ID   IPRI_BOVIN              Reviewed;         556 AA.
AC   A7MB64;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein;
DE   Flags: Precursor;
GN   Name=ITPRIP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-
CC       triphosphate receptor (ITPR) Ca(2+) release.
CC       {ECO:0000250|UniProtKB:Q8IWB1}.
CC   -!- SUBUNIT: Interacts with ITPR. {ECO:0000250|UniProtKB:Q8IWB1}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IWB1};
CC       Single-pass type I membrane protein {ECO:0000255}. Nucleus outer
CC       membrane {ECO:0000250|UniProtKB:Q3TNL8}; Single-pass type I membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ITPRIP family. {ECO:0000305}.
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DR   EMBL; BC151359; AAI51360.1; -; mRNA.
DR   RefSeq; NP_001094648.1; NM_001101178.1.
DR   RefSeq; XP_005225647.1; XM_005225590.3.
DR   RefSeq; XP_005225649.1; XM_005225592.3.
DR   RefSeq; XP_010818213.1; XM_010819911.2.
DR   AlphaFoldDB; A7MB64; -.
DR   STRING; 9913.ENSBTAP00000005212; -.
DR   PaxDb; A7MB64; -.
DR   PRIDE; A7MB64; -.
DR   Ensembl; ENSBTAT00000005212; ENSBTAP00000005212; ENSBTAG00000003990.
DR   GeneID; 538685; -.
DR   KEGG; bta:538685; -.
DR   CTD; 85450; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003990; -.
DR   VGNC; VGNC:30349; ITPRIP.
DR   eggNOG; ENOG502QRDF; Eukaryota.
DR   GeneTree; ENSGT01050000244827; -.
DR   HOGENOM; CLU_025485_2_0_1; -.
DR   InParanoid; A7MB64; -.
DR   OMA; CHLHCLQ; -.
DR   OrthoDB; 378719at2759; -.
DR   TreeFam; TF332277; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000003990; Expressed in neutrophil and 104 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005640; C:nuclear outer membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR   GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR   GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR   InterPro; IPR024797; IP3R-int.
DR   InterPro; IPR026250; ITPRIP_fam.
DR   InterPro; IPR024810; Mab-21_dom.
DR   PANTHER; PTHR10656:SF8; PTHR10656:SF8; 1.
DR   Pfam; PF03281; Mab-21; 1.
DR   PRINTS; PR02107; INOS145TPRIP.
DR   SMART; SM01265; Mab-21; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Glycoprotein; Membrane; Nucleus;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..556
FT                   /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT                   protein"
FT                   /id="PRO_0000320569"
FT   TOPO_DOM        16..88
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..556
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   COILED          32..87
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        27
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   556 AA;  63432 MW;  01A0AB9C31B808CC CRC64;
     MALGLFRVCL VVVTAIINHP LLFPRENTTV PENEEEIIRQ MQAHQEKLQL EQLRLEEEMA
     RLAADKEAEK EALERVAEEG QQQNESRTAW DLWSTLCMIL FLVIEVWRQD HQDAPSPECL
     GSDEDELPDL EGAPLRGLTL PNRATLDHFY ERCIRGATAD AARTREFVEG FVDDLLEALR
     SLCSRDSDME VEDFIGVDSM YENWQVNKPL LCDLFVPFMP PEPYHFHPEL WCSSRSVPLD
     RQGYGQIKVV RADEDTLGCI CGKTKLGEDM LCLLHGRNNV VHHGSKAADP LCAPNSPYLD
     TMRVMKWFQT ALTRAWHRIE HKYEFDLAFG QLDTPGSLKI RFRSGKFMPF NLIPVIQCDD
     SDLYFVSHLA REPGGGTRAS STDWLLSFAV YERHFLRVTS KALPEGACHL SCLQIASFLL
     SKQSRLTGPS GLGSYHLKTA LLHLLLARRP ADWKAEQLDA RLHELLCFLE KSLLEKKLQH
     FFIGNRKVPQ AMGLPEAVRR AEPLNLFRPF VLQRSLYRKT VDSFYEMLKN APALISEYSL
     HIPSDHASLP PKTVIL