IQAK1_MOUSE
ID IQAK1_MOUSE Reviewed; 540 AA.
AC Q3TYL0; A0A140LHX0;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-AUG-2020, sequence version 3.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=IQ motif and ankyrin repeat domain-containing protein 1 {ECO:0000305};
GN Name=Iqank1 {ECO:0000312|MGI:MGI:3588184};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE34553.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AC116487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK158547; BAE34553.1; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q3TYL0; -.
DR SMR; Q3TYL0; -.
DR STRING; 10090.ENSMUSP00000140297; -.
DR iPTMnet; Q3TYL0; -.
DR PhosphoSitePlus; Q3TYL0; -.
DR PRIDE; Q3TYL0; -.
DR ProteomicsDB; 320202; -.
DR UCSC; uc007wie.1; mouse.
DR MGI; MGI:3588184; Iqank1.
DR VEuPathDB; HostDB:ENSMUSG00000102018; -.
DR eggNOG; KOG4177; Eukaryota.
DR InParanoid; Q3TYL0; -.
DR PhylomeDB; Q3TYL0; -.
DR ChiTaRS; Iqank1; mouse.
DR PRO; PR:Q3TYL0; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q3TYL0; protein.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..540
FT /note="IQ motif and ankyrin repeat domain-containing
FT protein 1"
FT /id="PRO_0000343882"
FT DOMAIN 62..91
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REPEAT 191..220
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 224..253
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 281..388
FT /evidence="ECO:0000255"
FT COMPBIAS 41..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 540 AA; 60994 MW; BF22365BDE1814FA CRC64;
MSTKKGGPKA ASGKGQALLP GSKLRATAGK PRESRQLQRK ASHPSKGSFS ENPQAPAAPT
AEDKAAIVIQ CAFRQYLARR ELARRCQERQ EYLDEMEKLQ KEAYLALVRQ EQEAARRQRE
KEEAEERARR EELQRRRRLL EAAFEGDLGE IRQVLKEVEQ LMTREGVGYD EDGKARRLQR
RVATVECEDS HGNTPLSEAA AGGQTMAIQL LAELGANPNT KGAFGRTPLY RAAFGGHLEA
VEELLKIGAD PRMYADDGST PEQVASLAAV ASVLQSWDLS LTEAMLKNME AEQQRRAQEA
QKHKENEAKR INIKVQQLAK EQQKCQKELQ QAYCELNRRI MEHDKCERKF MGNTELTLQA
IKDAEAQVDR LQQEAQKAEE TLAMARLELR EQTPEDEDTE PGLKCRVTEL HDVLMKDVGD
RIRADGRWPL VIDPSGQAAT FLRYQDTNYV DTLNPEHLRP ERIRLALLGA LRYGKPLVFD
LRQVNLFPVV QQQLEVVQTG LAQALLNRGL LAKEGYLSLL RPTDGPEYDP SQFQEARLEN
