APOL1_HUMAN
ID APOL1_HUMAN Reviewed; 398 AA.
AC O14791; A5PLQ4; B4DU12; E9PF24; O60804; Q5R3P7; Q5R3P8; Q96AB8; Q96PM4;
AC Q9BQ03;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 5.
DT 03-AUG-2022, entry version 185.
DE RecName: Full=Apolipoprotein L1;
DE AltName: Full=Apolipoprotein L;
DE Short=Apo-L;
DE Short=ApoL;
DE AltName: Full=Apolipoprotein L-I;
DE Short=ApoL-I;
DE Flags: Precursor;
GN Name=APOL1; Synonyms=APOL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 28-63, AND
RP VARIANTS LYS-150; ILE-228 AND LYS-255.
RC TISSUE=Pancreas;
RX PubMed=9325276; DOI=10.1074/jbc.272.41.25576;
RA Duchateau P.N., Pullinger C.R., Orellana R.E., Kunitake S.T.,
RA Naya-Vigne J., O'Connor P.M., Malloy M.J., Kane J.P.;
RT "Apolipoprotein L, a new human high density lipoprotein apolipoprotein
RT expressed by the pancreas. Identification, cloning, characterization, and
RT plasma distribution of apolipoprotein L.";
RL J. Biol. Chem. 272:25576-25582(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2),
RP SEQUENCE REVISION TO 155 AND 346, AND VARIANTS LYS-150; ILE-228 AND
RP LYS-255.
RC TISSUE=Pancreas;
RX PubMed=11290834;
RA Duchateau P.N., Pullinger C.R., Cho M.H., Eng C., Kane J.P.;
RT "Apolipoprotein L gene family: tissue-specific expression, splicing,
RT promoter regions; discovery of a new gene.";
RL J. Lipid Res. 42:620-630(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=11374903; DOI=10.1006/geno.2001.6534;
RA Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.;
RT "The human apolipoprotein L gene cluster: identification, classification,
RT and sites of distribution.";
RL Genomics 74:71-78(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ILE-228; LYS-255;
RP GLY-342 AND MET-384.
RX PubMed=11944986; DOI=10.1006/geno.2002.6729;
RA Monajemi H., Fontijn R.D., Pannekoek H., Horrevoets A.J.G.;
RT "The apolipoprotein L gene cluster has emerged recently in evolution and is
RT expressed in human vascular tissue.";
RL Genomics 79:539-546(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANTS LYS-150;
RP ILE-228 AND LYS-255.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261.
RC TISSUE=Plasma;
RX PubMed=16335952; DOI=10.1021/pr0502065;
RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J.,
RA Smith R.D.;
RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT hydrazide chemistry, and mass spectrometry.";
RL J. Proteome Res. 4:2070-2080(2005).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311 AND SER-314, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [10]
RP PHOSPHORYLATION AT SER-311 AND SER-314.
RX PubMed=26091039; DOI=10.1016/j.cell.2015.05.028;
RA Tagliabracci V.S., Wiley S.E., Guo X., Kinch L.N., Durrant E., Wen J.,
RA Xiao J., Cui J., Nguyen K.B., Engel J.L., Coon J.J., Grishin N.,
RA Pinna L.A., Pagliarini D.J., Dixon J.E.;
RT "A single kinase generates the majority of the secreted phosphoproteome.";
RL Cell 161:1619-1632(2015).
RN [11]
RP VARIANT [LARGE SCALE ANALYSIS] THR-188.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [12]
RP VARIANTS FSGS4 GLY-342 AND MET-384.
RX PubMed=20635188; DOI=10.1007/s00439-010-0861-0;
RA Tzur S., Rosset S., Shemer R., Yudkovsky G., Selig S., Tarekegn A.,
RA Bekele E., Bradman N., Wasser W.G., Behar D.M., Skorecki K.;
RT "Missense mutations in the APOL1 gene are highly associated with end stage
RT kidney disease risk previously attributed to the MYH9 gene.";
RL Hum. Genet. 128:345-350(2010).
RN [13]
RP VARIANTS FSGS4 GLY-342 AND MET-384.
RX PubMed=20647424; DOI=10.1126/science.1193032;
RA Genovese G., Friedman D.J., Ross M.D., Lecordier L., Uzureau P.,
RA Freedman B.I., Bowden D.W., Langefeld C.D., Oleksyk T.K.,
RA Uscinski Knob A.L., Bernhardy A.J., Hicks P.J., Nelson G.W.,
RA Vanhollebeke B., Winkler C.A., Kopp J.B., Pays E., Pollak M.R.;
RT "Association of trypanolytic ApoL1 variants with kidney disease in African
RT Americans.";
RL Science 329:841-845(2010).
CC -!- FUNCTION: May play a role in lipid exchange and transport throughout
CC the body. May participate in reverse cholesterol transport from
CC peripheral cells to the liver.
CC -!- SUBUNIT: In plasma, interacts with APOA1 and mainly associated with
CC large high density lipoprotein particles.
CC -!- INTERACTION:
CC O14791; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-1221934, EBI-396137;
CC O14791; Q8IXL6: FAM20C; NbExp=2; IntAct=EBI-1221934, EBI-7147442;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=A;
CC IsoId=O14791-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=O14791-2; Sequence=VSP_000292;
CC Name=3;
CC IsoId=O14791-3; Sequence=VSP_045077;
CC -!- TISSUE SPECIFICITY: Plasma. Found on APOA-I-containing high density
CC lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver,
CC placenta and spleen.
CC -!- PTM: Phosphorylated by FAM20C in the extracellular medium.
CC {ECO:0000269|PubMed:26091039}.
CC -!- DISEASE: Focal segmental glomerulosclerosis 4 (FSGS4) [MIM:612551]: A
CC renal pathology defined by the presence of segmental sclerosis in
CC glomeruli and resulting in proteinuria, reduced glomerular filtration
CC rate and progressive decline in renal function. Renal insufficiency
CC often progresses to end-stage renal disease, a highly morbid state
CC requiring either dialysis therapy or kidney transplantation.
CC {ECO:0000269|PubMed:20635188, ECO:0000269|PubMed:20647424}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- MISCELLANEOUS: [Isoform 1]: Major isoform.
CC -!- SIMILARITY: Belongs to the apolipoprotein L family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB81218.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF019225; AAB81218.2; ALT_INIT; mRNA.
DR EMBL; AF323540; AAG53690.1; -; mRNA.
DR EMBL; AF323548; AAK11591.1; -; Genomic_DNA.
DR EMBL; AF323543; AAK11591.1; JOINED; Genomic_DNA.
DR EMBL; AF323544; AAK11591.1; JOINED; Genomic_DNA.
DR EMBL; AF323545; AAK11591.1; JOINED; Genomic_DNA.
DR EMBL; AF323546; AAK11591.1; JOINED; Genomic_DNA.
DR EMBL; AF323547; AAK11591.1; JOINED; Genomic_DNA.
DR EMBL; AF305224; AAK20210.1; -; mRNA.
DR EMBL; AF305428; AAL09358.1; -; mRNA.
DR EMBL; AK300454; BAG62174.1; -; mRNA.
DR EMBL; Z82215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC143039; AAI43040.1; -; mRNA.
DR CCDS; CCDS13925.1; -. [O14791-2]
DR CCDS; CCDS13926.1; -. [O14791-1]
DR CCDS; CCDS46702.1; -. [O14791-3]
DR RefSeq; NP_001130012.1; NM_001136540.1. [O14791-1]
DR RefSeq; NP_001130013.1; NM_001136541.1. [O14791-3]
DR RefSeq; NP_003652.2; NM_003661.3. [O14791-1]
DR RefSeq; XP_005261853.1; XM_005261796.3.
DR PDB; 7L6K; NMR; -; A=61-172.
DR PDB; 7LF7; X-ray; 2.03 A; K/M=61-172.
DR PDB; 7LFA; X-ray; 1.86 A; A/C=61-172.
DR PDB; 7LFB; X-ray; 1.91 A; X=61-172.
DR PDB; 7LFD; X-ray; 2.16 A; A=152-168.
DR PDBsum; 7L6K; -.
DR PDBsum; 7LF7; -.
DR PDBsum; 7LFA; -.
DR PDBsum; 7LFB; -.
DR PDBsum; 7LFD; -.
DR AlphaFoldDB; O14791; -.
DR SMR; O14791; -.
DR BioGRID; 114112; 3.
DR CORUM; O14791; -.
DR IntAct; O14791; 3.
DR STRING; 9606.ENSP00000317674; -.
DR BindingDB; O14791; -.
DR ChEMBL; CHEMBL4680021; -.
DR DrugBank; DB11886; Infigratinib.
DR DrugBank; DB00877; Sirolimus.
DR DrugBank; DB01593; Zinc.
DR DrugBank; DB14487; Zinc acetate.
DR DrugBank; DB14533; Zinc chloride.
DR DrugBank; DB14548; Zinc sulfate, unspecified form.
DR TCDB; 1.C.127.1.1; the pore-forming trypanolytic apolipoprotein a1 factor (apol1) family.
DR GlyGen; O14791; 2 sites, 2 O-linked glycans (1 site).
DR iPTMnet; O14791; -.
DR PhosphoSitePlus; O14791; -.
DR BioMuta; APOL1; -.
DR CPTAC; non-CPTAC-2628; -.
DR jPOST; O14791; -.
DR MassIVE; O14791; -.
DR MaxQB; O14791; -.
DR PaxDb; O14791; -.
DR PeptideAtlas; O14791; -.
DR PRIDE; O14791; -.
DR ProteomicsDB; 20010; -.
DR ProteomicsDB; 48240; -. [O14791-1]
DR ProteomicsDB; 48241; -. [O14791-2]
DR Antibodypedia; 875; 460 antibodies from 36 providers.
DR DNASU; 8542; -.
DR Ensembl; ENST00000319136.8; ENSP00000317674.4; ENSG00000100342.21. [O14791-2]
DR Ensembl; ENST00000397278.8; ENSP00000380448.4; ENSG00000100342.21. [O14791-1]
DR Ensembl; ENST00000397279.8; ENSP00000380449.4; ENSG00000100342.21. [O14791-1]
DR Ensembl; ENST00000422706.5; ENSP00000411507.1; ENSG00000100342.21. [O14791-1]
DR Ensembl; ENST00000426053.5; ENSP00000388477.1; ENSG00000100342.21. [O14791-3]
DR GeneID; 8542; -.
DR KEGG; hsa:8542; -.
DR MANE-Select; ENST00000397278.8; ENSP00000380448.4; NM_003661.4; NP_003652.2.
DR UCSC; uc003ape.4; human. [O14791-1]
DR CTD; 8542; -.
DR DisGeNET; 8542; -.
DR GeneCards; APOL1; -.
DR HGNC; HGNC:618; APOL1.
DR HPA; ENSG00000100342; Tissue enhanced (liver).
DR MalaCards; APOL1; -.
DR MIM; 603743; gene.
DR MIM; 612551; phenotype.
DR neXtProt; NX_O14791; -.
DR OpenTargets; ENSG00000100342; -.
DR Orphanet; 656; Genetic steroid-resistant nephrotic syndrome.
DR PharmGKB; PA24904; -.
DR VEuPathDB; HostDB:ENSG00000100342; -.
DR eggNOG; ENOG502RZGU; Eukaryota.
DR GeneTree; ENSGT01030000234599; -.
DR HOGENOM; CLU_046288_1_0_1; -.
DR InParanoid; O14791; -.
DR PhylomeDB; O14791; -.
DR TreeFam; TF334681; -.
DR PathwayCommons; O14791; -.
DR Reactome; R-HSA-2168880; Scavenging of heme from plasma.
DR Reactome; R-HSA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-HSA-8957275; Post-translational protein phosphorylation.
DR SignaLink; O14791; -.
DR BioGRID-ORCS; 8542; 11 hits in 1077 CRISPR screens.
DR ChiTaRS; APOL1; human.
DR GeneWiki; APOL1; -.
DR GenomeRNAi; 8542; -.
DR Pharos; O14791; Tbio.
DR PRO; PR:O14791; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; O14791; protein.
DR Bgee; ENSG00000100342; Expressed in gall bladder and 177 other tissues.
DR ExpressionAtlas; O14791; baseline and differential.
DR Genevisible; O14791; HS.
DR GO; GO:0072562; C:blood microparticle; HDA:UniProtKB.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
DR GO; GO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL.
DR GO; GO:0031224; C:intrinsic component of membrane; IC:BHF-UCL.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
DR GO; GO:0005254; F:chloride channel activity; IDA:BHF-UCL.
DR GO; GO:0008289; F:lipid binding; IDA:BHF-UCL.
DR GO; GO:1902476; P:chloride transmembrane transport; IDA:BHF-UCL.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0051838; P:cytolysis by host of symbiont cells; IDA:BHF-UCL.
DR GO; GO:0045087; P:innate immune response; IDA:BHF-UCL.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR InterPro; IPR008405; ApoL.
DR PANTHER; PTHR14096; PTHR14096; 1.
DR Pfam; PF05461; ApoL; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cholesterol metabolism;
KW Direct protein sequencing; Disease variant; Glycoprotein; HDL;
KW Lipid metabolism; Lipid transport; Phosphoprotein; Reference proteome;
KW Secreted; Signal; Steroid metabolism; Sterol metabolism; Transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000269|PubMed:9325276"
FT CHAIN 28..398
FT /note="Apolipoprotein L1"
FT /id="PRO_0000002040"
FT REGION 35..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 311
FT /note="Phosphoserine; by FAM20C"
FT /evidence="ECO:0000269|PubMed:26091039,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 314
FT /note="Phosphoserine; by FAM20C"
FT /evidence="ECO:0000269|PubMed:26091039,
FT ECO:0007744|PubMed:24275569"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16335952"
FT VAR_SEQ 1
FT /note="M -> MRFKSHTVELRRPCSDM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11290834"
FT /id="VSP_000292"
FT VAR_SEQ 16..33
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045077"
FT VARIANT 150
FT /note="E -> K (in dbSNP:rs2239785)"
FT /evidence="ECO:0000269|PubMed:11290834,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:9325276"
FT /id="VAR_011383"
FT VARIANT 188
FT /note="I -> T (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036568"
FT VARIANT 228
FT /note="M -> I (in dbSNP:rs136175)"
FT /evidence="ECO:0000269|PubMed:11290834,
FT ECO:0000269|PubMed:11944986, ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:9325276"
FT /id="VAR_011384"
FT VARIANT 255
FT /note="R -> K (in dbSNP:rs136176)"
FT /evidence="ECO:0000269|PubMed:11290834,
FT ECO:0000269|PubMed:11944986, ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:9325276"
FT /id="VAR_011385"
FT VARIANT 337
FT /note="D -> N (in dbSNP:rs16996616)"
FT /id="VAR_046641"
FT VARIANT 342
FT /note="S -> G (in FSGS4; dbSNP:rs73885319)"
FT /evidence="ECO:0000269|PubMed:11944986,
FT ECO:0000269|PubMed:20635188, ECO:0000269|PubMed:20647424"
FT /id="VAR_063598"
FT VARIANT 384
FT /note="I -> M (in FSGS4; dbSNP:rs60910145)"
FT /evidence="ECO:0000269|PubMed:11944986,
FT ECO:0000269|PubMed:20635188, ECO:0000269|PubMed:20647424"
FT /id="VAR_061995"
FT CONFLICT 24
FT /note="G -> R (in Ref. 1; AAG53690 and 2; AAK11591)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="E -> G (in Ref. 3; AAK20210)"
FT /evidence="ECO:0000305"
FT CONFLICT 346
FT /note="V -> A (in Ref. 3; AAK20210)"
FT /evidence="ECO:0000305"
FT HELIX 67..75
FT /evidence="ECO:0007829|PDB:7LFA"
FT HELIX 81..89
FT /evidence="ECO:0007829|PDB:7LFA"
FT HELIX 91..100
FT /evidence="ECO:0007829|PDB:7LFA"
FT HELIX 105..125
FT /evidence="ECO:0007829|PDB:7LFA"
FT HELIX 127..129
FT /evidence="ECO:0007829|PDB:7LFA"
FT STRAND 130..132
FT /evidence="ECO:0007829|PDB:7L6K"
FT HELIX 134..158
FT /evidence="ECO:0007829|PDB:7LFA"
FT HELIX 162..167
FT /evidence="ECO:0007829|PDB:7LFA"
SQ SEQUENCE 398 AA; 43974 MW; BD1A8F1D7C5A889F CRC64;
MEGAALLRVS VLCIWMSALF LGVGVRAEEA GARVQQNVPS GTDTGDPQSK PLGDWAAGTM
DPESSIFIED AIKYFKEKVS TQNLLLLLTD NEAWNGFVAA AELPRNEADE LRKALDNLAR
QMIMKDKNWH DKGQQYRNWF LKEFPRLKSE LEDNIRRLRA LADGVQKVHK GTTIANVVSG
SLSISSGILT LVGMGLAPFT EGGSLVLLEP GMELGITAAL TGITSSTMDY GKKWWTQAQA
HDLVIKSLDK LKEVREFLGE NISNFLSLAG NTYQLTRGIG KDIRALRRAR ANLQSVPHAS
ASRPRVTEPI SAESGEQVER VNEPSILEMS RGVKLTDVAP VSFFLVLDVV YLVYESKHLH
EGAKSETAEE LKKVAQELEE KLNILNNNYK ILQADQEL
