APP1_SCHPO
ID APP1_SCHPO Reviewed; 857 AA.
AC Q9P7E8; P78815;
DT 30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Protein app1;
GN Name=app1; ORFNames=SPAPJ760.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 560-857.
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
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DR EMBL; CU329670; CAB83085.1; -; Genomic_DNA.
DR EMBL; D89164; BAA13826.1; ALT_SEQ; mRNA.
DR PIR; T42526; T42526.
DR RefSeq; NP_594921.1; NM_001020353.2.
DR AlphaFoldDB; Q9P7E8; -.
DR SMR; Q9P7E8; -.
DR BioGRID; 279417; 6.
DR STRING; 4896.SPAPJ760.02c.1; -.
DR iPTMnet; Q9P7E8; -.
DR MaxQB; Q9P7E8; -.
DR PaxDb; Q9P7E8; -.
DR PRIDE; Q9P7E8; -.
DR EnsemblFungi; SPAPJ760.02c.1; SPAPJ760.02c.1:pep; SPAPJ760.02c.
DR GeneID; 2542979; -.
DR KEGG; spo:SPAPJ760.02c; -.
DR PomBase; SPAPJ760.02c; -.
DR VEuPathDB; FungiDB:SPAPJ760.02c; -.
DR eggNOG; KOG3655; Eukaryota.
DR HOGENOM; CLU_013085_2_0_1; -.
DR InParanoid; Q9P7E8; -.
DR OMA; HIPAIRN; -.
DR Reactome; R-SPO-6798695; Neutrophil degranulation.
DR Reactome; R-SPO-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-SPO-9013405; RHOD GTPase cycle.
DR PRO; PR:Q9P7E8; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0099079; C:actin body; IDA:PomBase.
DR GO; GO:0030479; C:actin cortical patch; IDA:PomBase.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030427; C:site of polarized growth; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IBA:GO_Central.
DR CDD; cd11961; SH3_Abp1_fungi_C2; 1.
DR Gene3D; 3.40.20.10; -; 1.
DR InterPro; IPR035718; Abp1_fungi_SH3_C2.
DR InterPro; IPR002108; ADF-H.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00102; ADF; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF50044; SSF50044; 2.
DR PROSITE; PS51263; ADF_H; 1.
DR PROSITE; PS50002; SH3; 2.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; SH3 domain.
FT CHAIN 1..857
FT /note="Protein app1"
FT /id="PRO_0000064640"
FT DOMAIN 6..133
FT /note="ADF-H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
FT DOMAIN 725..785
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 800..857
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 167..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..562
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 91138 MW; 247EFA78BAFE7097 CRC64;
MSFQLDTSTH GAEIRNVYEK VLSGADDCSW AIFGYEKGQG NILKVVASGN DNDEFLDEFD
ENAVLFGFLR VKDVNTGLNK FVLVCWCGEA AARKGLFSIH MATVSNLLKG YHVQITGRES
SDLNMDDIIR RVADASGSKY SVHTSNSTPQ SKHNAFYDAS QTFGSTAKVA PAPAPSTKTP
LANISKPVVQ AQKDSKDNSW DDSSKQSNTQ TANTTSNLRV PVNASWSDAG RKEKSQENKP
KPTPFGSGGP SKPTPFESHG PAKQISVQPS EHPKPSISTT TTGSSYRSAE SSHAPTTPDH
FKLTPLTKLE PQPPSGSPSK KPVSELEELH TAGNVNLSAR RALFEKKESS TKNVENPVSH
HLKSPVRTSF PPASTTASKQ DSPSTVPVDK QETAKPINKQ VSSNETSAQE EPRESVAALR
ARFAKANVSE NNDPPTFPKT AAKISSFNSK AGTSFAKPRP FTNNPNPISA PEKPTSGESL
SLNPPPAMPK VFPERDISSA SQKAAQPSVI TPSVPQPPAA PVVPEAPSVH QPPAAPVAPE
VPSAPQRPAA PVVPEAPSVP QRPAVPVVPE ALSVPQPPVA PVAPEVPSVP QPPVAPVVPE
APSVPQPPVA PVAPEVPSVP QRPAVPVVPE APSVPQPPAA PVVPEVPSVP QRPAVPVVPE
APSVPQPPAA PVVPEVPSVP QPPAVPVVPE AGQLNEPVVP PLPPHDETQE PQVGGDVKAT
EHTQPTKTPA IVIYDYSPEE ENEIELVENE QIQILEFVDD GWWLGENSKG QQGLFPSNYV
EITGPNETAN NPPAEPQAGG PGKSVKAIYD YQAQEDNELS FFEDEIIANV DCVDPNWWEG
ECHGHRGLFP SNYVEEI
