDE; P0AAP5; -.
DR   EnsemblBacteria; AAC73478; AAC73478; b0375.
DR   EnsemblBacteria; BAE76156; BAE76156; BAE76156.
DR   GeneID; 946902; -.
DR   KEGG; ecj:JW0366; -.
DR   KEGG; eco:b0375; -.
DR   PATRIC; fig|1411691.4.peg.1904; -.
DR   EchoBASE; EB3374; -.
DR   eggNOG; COG0664; Bacteria.
DR   HOGENOM; CLU_080453_0_0_6; -.
DR   PhylomeDB; P0AAP5; -.
DR   BioCyc; EcoCyc:G6226-MON; -.
DR   PRO; PR:P0AAP5; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 1.
DR   HAMAP; MF_02072; IprA; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR041687; HTH_46.
DR   InterPro; IPR034719; IprA.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF15977; HTH_46; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Stress response.
FT   CHAIN           1..207
FT                   /note="Inhibitor of hydrogen peroxide resistance"
FT                   /id="PRO_0000168596"
FT   DNA_BIND        163..182
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02072"
SQ   SEQUENCE   207 AA;  23956 MW;  E58258DC6F00E505 CRC64;
     MLSVVKPLQE FGKLDKCLSR YGTRFEFNNE KQVIFSSDVN NEDTFVILEG VISLRREENV
     LIGITQAPYI MGLADGLMKN DIPYKLISEG NCTGYHLPAK QTITLIEQNQ LWRDAFYWLA
     WQNRILELRD VQLIGHNSYE QIRATLLSMI DWNEELRSRI GVMNYIHQRT RISRSVVAEV
     LAALRKGGYI EMNKGKLVAI NRLPSEY