IPRI_HUMAN
ID IPRI_HUMAN Reviewed; 547 AA.
AC Q8IWB1; D3DRA5; Q5JU17; Q96MS8; Q9C0A9;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein;
DE AltName: Full=Protein DANGER;
DE Flags: Precursor;
GN Name=ITPRIP; Synonyms=DANGER, KIAA1754;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16990268; DOI=10.1074/jbc.m608760200;
RA van Rossum D.B., Patterson R.L., Cheung K.-H., Barrow R.K., Syrovatkina V.,
RA Gessell G.S., Burkholder S.G., Watkins D.N., Foskett J.K., Snyder S.H.;
RT "DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-
RT receptor activity.";
RL J. Biol. Chem. 281:37111-37116(2006).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-547, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-
CC triphosphate receptor (ITPR) Ca(2+) release.
CC {ECO:0000269|PubMed:16990268}.
CC -!- SUBUNIT: Interacts with ITPR. {ECO:0000269|PubMed:16990268}.
CC -!- INTERACTION:
CC Q8IWB1; Q9NZ94-2: NLGN3; NbExp=5; IntAct=EBI-2556412, EBI-16423037;
CC Q8IWB1; O15173: PGRMC2; NbExp=3; IntAct=EBI-2556412, EBI-1050125;
CC Q8IWB1; Q86WH2: RASSF3; NbExp=3; IntAct=EBI-2556412, EBI-2845202;
CC Q8IWB1; Q96EQ0: SGTB; NbExp=3; IntAct=EBI-2556412, EBI-744081;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16990268};
CC Single-pass type I membrane protein. Nucleus outer membrane
CC {ECO:0000250|UniProtKB:Q3TNL8}; Single-pass type I membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Detected in brain where it is concentrated in
CC cerebellar Purkinje cells (at protein level).
CC {ECO:0000269|PubMed:16990268}.
CC -!- SIMILARITY: Belongs to the ITPRIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB21845.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB051541; BAB21845.1; ALT_INIT; mRNA.
DR EMBL; AK056526; BAB71204.1; -; mRNA.
DR EMBL; AL162742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW49596.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49597.1; -; Genomic_DNA.
DR EMBL; BC040536; AAH40536.1; -; mRNA.
DR EMBL; BC070108; AAH70108.1; -; mRNA.
DR CCDS; CCDS7557.1; -.
DR RefSeq; NP_001258941.1; NM_001272012.1.
DR RefSeq; NP_001258942.1; NM_001272013.1.
DR RefSeq; NP_203755.1; NM_033397.3.
DR AlphaFoldDB; Q8IWB1; -.
DR BioGRID; 124535; 58.
DR IntAct; Q8IWB1; 27.
DR STRING; 9606.ENSP00000278071; -.
DR GlyGen; Q8IWB1; 2 sites.
DR iPTMnet; Q8IWB1; -.
DR PhosphoSitePlus; Q8IWB1; -.
DR BioMuta; ITPRIP; -.
DR DMDM; 74750704; -.
DR EPD; Q8IWB1; -.
DR jPOST; Q8IWB1; -.
DR MassIVE; Q8IWB1; -.
DR MaxQB; Q8IWB1; -.
DR PaxDb; Q8IWB1; -.
DR PeptideAtlas; Q8IWB1; -.
DR PRIDE; Q8IWB1; -.
DR ProteomicsDB; 70833; -.
DR TopDownProteomics; Q8IWB1; -.
DR Antibodypedia; 48978; 48 antibodies from 15 providers.
DR DNASU; 85450; -.
DR Ensembl; ENST00000278071.6; ENSP00000278071.2; ENSG00000148841.17.
DR Ensembl; ENST00000337478.3; ENSP00000337178.1; ENSG00000148841.17.
DR Ensembl; ENST00000358187.2; ENSP00000350915.2; ENSG00000148841.17.
DR Ensembl; ENST00000647721.1; ENSP00000497746.1; ENSG00000148841.17.
DR GeneID; 85450; -.
DR KEGG; hsa:85450; -.
DR MANE-Select; ENST00000337478.3; ENSP00000337178.1; NM_001272013.2; NP_001258942.1.
DR UCSC; uc001kye.5; human.
DR CTD; 85450; -.
DR DisGeNET; 85450; -.
DR GeneCards; ITPRIP; -.
DR HGNC; HGNC:29370; ITPRIP.
DR HPA; ENSG00000148841; Tissue enhanced (bone).
DR neXtProt; NX_Q8IWB1; -.
DR OpenTargets; ENSG00000148841; -.
DR PharmGKB; PA162392344; -.
DR VEuPathDB; HostDB:ENSG00000148841; -.
DR eggNOG; ENOG502QRDF; Eukaryota.
DR GeneTree; ENSGT01050000244827; -.
DR HOGENOM; CLU_025485_2_0_1; -.
DR InParanoid; Q8IWB1; -.
DR OMA; CHLHCLQ; -.
DR OrthoDB; 378719at2759; -.
DR PhylomeDB; Q8IWB1; -.
DR TreeFam; TF332277; -.
DR PathwayCommons; Q8IWB1; -.
DR SignaLink; Q8IWB1; -.
DR BioGRID-ORCS; 85450; 15 hits in 1077 CRISPR screens.
DR ChiTaRS; ITPRIP; human.
DR GenomeRNAi; 85450; -.
DR Pharos; Q8IWB1; Tdark.
DR PRO; PR:Q8IWB1; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8IWB1; protein.
DR Bgee; ENSG00000148841; Expressed in stromal cell of endometrium and 110 other tissues.
DR ExpressionAtlas; Q8IWB1; baseline and differential.
DR Genevisible; Q8IWB1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005640; C:nuclear outer membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR InterPro; IPR024797; IP3R-int.
DR InterPro; IPR026250; ITPRIP_fam.
DR InterPro; IPR024810; Mab-21_dom.
DR PANTHER; PTHR10656:SF8; PTHR10656:SF8; 1.
DR Pfam; PF03281; Mab-21; 1.
DR PRINTS; PR02107; INOS145TPRIP.
DR SMART; SM01265; Mab-21; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Coiled coil; Glycoprotein; Membrane; Nucleus;
KW Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..547
FT /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT protein"
FT /id="PRO_0000293728"
FT TOPO_DOM 16..83
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..547
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 109..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 32..82
FT /evidence="ECO:0000255"
FT MOD_RES 547
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 547 AA; 62060 MW; 7DDD6CA06FE494AA CRC64;
MAMGLFRVCL VVVTAIINHP LLFPRENATV PENEEEIIRK MQAHQEKLQL EQLRLEEEVA
RLAAEKEALE QVAEEGRQQN ETRVAWDLWS TLCMILFLMI EVWRQDHQEG PSPECLGGEE
DELPGLGGAP LQGLTLPNKA TLGHFYERCI RGATADAART REFLEGFVDD LLEALRSLCN
RDTDMEVEDF IGVDSMYENW QVDRPLLCHL FVPFTPPEPY RFHPELWCSG RSVPLDRQGY
GQIKVVRADG DTLSCICGKT KLGEDMLCLL HGRNSMAPPC GDMENLLCAT DSLYLDTMQV
MKWFQTALTR AWKGIAHKYE FDLAFGQLDS PGSLKIKFRS GKFMPFNLIP VIQCDDSDLY
FVSHLPREPS EGTPASSTDW LLSFAVYERH FLRTTLKALP EGACHLSCLQ IASFLLSKQS
RLTGPSGLSS YHLKTALLHL LLLRQAADWK AGQLDARLHE LLCFLEKSLL QKKLHHFFIG
NRKVPEAMGL PEAVLRAEPL NLFRPFVLQR SLYRKTLDSF YEMLKNAPAL ISEYSLHVPS
DQPTPKS
