ID   IPRI_DANRE              Reviewed;         539 AA.
AC   Q567X9;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein;
DE   Flags: Precursor;
GN   Name=itprip; ORFNames=zgc:110677;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-
CC       triphosphate receptor (ITPR) Ca(2+) release.
CC       {ECO:0000250|UniProtKB:Q8IWB1}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IWB1};
CC       Single-pass type I membrane protein {ECO:0000255}. Nucleus outer
CC       membrane {ECO:0000250|UniProtKB:Q3TNL8}; Single-pass type I membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ITPRIP family. {ECO:0000305}.
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DR   EMBL; BC092976; AAH92976.1; -; mRNA.
DR   RefSeq; NP_001017872.1; NM_001017872.1.
DR   AlphaFoldDB; Q567X9; -.
DR   STRING; 7955.ENSDARP00000009775; -.
DR   PaxDb; Q567X9; -.
DR   GeneID; 550570; -.
DR   KEGG; dre:550570; -.
DR   CTD; 85450; -.
DR   ZFIN; ZDB-GENE-050417-422; itprip.
DR   eggNOG; ENOG502QRDF; Eukaryota.
DR   InParanoid; Q567X9; -.
DR   OrthoDB; 378719at2759; -.
DR   PhylomeDB; Q567X9; -.
DR   PRO; PR:Q567X9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005640; C:nuclear outer membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024797; IP3R-int.
DR   InterPro; IPR026250; ITPRIP_fam.
DR   InterPro; IPR024810; Mab-21_dom.
DR   PANTHER; PTHR10656:SF8; PTHR10656:SF8; 1.
DR   Pfam; PF03281; Mab-21; 1.
DR   PRINTS; PR02107; INOS145TPRIP.
DR   SMART; SM01265; Mab-21; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Glycoprotein; Membrane; Nucleus;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..539
FT                   /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT                   protein"
FT                   /id="PRO_0000293730"
FT   TOPO_DOM        25..71
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..539
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   COILED          32..68
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        27
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   539 AA;  61362 MW;  71A9472F1CC85997 CRC64;
     MQGAIARVCM VVVAAILNHP LLFPNENTTV PEQDEDLLAR MKEHQEKLEA EQKRLEQEIS
     QNETSVIGDQ DGYGWYFWSA LCLVIFFTIE VCRQDLISAE IPDPAEDEDG DCSTGYHSAK
     SIALDRGTLN NFCKTRFFPY TNESGRVREF IEGFADDLLE ALRSICDLKA DLEVEDFAGI
     GSMFESWRVS KPPTCDLIVP FSPPQPLRFQ FELWCDPSTE IPLDLQGCGR IQLIKPGGNG
     TDCLCGSIDL GDDMLCLLHN RNECEVLEDD ALPELLCARD TTYLSKGQIM RWFQISVSKA
     WGKISHKYDF ELAFRNLDFP GALKIKFPSG KTVVLNLTPA VQFENTDAYL ISHFPSDTSN
     SSDTHWQLSL SVYEKNLLKH LAKSLPTNSC HIHCLQIVAF LHKKQTTLTG RSAFCNYHIK
     TALLHLLLSK RPAMWQPQNL DSRLRDLLSF LQQSLEEKKL YHALVGNPRI PVEILVPKII
     RTAEPINLYR PLVLQRHVYA KMEEHFEEMV RNTSVLVQEY TPHFSNGHVR HEFSSAEQI