ID   IQAK1_HUMAN             Reviewed;         560 AA.
AC   A8MXQ7; A0A1B0GTG1;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-AUG-2020, sequence version 3.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=IQ motif and ankyrin repeat domain-containing protein 1 {ECO:0000305};
GN   Name=IQANK1 {ECO:0000312|HGNC:HGNC:49576};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC105219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A8MXQ7; -.
DR   SMR; A8MXQ7; -.
DR   IntAct; A8MXQ7; 1.
DR   MINT; A8MXQ7; -.
DR   PhosphoSitePlus; A8MXQ7; -.
DR   BioMuta; -; -.
DR   BioMuta; IQANK1; -.
DR   MassIVE; A8MXQ7; -.
DR   PeptideAtlas; A8MXQ7; -.
DR   PRIDE; A8MXQ7; -.
DR   Ensembl; ENST00000527139.7; ENSP00000489685.1; ENSG00000203499.12.
DR   MANE-Select; ENST00000527139.7; ENSP00000489685.1; NM_001381874.1; NP_001368803.1.
DR   GeneCards; IQANK1; -.
DR   HGNC; HGNC:49576; IQANK1.
DR   HPA; ENSG00000203499; Tissue enhanced (esophagus, skin).
DR   MIM; 618942; gene.
DR   neXtProt; NX_A8MXQ7; -.
DR   OpenTargets; ENSG00000203499; -.
DR   VEuPathDB; HostDB:ENSG00000203499; -.
DR   GeneTree; ENSGT00390000010763; -.
DR   OMA; DGPEYGP; -.
DR   PathwayCommons; A8MXQ7; -.
DR   SignaLink; A8MXQ7; -.
DR   ChiTaRS; IQANK1; human.
DR   Pharos; A8MXQ7; Tdark.
DR   PRO; PR:A8MXQ7; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; A8MXQ7; protein.
DR   Bgee; ENSG00000203499; Expressed in right uterine tube and 95 other tissues.
DR   ExpressionAtlas; A8MXQ7; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:2000812; P:regulation of barbed-end actin filament capping; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS50096; IQ; 1.
PE   4: Predicted;
KW   ANK repeat; Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..560
FT                   /note="IQ motif and ankyrin repeat domain-containing
FT                   protein 1"
FT                   /id="PRO_0000343881"
FT   DOMAIN          62..91
FT                   /note="IQ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   REPEAT          191..223
FT                   /note="ANK 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          224..253
FT                   /note="ANK 2"
FT                   /evidence="ECO:0000255"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          281..398
FT                   /evidence="ECO:0000255"
FT   VARIANT         465
FT                   /note="T -> R (in dbSNP:rs4875053)"
FT                   /id="VAR_044540"
SQ   SEQUENCE   560 AA;  63562 MW;  78B9EA3CFAD943A8 CRC64;
     MDSKKGRPKA AAGKWQTLHP GPKTRAAAGK PGENRPPQRK AGWQAREPAS AESPQAPTGP
     AEDRAARAIQ GAFRQLRARR ELARRREERR EYLEQMETPQ KEAYLAPVRR EQEAARRLRE
     QEEAAQRERR EELQRRRRLL DAAFDGDVGE IRAVLKEVEQ LLTREGVGHD EAGEARRLQR
     RVALAECEDS YGNTPLSEAA AGGQPLAIQL RAELGASPNS KGAFGPTPLY RAAFGGHLAA
     VEVLLKLGAD PRVYAEDGST PERVASLDTV VSVLRSWDLS LTEAMLQNME AEQQRRAQEA
     QRHKEAEAER CGSMTLKVQQ LTREQQQCHK ELQQAYCELS RRISEHDQCE WRCMDKTKLT
     LQAIKDTEAQ VDRLRQEAQK AEEALAMARL ELREQTQEGE EEAPGLKCQV TELHDVLMKD
     VGNRIRADGR WPLVIDPLGQ AATFLRYQDT NYVDTVNPEP LRPETMWLAL LGALRYGKPL
     VFDLREEDLF PVVQRQLEAV QERYLSLLRP TDGPEYSPTQ FQEQRLEHFR LFFVTKVQWP
     PAEQLQVLLP VRVQLPGTGL