ID   APOL6_HUMAN             Reviewed;         343 AA.
AC   Q9BWW8; Q5R3S1; Q658J1; Q8IXX6; Q9UGG1;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Apolipoprotein L6;
DE   AltName: Full=Apolipoprotein L-VI;
DE            Short=ApoL-VI;
GN   Name=APOL6; ORFNames=UNQ3095/PRO21341;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=11374903; DOI=10.1006/geno.2001.6534;
RA   Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.;
RT   "The human apolipoprotein L gene cluster: identification, classification,
RT   and sites of distribution.";
RL   Genomics 74:71-78(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA   Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA   Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA   Beare D.M., Dunham I.;
RT   "A genome annotation-driven approach to cloning the human ORFeome.";
RL   Genome Biol. 5:R84.1-R84.11(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-173.
RC   TISSUE=Lymph node;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lymph;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May affect the movement of lipids in the cytoplasm or allow
CC       the binding of lipids to organelles.
CC   -!- INTERACTION:
CC       Q9BWW8; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11574440, EBI-10173507;
CC       Q9BWW8; P48745: CCN3; NbExp=3; IntAct=EBI-11574440, EBI-3904822;
CC       Q9BWW8; P49356: FNTB; NbExp=3; IntAct=EBI-11574440, EBI-602349;
CC       Q9BWW8; Q96IK5: GMCL1; NbExp=3; IntAct=EBI-11574440, EBI-2548508;
CC       Q9BWW8; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11574440, EBI-10171774;
CC       Q9BWW8; Q9UHA4: LAMTOR3; NbExp=3; IntAct=EBI-11574440, EBI-1038192;
CC       Q9BWW8; O14921: RGS13; NbExp=3; IntAct=EBI-11574440, EBI-17843660;
CC       Q9BWW8; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-11574440, EBI-11139477;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Widely expressed; highly expressed in the uterus,
CC       fetal brain and spinal cord, also detected in heart, liver, lung,
CC       colon, spleen, thymus, prostate, placenta, adrenal gland, salivary and
CC       mammary gland.
CC   -!- SIMILARITY: Belongs to the apolipoprotein L family. {ECO:0000305}.
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DR   EMBL; AY014879; AAK07724.1; -; mRNA.
DR   EMBL; AY358210; AAQ88577.1; -; mRNA.
DR   EMBL; CR456381; CAG30267.1; -; mRNA.
DR   EMBL; AL834420; CAH56356.1; -; mRNA.
DR   EMBL; Z79996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC038950; AAH38950.2; -; mRNA.
DR   EMBL; BC047864; AAH47864.1; -; mRNA.
DR   CCDS; CCDS13919.1; -.
DR   RefSeq; NP_085144.1; NM_030641.3.
DR   RefSeq; XP_011528694.1; XM_011530392.2.
DR   AlphaFoldDB; Q9BWW8; -.
DR   SMR; Q9BWW8; -.
DR   BioGRID; 123323; 14.
DR   IntAct; Q9BWW8; 10.
DR   STRING; 9606.ENSP00000386280; -.
DR   iPTMnet; Q9BWW8; -.
DR   PhosphoSitePlus; Q9BWW8; -.
DR   BioMuta; APOL6; -.
DR   DMDM; 17433286; -.
DR   EPD; Q9BWW8; -.
DR   jPOST; Q9BWW8; -.
DR   MassIVE; Q9BWW8; -.
DR   PaxDb; Q9BWW8; -.
DR   PeptideAtlas; Q9BWW8; -.
DR   PRIDE; Q9BWW8; -.
DR   ProteomicsDB; 79335; -.
DR   Antibodypedia; 25455; 264 antibodies from 30 providers.
DR   DNASU; 80830; -.
DR   Ensembl; ENST00000409652.5; ENSP00000386280.3; ENSG00000221963.6.
DR   GeneID; 80830; -.
DR   KEGG; hsa:80830; -.
DR   MANE-Select; ENST00000409652.5; ENSP00000386280.3; NM_030641.4; NP_085144.1.
DR   UCSC; uc003aoe.4; human.
DR   CTD; 80830; -.
DR   DisGeNET; 80830; -.
DR   GeneCards; APOL6; -.
DR   HGNC; HGNC:14870; APOL6.
DR   HPA; ENSG00000221963; Tissue enhanced (liver).
DR   MIM; 607256; gene.
DR   neXtProt; NX_Q9BWW8; -.
DR   OpenTargets; ENSG00000221963; -.
DR   PharmGKB; PA24909; -.
DR   VEuPathDB; HostDB:ENSG00000221963; -.
DR   eggNOG; ENOG502QPNS; Eukaryota.
DR   GeneTree; ENSGT01030000234599; -.
DR   HOGENOM; CLU_046288_0_1_1; -.
DR   InParanoid; Q9BWW8; -.
DR   OMA; CETEAYW; -.
DR   OrthoDB; 1363478at2759; -.
DR   PhylomeDB; Q9BWW8; -.
DR   TreeFam; TF334681; -.
DR   PathwayCommons; Q9BWW8; -.
DR   SignaLink; Q9BWW8; -.
DR   BioGRID-ORCS; 80830; 14 hits in 1079 CRISPR screens.
DR   ChiTaRS; APOL6; human.
DR   GeneWiki; APOL6; -.
DR   GenomeRNAi; 80830; -.
DR   Pharos; Q9BWW8; Tbio.
DR   PRO; PR:Q9BWW8; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; Q9BWW8; protein.
DR   Bgee; ENSG00000221963; Expressed in pericardium and 179 other tissues.
DR   ExpressionAtlas; Q9BWW8; baseline and differential.
DR   Genevisible; Q9BWW8; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   InterPro; IPR008405; ApoL.
DR   PANTHER; PTHR14096; PTHR14096; 1.
DR   Pfam; PF05461; ApoL; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Lipid transport; Reference proteome; Transport.
FT   CHAIN           1..343
FT                   /note="Apolipoprotein L6"
FT                   /id="PRO_0000137604"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         173
FT                   /note="N -> K (in dbSNP:rs5999923)"
FT                   /evidence="ECO:0000269|PubMed:17974005"
FT                   /id="VAR_053013"
SQ   SEQUENCE   343 AA;  38128 MW;  9101D15ABAE71CDE CRC64;
     MDNQAERESE AGVGLQRDED DAPLCEDVEL QDGDLSPEEK IFLREFPRLK EDLKGNIDKL
     RALADDIDKT HKKFTKANMV ATSTAVISGV MSLLGLALAP ATGGGSLLLS TAGQGLATAA
     GVTSIVSGTL ERSKNKEAQA RAEDILPTYD QEDREDEEEK ADYVTAAGKI IYNLRNTLKY
     AKKNVRAFWK LRANPRLANA TKRLLTTGQV SSRSRVQVQK AFAGTTLAMT KNARVLGGVM
     SAFSLGYDLA TLSKEWKHLK EGARTKFAEE LRAKALELER KLTELTQLYK SLQQKVRSRA
     RGVGKDLTGT CETEAYWKEL REHVWMWLWL CVCLCVCVYV QFT