ID   APOM_PIG                Reviewed;         188 AA.
AC   Q2LE37;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Apolipoprotein M;
DE            Short=Apo-M;
DE            Short=ApoM;
GN   Name=APOM;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Pan G., Xiong Y.Z.;
RT   "Isolation, identification of the swine apolipoprotein M gene.";
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RA   Pan G., Xiong Y.Z.;
RT   "The swine apolipoprotein M gene isolated from liver cDNA.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Porcine genome sequencing project;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in lipid transport. Can bind sphingosine-1-
CC       phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-
CC       trans-retinoic acid and 9-cis-retinoic acid (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with LRP2; LRP2 mediates APOM renal uptake and
CC       subsequent lysosomal degradation. {ECO:0000250|UniProtKB:Q9Z1R3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       Highly divergent. {ECO:0000305}.
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DR   EMBL; DQ329240; ABC59064.1; -; mRNA.
DR   EMBL; DQ272488; ABB85067.1; -; Genomic_DNA.
DR   EMBL; BX548169; CAN59667.1; -; Genomic_DNA.
DR   RefSeq; NP_001035730.1; NM_001040640.1.
DR   AlphaFoldDB; Q2LE37; -.
DR   SMR; Q2LE37; -.
DR   STRING; 9823.ENSSSCP00000001505; -.
DR   PaxDb; Q2LE37; -.
DR   PeptideAtlas; Q2LE37; -.
DR   PRIDE; Q2LE37; -.
DR   Ensembl; ENSSSCT00000001547; ENSSSCP00000001505; ENSSSCG00000001411.
DR   Ensembl; ENSSSCT00005057356; ENSSSCP00005035313; ENSSSCG00005035650.
DR   Ensembl; ENSSSCT00015107654; ENSSSCP00015045507; ENSSSCG00015079344.
DR   Ensembl; ENSSSCT00015107805; ENSSSCP00015045617; ENSSSCG00015079344.
DR   Ensembl; ENSSSCT00025108177; ENSSSCP00025048961; ENSSSCG00025077716.
DR   Ensembl; ENSSSCT00030085765; ENSSSCP00030039549; ENSSSCG00030061308.
DR   Ensembl; ENSSSCT00035022041; ENSSSCP00035008051; ENSSSCG00035017168.
DR   Ensembl; ENSSSCT00040093813; ENSSSCP00040041427; ENSSSCG00040068399.
DR   Ensembl; ENSSSCT00045064247; ENSSSCP00045045368; ENSSSCG00045037175.
DR   Ensembl; ENSSSCT00050010572; ENSSSCP00050004542; ENSSSCG00050007721.
DR   Ensembl; ENSSSCT00055055816; ENSSSCP00055044558; ENSSSCG00055028122.
DR   Ensembl; ENSSSCT00060071322; ENSSSCP00060030783; ENSSSCG00060052387.
DR   Ensembl; ENSSSCT00065050216; ENSSSCP00065021739; ENSSSCG00065036803.
DR   Ensembl; ENSSSCT00070047620; ENSSSCP00070040188; ENSSSCG00070023864.
DR   GeneID; 692188; -.
DR   KEGG; ssc:692188; -.
DR   CTD; 55937; -.
DR   VGNC; VGNC:85424; APOM.
DR   eggNOG; ENOG502S2IN; Eukaryota.
DR   GeneTree; ENSGT00390000001026; -.
DR   HOGENOM; CLU_105274_0_0_1; -.
DR   InParanoid; Q2LE37; -.
DR   OrthoDB; 1302737at2759; -.
DR   TreeFam; TF330771; -.
DR   Reactome; R-SSC-975634; Retinoid metabolism and transport.
DR   Proteomes; UP000008227; Chromosome 7.
DR   Proteomes; UP000314985; Chromosome 7.
DR   Bgee; ENSSSCG00000001411; Expressed in right lobe of liver and 43 other tissues.
DR   ExpressionAtlas; Q2LE37; baseline and differential.
DR   Genevisible; Q2LE37; SS.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0034362; C:low-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR   GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR   GO; GO:0033344; P:cholesterol efflux; IBA:GO_Central.
DR   GO; GO:0034380; P:high-density lipoprotein particle assembly; IBA:GO_Central.
DR   GO; GO:0034384; P:high-density lipoprotein particle clearance; IBA:GO_Central.
DR   GO; GO:0034375; P:high-density lipoprotein particle remodeling; IBA:GO_Central.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR022734; ApoM.
DR   InterPro; IPR012674; Calycin.
DR   PANTHER; PTHR32028; PTHR32028; 1.
DR   Pfam; PF11032; ApoM; 1.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; HDL; Lipid transport; Reference proteome; Secreted; Signal;
KW   Transport.
FT   CHAIN           1..188
FT                   /note="Apolipoprotein M"
FT                   /id="PRO_0000296390"
FT   SIGNAL          1..?22
FT                   /note="Not cleaved"
FT                   /evidence="ECO:0000250"
FT   BINDING         136
FT                   /ligand="tetradecanoate"
FT                   /ligand_id="ChEBI:CHEBI:30807"
FT                   /evidence="ECO:0000250|UniProtKB:O95445"
FT   BINDING         143
FT                   /ligand="tetradecanoate"
FT                   /ligand_id="ChEBI:CHEBI:30807"
FT                   /evidence="ECO:0000250|UniProtKB:O95445"
FT   DISULFID        23..167
FT                   /evidence="ECO:0000250"
FT   DISULFID        95..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        128..157
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   188 AA;  21241 MW;  82F96E45A02716DA CRC64;
     MFHQIWAALL YLYGILLNSI YQCPEHSQLT TGGVDGKEFP EPHLGQWYFI AGAAPTKEEL
     ATFDPVDNIV FNMAAGSVPM QLQLRATIRT KNGLCVPRKW IYRLSEGNTD LRTEGRPDMK
     TKLFSSTCPG GIMLKETGQG YQRFLLYNRS PHPPEKCVEE FQSLTSCLDF KAFLLTPRNQ
     EACELSSN