ID   APOR_PIG                Reviewed;         202 AA.
AC   Q03472;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Apolipoprotein R;
DE            Short=Apo-R;
DE   Flags: Precursor;
GN   Name=APOR;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 29-47.
RC   TISSUE=Liver;
RX   PubMed=1463721; DOI=10.1021/bi00164a006;
RA   Cooper S.T., Attie A.D.;
RT   "Pig apolipoprotein R: a new member of the short consensus repeat family of
RT   proteins.";
RL   Biochemistry 31:12328-12336(1992).
CC   -!- FUNCTION: May be a lipoprotein-borne regulator of either the
CC       coagulation or the complement cascades.
CC   -!- SUBUNIT: Forms high molecular weight disulfide-linked complexes.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Plasma. Found on very low-density lipoprotein
CC       (VLDL), on chylomicrons, and in the D > 1.21 g/ml fraction of pig
CC       plasma. Found in liver, spleen, lung, bone marrow and lymph node.
CC   -!- DEVELOPMENTAL STAGE: Terminally differentiated macrophages.
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DR   EMBL; L06820; AAA30994.1; -; mRNA.
DR   PIR; A44247; A44247.
DR   RefSeq; NP_999107.1; NM_213942.1.
DR   AlphaFoldDB; Q03472; -.
DR   SMR; Q03472; -.
DR   STRING; 9823.ENSSSCP00000016606; -.
DR   PaxDb; Q03472; -.
DR   PeptideAtlas; Q03472; -.
DR   GeneID; 396982; -.
DR   KEGG; ssc:396982; -.
DR   CTD; 722; -.
DR   eggNOG; ENOG502RWWT; Eukaryota.
DR   InParanoid; Q03472; -.
DR   OrthoDB; 1212292at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0045959; P:negative regulation of complement activation, classical pathway; IBA:GO_Central.
DR   CDD; cd00033; CCP; 2.
DR   InterPro; IPR040514; C4bp_oligo.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF18453; C4bp_oligo; 1.
DR   Pfam; PF00084; Sushi; 2.
DR   SMART; SM00032; CCP; 2.
DR   SUPFAM; SSF57535; SSF57535; 2.
DR   PROSITE; PS50923; SUSHI; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Lipid transport;
KW   Reference proteome; Repeat; Secreted; Signal; Sushi; Transport.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000269|PubMed:1463721"
FT   CHAIN           29..202
FT                   /note="Apolipoprotein R"
FT                   /id="PRO_0000002063"
FT   DOMAIN          29..87
FT                   /note="Sushi 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DOMAIN          88..145
FT                   /note="Sushi 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        30..73
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        59..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        89..130
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        116..143
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        151
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   DISULFID        163
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   CONFLICT        44
FT                   /note="I -> V (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        46
FT                   /note="G -> A (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   202 AA;  22724 MW;  EABC951B06A0D80C CRC64;
     MPPNLQRIFP ALCLLGVLFL LHCTPVLCGC DNPPVVAHGH HTQIIGLFGM KKDEVVYKCD
     EGYTLVGEDR LSCRSSRWSP AAPQCKALCP KPQIDRGKLS VDQDEYIESE NVIVQCGSGY
     GLVGPKIITC TEDGTWHPRV PKCEWEYPED CEQVHEGKKL MQCLPNLEEI KLALELYKLS
     LETKLLELQI DKEKKAKAKY SI