ID   APOV1_COTJA             Reviewed;         105 AA.
AC   P79886;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Apovitellenin-1;
DE   AltName: Full=Apo-VLDL-II;
DE            Short=Apo-II;
DE   AltName: Full=Apovitellenin I;
DE   AltName: Full=Very low density lipoprotein II;
DE   Flags: Precursor;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=8713091; DOI=10.1042/bj3170599;
RA   Maclachlan I., Steyrer E., Hermetter A., Nimpf J., Schneider W.J.;
RT   "Molecular characterization of quail apolipoprotein very-low-density
RT   lipoprotein II: disulphide-bond-mediated dimerization is not essential for
RT   inhibition of lipoprotein lipase.";
RL   Biochem. J. 317:599-604(1996).
CC   -!- FUNCTION: Protein component of the very low density lipoprotein (VLDL)
CC       of egg-laying females. Potent lipoprotein lipase inhibitor, preventing
CC       the loss of triglycerides from VLDL on their way from the liver to the
CC       growing oocytes.
CC   -!- SUBUNIT: Monomer.
CC   -!- TISSUE SPECIFICITY: Produced by the liver, secreted into the blood and
CC       then sequestred by receptor mediated endocytosis into growing oocytes.
CC   -!- INDUCTION: By steroids (estrogen).
CC   -!- SIMILARITY: Belongs to the apovitellenin family. {ECO:0000305}.
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DR   EMBL; S82591; AAB37468.1; -; mRNA.
DR   AlphaFoldDB; P79886; -.
DR   SMR; P79886; -.
DR   Proteomes; UP000694412; Unplaced.
DR   GO; GO:0042627; C:chylomicron; IEA:InterPro.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0004857; F:enzyme inhibitor activity; IEA:InterPro.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   InterPro; IPR008404; Apo-VLDL-II.
DR   Pfam; PF05418; Apo-VLDL-II; 1.
DR   PIRSF; PIRSF002369; Apo-VLDL-II; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Signal; Storage protein; VLDL.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..105
FT                   /note="Apovitellenin-1"
FT                   /id="PRO_0000002065"
SQ   SEQUENCE   105 AA;  11940 MW;  41E8633872EA4EB2 CRC64;
     MVQYRELVIA LILLLSTTVP EVHSRSLSDR GRRDWMVYPD ALASYIYEAV NTVSPRAAQF
     LLDVSQTTVV SGARNLLIRE TTKITILVEQ MVEKIRSIWN GKLGY