APOL5_HUMAN
ID APOL5_HUMAN Reviewed; 433 AA.
AC Q9BWW9; Q5TFL9; Q9UGW5;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Apolipoprotein L5;
DE AltName: Full=Apolipoprotein L-V;
DE Short=ApoL-V;
GN Name=APOL5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=11374903; DOI=10.1006/geno.2001.6534;
RA Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.;
RT "The human apolipoprotein L gene cluster: identification, classification,
RT and sites of distribution.";
RL Genomics 74:71-78(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
CC -!- FUNCTION: May affect the movement of lipids in the cytoplasm or allow
CC the binding of lipids to organelles.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Low level of expression; detected in uterus,
CC testis, skeletal muscle and stomach.
CC -!- SIMILARITY: Belongs to the apolipoprotein L family. {ECO:0000305}.
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DR EMBL; AY014878; AAK07723.1; -; mRNA.
DR EMBL; AL049748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS13920.1; -.
DR RefSeq; NP_085145.1; NM_030642.1.
DR AlphaFoldDB; Q9BWW9; -.
DR SMR; Q9BWW9; -.
DR BioGRID; 123324; 14.
DR IntAct; Q9BWW9; 7.
DR STRING; 9606.ENSP00000249044; -.
DR iPTMnet; Q9BWW9; -.
DR PhosphoSitePlus; Q9BWW9; -.
DR BioMuta; APOL5; -.
DR DMDM; 17433287; -.
DR PaxDb; Q9BWW9; -.
DR PeptideAtlas; Q9BWW9; -.
DR PRIDE; Q9BWW9; -.
DR ProteomicsDB; 79336; -.
DR TopDownProteomics; Q9BWW9; -.
DR Antibodypedia; 25462; 143 antibodies from 30 providers.
DR DNASU; 80831; -.
DR Ensembl; ENST00000249044.2; ENSP00000249044.2; ENSG00000128313.2.
DR GeneID; 80831; -.
DR KEGG; hsa:80831; -.
DR MANE-Select; ENST00000249044.2; ENSP00000249044.2; NM_030642.1; NP_085145.1.
DR UCSC; uc003aof.4; human.
DR CTD; 80831; -.
DR DisGeNET; 80831; -.
DR GeneCards; APOL5; -.
DR HGNC; HGNC:14869; APOL5.
DR HPA; ENSG00000128313; Tissue enhanced (skeletal muscle, tongue).
DR MIM; 607255; gene.
DR neXtProt; NX_Q9BWW9; -.
DR OpenTargets; ENSG00000128313; -.
DR PharmGKB; PA24908; -.
DR VEuPathDB; HostDB:ENSG00000128313; -.
DR eggNOG; ENOG502T3KK; Eukaryota.
DR GeneTree; ENSGT01030000234599; -.
DR HOGENOM; CLU_046288_0_1_1; -.
DR InParanoid; Q9BWW9; -.
DR OMA; HIPFWRA; -.
DR OrthoDB; 1077462at2759; -.
DR PhylomeDB; Q9BWW9; -.
DR TreeFam; TF334681; -.
DR PathwayCommons; Q9BWW9; -.
DR SignaLink; Q9BWW9; -.
DR BioGRID-ORCS; 80831; 16 hits in 1066 CRISPR screens.
DR GenomeRNAi; 80831; -.
DR Pharos; Q9BWW9; Tdark.
DR PRO; PR:Q9BWW9; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9BWW9; protein.
DR Bgee; ENSG00000128313; Expressed in hindlimb stylopod muscle and 23 other tissues.
DR Genevisible; Q9BWW9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0008035; F:high-density lipoprotein particle binding; NAS:UniProtKB.
DR GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; NAS:UniProtKB.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR InterPro; IPR008405; ApoL.
DR PANTHER; PTHR14096; PTHR14096; 1.
DR Pfam; PF05461; ApoL; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lipid transport; Reference proteome; Transport.
FT CHAIN 1..433
FT /note="Apolipoprotein L5"
FT /id="PRO_0000137603"
FT REGION 346..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 81
FT /note="E -> K (in dbSNP:rs5999985)"
FT /id="VAR_053012"
FT VARIANT 272
FT /note="T -> M (in dbSNP:rs2076671)"
FT /id="VAR_020355"
FT VARIANT 323
FT /note="T -> M (in dbSNP:rs2076672)"
FT /id="VAR_020356"
FT VARIANT 406
FT /note="S -> C (in dbSNP:rs2076673)"
FT /id="VAR_020357"
SQ SEQUENCE 433 AA; 47044 MW; F64416DE8FEB7E9E CRC64;
MPCGKQGNLQ VPGSKVLPGL GEGCKEMWLR KVIYGGEVWG KSPEPEFPSL VNLCQSWKIN
NLMSTVHSDE AGMLSYFLFE ELMRCDKDSM PDGNLSEEEK LFLSYFPLHK FELEQNIKEL
NTLADQVDTT HELLTKTSLV ASSSGAVSGV MNILGLALAP VTAGGSLMLS ATGTGLGAAA
AITNIVTNVL ENRSNSAARD KASRLGPLTT SHEAFGGINW SEIEAAGFCV NKCVKAIQGI
KDLHAYQMAK SNSGFMAMVK NFVAKRHIPF WTARGVQRAF EGTTLAMTNG AWVMGAAGAG
FLLMKDMSSF LQSWKHLEDG ARTETAEELR ALAKKLEQEL DRLTQHHRHL PQKASQTCSS
SRGRAVRGSR VVKPEGSRSP LPWPVVEHQP RLGPGVALRT PKRTVSAPRM LGHQPAPPAP
ARKGRQAPGR HRQ
