ID   IPRI_TAKRU              Reviewed;         534 AA.
AC   Q90XY5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein;
DE   Flags: Precursor;
GN   Name=itprip;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11571655; DOI=10.1038/sj.onc.1204679;
RA   Yu W.-P., Pallen C.J., Tay A., Jirik F.R., Brenner S., Tan Y.-H.,
RA   Venkatesh B.;
RT   "Conserved synteny between the Fugu and human PTEN locus and the
RT   evolutionary conservation of vertebrate PTEN function.";
RL   Oncogene 20:5554-5561(2001).
CC   -!- FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-
CC       triphosphate receptor (ITPR) Ca(2+) release.
CC       {ECO:0000250|UniProtKB:Q8IWB1}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IWB1};
CC       Single-pass type I membrane protein {ECO:0000255}. Nucleus outer
CC       membrane {ECO:0000250|UniProtKB:Q3TNL8}; Single-pass type I membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ITPRIP family. {ECO:0000305}.
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DR   EMBL; AF325922; AAL08420.1; -; Genomic_DNA.
DR   RefSeq; XP_003964036.1; XM_003963987.2.
DR   AlphaFoldDB; Q90XY5; -.
DR   STRING; 31033.ENSTRUP00000024626; -.
DR   GeneID; 101067007; -.
DR   KEGG; tru:101067007; -.
DR   CTD; 85450; -.
DR   eggNOG; ENOG502QRDF; Eukaryota.
DR   InParanoid; Q90XY5; -.
DR   OrthoDB; 378719at2759; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005640; C:nuclear outer membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR024797; IP3R-int.
DR   InterPro; IPR026250; ITPRIP_fam.
DR   InterPro; IPR024810; Mab-21_dom.
DR   PANTHER; PTHR10656:SF8; PTHR10656:SF8; 1.
DR   Pfam; PF03281; Mab-21; 1.
DR   PRINTS; PR02107; INOS145TPRIP.
DR   SMART; SM01265; Mab-21; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Coiled coil; Glycoprotein; Membrane; Nucleus;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..534
FT                   /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT                   protein"
FT                   /id="PRO_0000320570"
FT   TOPO_DOM        16..74
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        92..534
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   COILED          25..63
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        27
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   534 AA;  60220 MW;  856963B078F88816 CRC64;
     MQGAIARMCV LVAAAILNHP LLSPQENATL HDQDEELMAR MREHEEMLEK EQAKLEKEFS
     QLTPEPENIG SEEEYSGYLW SSVVFLVFLV IEMFRMHGAH TEIAPFGDED IYSEGGSLAP
     RLKALDKEVL NNFCDKCTYT SSNEIWRVRE FVEGFADDLL ESLRSVCDRD ADMEVGDFVG
     IGSVFESWKV CKPLMCDLLV PFSPPDPFAL QFHLWCSCSS NVPPNMQGCG KIKVSKSGGN
     EGCLCGSANM GEDMLCLLHN GNDVPSVERS PDDLLCTRNT SFLSKDQVMK WFQISVTKAW
     GRISHKYDFE VTFRNLDAAG ALKVRFHSGK VVVLNMIPVV QLQDTDAYFV SHFPSGSESP
     PDPYWPLSFA VYERNLLKLI SKRLPQNSCH LHCLQIVTFL HRKQASLTGR TALTNYHIKT
     VLLHLLLGKR ASSWGTEHME SRLCDLLSFL HRSLQEKRLH HVMIGNSKVT ELIQVPEIIS
     RAEPVNLLRC LVLQAELHAQ TLQHFNEMLK NAPALLQDYT PHWSNGLCLL GDGV