APOV1_CHICK
ID APOV1_CHICK Reviewed; 106 AA.
AC P02659; Q90882;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Apovitellenin-1;
DE AltName: Full=Apo-VLDL-II;
DE Short=Apo-II;
DE AltName: Full=Apovitellenin I;
DE AltName: Full=Very low density lipoprotein II;
DE Flags: Precursor;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6856469; DOI=10.1093/nar/11.9.2529;
RA van Het Schip A.D., Meijlink F.C.P.W., Strijker R., Gruber M.,
RA van Vliet A.J., van de Klundert J.A.M., Ab G.;
RT "The nucleotide sequence of the chicken apo very low density lipoprotein II
RT gene.";
RL Nucleic Acids Res. 11:2529-2540(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7012793; DOI=10.1093/nar/9.3.489;
RA Wieringa B., Ab G., Gruber M.;
RT "The nucleotide sequence of the very low density lipoprotein II mRNA from
RT chicken.";
RL Nucleic Acids Res. 9:489-501(1981).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=7286648; DOI=10.1016/0378-1119(81)90113-x;
RA Dugaiczyk A., Inglis A.S., Strike P.M., Burley R.W., Beattie W.G., Chan L.;
RT "Comparison of the nucleotide sequence of cloned DNA coding for an
RT apolipoprotein (apo VLDL-II) from avian blood and the amino acid sequence
RT of an egg-yolk protein (apovitellenin I): equivalence of the two
RT sequences.";
RL Gene 14:175-182(1981).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2703502; DOI=10.1016/s0021-9258(18)83375-0;
RA Cochrane A., Deeley R.G.;
RT "Detection and characterization of degradative intermediates of avian apo
RT very low density lipoprotein II mRNA present in estrogen-treated birds and
RT following destabilization by hormone withdrawal.";
RL J. Biol. Chem. 264:6495-6503(1989).
RN [5]
RP PROTEIN SEQUENCE OF 1-51 (PRECURSOR PROTEIN).
RX PubMed=7430115; DOI=10.1016/s0021-9258(19)70427-x;
RA Chan L., Bradley W.A., Means A.R.;
RT "Amino acid sequence of the signal peptide of apoVLDL-II, a major
RT apoprotein in avian very low density lipoproteins.";
RL J. Biol. Chem. 255:10060-10063(1980).
RN [6]
RP PROTEIN SEQUENCE OF 25-106.
RC TISSUE=Egg yolk;
RX PubMed=988817; DOI=10.1071/bi9760175;
RA Dopheide T.A.A., Inglis A.S.;
RT "Primary structure of apovitellenin I from hen egg yolk and its comparison
RT with emu apovitellenin I.";
RL Aust. J. Biol. Sci. 29:175-180(1976).
RN [7]
RP PROTEIN SEQUENCE OF 25-106.
RC TISSUE=Plasma;
RX PubMed=188805; DOI=10.1016/s0021-9258(17)32824-7;
RA Jackson R.L., Lin H.-Y., Chan L., Means A.R.;
RT "Amino acid sequence of a major apoprotein from hen plasma very low density
RT lipoproteins.";
RL J. Biol. Chem. 252:250-253(1977).
CC -!- FUNCTION: Protein component of the very low density lipoprotein (VLDL)
CC of egg-laying females. Potent lipoprotein lipase inhibitor, preventing
CC the loss of triglycerides from VLDL on their way from the liver to the
CC growing oocytes.
CC -!- SUBUNIT: Homodimer; disulfide-linked.
CC -!- TISSUE SPECIFICITY: Produced by the liver, secreted into the blood and
CC then sequestred by receptor mediated endocytosis into growing oocytes.
CC -!- DEVELOPMENTAL STAGE: ApoII mRNA induction by estrogen in kidney at day
CC 11 is at 10% of the level in the liver but estrogen-responsiveness
CC decreases later in development and is low in the adult.
CC -!- INDUCTION: By steroids (estrogen).
CC -!- SIMILARITY: Belongs to the apovitellenin family. {ECO:0000305}.
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DR EMBL; V00449; CAA23727.1; -; mRNA.
DR EMBL; J00810; AAA48596.1; -; Genomic_DNA.
DR EMBL; M25774; AAA48938.1; -; mRNA.
DR PIR; A93464; VLCH1.
DR PIR; I50374; I50374.
DR RefSeq; NP_990814.2; NM_205483.2.
DR RefSeq; XP_015151420.1; XM_015295934.1.
DR AlphaFoldDB; P02659; -.
DR SMR; P02659; -.
DR STRING; 9031.ENSGALP00000024373; -.
DR Allergome; 2740; Gal d Apo I.
DR PaxDb; P02659; -.
DR Ensembl; ENSGALT00000024419; ENSGALP00000024373; ENSGALG00000015134.
DR GeneID; 396476; -.
DR KEGG; gga:396476; -.
DR CTD; 396476; -.
DR VEuPathDB; HostDB:geneid_396476; -.
DR eggNOG; ENOG502SRWC; Eukaryota.
DR GeneTree; ENSGT00530000066877; -.
DR HOGENOM; CLU_176392_0_0_1; -.
DR InParanoid; P02659; -.
DR OMA; RRDWLVI; -.
DR OrthoDB; 1497857at2759; -.
DR PhylomeDB; P02659; -.
DR PRO; PR:P02659; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000015134; Expressed in liver and 4 other tissues.
DR GO; GO:0042627; C:chylomicron; IEA:InterPro.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0004857; F:enzyme inhibitor activity; IEA:InterPro.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR InterPro; IPR008404; Apo-VLDL-II.
DR Pfam; PF05418; Apo-VLDL-II; 1.
DR PIRSF; PIRSF002369; Apo-VLDL-II; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Reference proteome; Signal;
KW Storage protein; VLDL.
FT SIGNAL 1..24
FT /evidence="ECO:0000269|PubMed:188805,
FT ECO:0000269|PubMed:7012793, ECO:0000269|PubMed:988817"
FT CHAIN 25..106
FT /note="Apovitellenin-1"
FT /id="PRO_0000002064"
FT DISULFID 99
FT /note="Interchain"
FT /evidence="ECO:0000269|PubMed:188805"
FT CONFLICT 2
FT /note="Missing (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 23
FT /note="H -> C (in Ref. 5; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 68..69
FT /note="TV -> NS (in Ref. 4; AAA48938)"
FT /evidence="ECO:0000305"
FT CONFLICT 71..73
FT /note="SGI -> IGS (in Ref. 6; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 91..92
FT /note="LM -> ML (in Ref. 6; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 106 AA; 11966 MW; 8A17DA72F574AF67 CRC64;
MVQYRALVIA VILLLSTTVP EVHSKSIIDR ERRDWLVIPD AAAAYIYEAV NKVSPRAGQF
LLDVSQTTVV SGIRNFLINE TARLTKLAEQ LMEKIKNLCY TKVLGY
