IPRI_MOUSE
ID IPRI_MOUSE Reviewed; 555 AA.
AC Q3TNL8; Q3TAD9; Q3TB01; Q571G7; Q6P400;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein;
DE Flags: Precursor;
GN Name=Itprip; Synonyms=Kiaa1754;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Dendritic cell, Embryo, Head, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=31142202; DOI=10.1080/19491034.2019.1618175;
RA Cheng L.C., Baboo S., Lindsay C., Brusman L., Martinez-Bartolome S.,
RA Tapia O., Zhang X., Yates J.R. III, Gerace L.;
RT "Identification of new transmembrane proteins concentrated at the nuclear
RT envelope using organellar proteomics of mesenchymal cells.";
RL Nucleus 10:126-143(2019).
CC -!- FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-
CC triphosphate receptor (ITPR) Ca(2+) release.
CC {ECO:0000250|UniProtKB:Q8IWB1}.
CC -!- SUBUNIT: Interacts with ITPR. {ECO:0000250|UniProtKB:Q8IWB1}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IWB1};
CC Single-pass type I membrane protein {ECO:0000255}. Nucleus outer
CC membrane {ECO:0000269|PubMed:31142202}; Single-pass type I membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3TNL8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TNL8-2; Sequence=VSP_026571;
CC -!- SIMILARITY: Belongs to the ITPRIP family. {ECO:0000305}.
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DR EMBL; AK160686; BAE35957.1; -; mRNA.
DR EMBL; AK165192; BAE38070.1; -; mRNA.
DR EMBL; AK171522; BAE42505.1; -; mRNA.
DR EMBL; AK171539; BAE42513.1; -; mRNA.
DR EMBL; AK171911; BAE42729.1; -; mRNA.
DR EMBL; AK220222; BAD90147.1; -; mRNA.
DR EMBL; BC063749; AAH63749.1; -; mRNA.
DR CCDS; CCDS29895.1; -. [Q3TNL8-1]
DR RefSeq; NP_001001738.2; NM_001001738.2. [Q3TNL8-1]
DR RefSeq; XP_006527237.1; XM_006527174.1.
DR RefSeq; XP_006527238.1; XM_006527175.1.
DR AlphaFoldDB; Q3TNL8; -.
DR BioGRID; 240591; 1.
DR IntAct; Q3TNL8; 1.
DR GlyGen; Q3TNL8; 1 site.
DR iPTMnet; Q3TNL8; -.
DR PhosphoSitePlus; Q3TNL8; -.
DR EPD; Q3TNL8; -.
DR jPOST; Q3TNL8; -.
DR MaxQB; Q3TNL8; -.
DR PaxDb; Q3TNL8; -.
DR PeptideAtlas; Q3TNL8; -.
DR PRIDE; Q3TNL8; -.
DR ProteomicsDB; 301662; -. [Q3TNL8-1]
DR ProteomicsDB; 301663; -. [Q3TNL8-2]
DR Antibodypedia; 48978; 48 antibodies from 15 providers.
DR DNASU; 414801; -.
DR Ensembl; ENSMUST00000095998; ENSMUSP00000093697; ENSMUSG00000117975. [Q3TNL8-1]
DR GeneID; 414801; -.
DR KEGG; mmu:414801; -.
DR UCSC; uc008hvu.1; mouse. [Q3TNL8-1]
DR CTD; 85450; -.
DR MGI; MGI:3042776; Itprip.
DR VEuPathDB; HostDB:ENSMUSG00000117975; -.
DR GeneTree; ENSGT01050000244827; -.
DR HOGENOM; CLU_025485_2_0_1; -.
DR InParanoid; Q3TNL8; -.
DR OMA; CHLHCLQ; -.
DR OrthoDB; 378719at2759; -.
DR PhylomeDB; Q3TNL8; -.
DR TreeFam; TF332277; -.
DR BioGRID-ORCS; 414801; 1 hit in 43 CRISPR screens.
DR ChiTaRS; Itprip; mouse.
DR PRO; PR:Q3TNL8; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q3TNL8; protein.
DR Bgee; ENSMUSG00000117975; Expressed in granulocyte and 133 other tissues.
DR ExpressionAtlas; Q3TNL8; baseline and differential.
DR Genevisible; Q3TNL8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005640; C:nuclear outer membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IDA:MGI.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IGI:MGI.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IGI:MGI.
DR InterPro; IPR024797; IP3R-int.
DR InterPro; IPR026250; ITPRIP_fam.
DR InterPro; IPR024810; Mab-21_dom.
DR PANTHER; PTHR10656:SF8; PTHR10656:SF8; 1.
DR Pfam; PF03281; Mab-21; 1.
DR PRINTS; PR02107; INOS145TPRIP.
DR SMART; SM01265; Mab-21; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Coiled coil; Glycoprotein; Membrane;
KW Nucleus; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..555
FT /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT protein"
FT /id="PRO_0000293729"
FT TOPO_DOM 16..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..555
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT COILED 32..84
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 218..224
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026571"
FT CONFLICT 275
FT /note="G -> E (in Ref. 1; BAE42729)"
FT /evidence="ECO:0000305"
FT CONFLICT 355
FT /note="I -> T (in Ref. 1; BAE42729)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 555 AA; 63238 MW; CD8832F1458980F7 CRC64;
MAMELFRVCL VVVTAIINHP LLFPRENATI PENEEEIIRK MQEHQEKLRL EQLRLEEEVS
RLEAEKEALR QVEEEQQQLE AHTAWDLWTT LCMVLFLIIE VLRQNHQEGT FPECLGGDED
ELSGLGGTLL QGLPLPNRAT LDHFYEHCIR STTGDATRTQ EFVEGFVDDL LEALRSTYNG
KTDMELEDFI GVGSMYENWQ VERPLRCHLF IPFIPPEPYS FHPEFWCSSL STPLERQGYG
QIKVTLADGN PLGCVCGKAK LEEDMLCLLY GKNRGAWPSS AGCGEMEGLL CSRESSYLDV
MQVMKWFQMA LTRAWHRIAH KYEFDLAFGE LDTPGSLKIK FRSGKSMPFI LTPVIQCNDS
DLYFILQLPK EPCGGGPASS AHWLLSFAVY EREFLRMTGK ALPEGACHLS CLQIASFLLS
KQTRLTGPSG LSDYHLKTAL LHLLLSRQAS DWKASKLDVR LQDLFCFLER SLLEKKLYHF
FMGNHKVPEA LGLPEVVRRA EPLNLFRPFV LQRTLYRNTV DSFYEMLKNA PALISEYSLH
VPSVRASPPP KAVVS
