IQCAL_HUMAN
ID IQCAL_HUMAN Reviewed; 818 AA.
AC A6NCM1; A0A087WYV2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=IQ and AAA domain-containing protein 1-like;
DE AltName: Full=IQ and AAA domain-containing protein 1 pseudogene 1;
GN Name=IQCA1L; Synonyms=IQCA1P1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR EMBL; AC010973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS78288.1; -.
DR RefSeq; NP_001291348.1; NM_001304419.1.
DR AlphaFoldDB; A6NCM1; -.
DR SMR; A6NCM1; -.
DR IntAct; A6NCM1; 2.
DR STRING; 9606.ENSP00000482119; -.
DR PhosphoSitePlus; A6NCM1; -.
DR BioMuta; IQCA1L; -.
DR jPOST; A6NCM1; -.
DR MassIVE; A6NCM1; -.
DR PeptideAtlas; A6NCM1; -.
DR PRIDE; A6NCM1; -.
DR ProteomicsDB; 845; -.
DR DNASU; 392843; -.
DR Ensembl; ENST00000615129.4; ENSP00000482119.1; ENSG00000278685.4.
DR GeneID; 392843; -.
DR KEGG; hsa:392843; -.
DR MANE-Select; ENST00000615129.4; ENSP00000482119.1; NM_001304419.2; NP_001291348.1.
DR CTD; 392843; -.
DR DisGeNET; 392843; -.
DR GeneCards; IQCA1L; -.
DR HGNC; HGNC:22831; IQCA1L.
DR HPA; ENSG00000278685; Tissue enriched (testis).
DR neXtProt; NX_A6NCM1; -.
DR VEuPathDB; HostDB:ENSG00000278685; -.
DR eggNOG; KOG0740; Eukaryota.
DR GeneTree; ENSGT00940000154067; -.
DR InParanoid; A6NCM1; -.
DR OMA; MKHRMDQ; -.
DR OrthoDB; 127946at2759; -.
DR PhylomeDB; A6NCM1; -.
DR PathwayCommons; A6NCM1; -.
DR SignaLink; A6NCM1; -.
DR BioGRID-ORCS; 392843; 1 hit in 86 CRISPR screens.
DR ChiTaRS; IQCA1L; human.
DR GenomeRNAi; 392843; -.
DR Pharos; A6NCM1; Tdark.
DR PRO; PR:A6NCM1; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A6NCM1; protein.
DR Bgee; ENSG00000278685; Expressed in left testis and 35 other tissues.
DR ExpressionAtlas; A6NCM1; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00015; IQ; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..818
FT /note="IQ and AAA domain-containing protein 1-like"
FT /id="PRO_0000341249"
FT DOMAIN 206..235
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 344..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 567..574
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 818 AA; 95061 MW; 8B3BE1F1E5179DFD CRC64;
MSEGAYQRLW ESSHATLQEL LDQEQLLLEP APDRERQSFQ YRLASLYLHY LGLLRRFDTV
YDQMVQPQKR RLLRRLLDGV AGRVLELKDE LVRADLCENH CLDRVLQDFK LTPADLEVPI
PKYFLLEQST TVRERGLILA EILSRLEPVS SQKSFTGMHR TEAIILVQKA ERARQGRLRA
TFMREIRRDE EQDGRIREDG WHKFSQGQAA VTIQKVWKGY LQRKRTQQDR RMEMEFIGML
PSPNQVEHLS IISQPCLVED VQRLRQMEKE EEFRAAMVKA HDSLVETEGP DMKEKMKEQI
RQWFIECHDL TGRFPDYPDA SSGGSYSIFA DKTPEQVRME LEMQMQENRK KEQEKSKEKG
KDEKEKKKGK EEKAKKGEVD AVLQVLPSKC IPMICAGHEE YLNTWKNRCE SIHPSQNYDS
ETLREEKRKE VELEIRIQVD ELMRQELRKL RLAVDKEEER PLRAPKKTPG KKTGKKKEKD
LTSDRSVESL YEELVISGLL RKSESVALKD YIGDFLYLGS TLSLVKKLPM PSLFDIRQNV
ALYAVLRLGS PDIHIMAPLI RSILLVGPSG MGKKMLVKAV CTETGANLFD LSPENLLGKY
PGRNGAQMMV HIVFKVARLL QPSVIWIGNA EKNFYKKTPK EDKEMDPKRI KKDLTKALRL
LTPGDRVMLI GTTSRPQLAE MRGLCRVYER ILFMPRPDYA SRYVLWKRMI EARGIQPTQH
LDISALAKVS DGYTPGHILQ AIQSVLSERR FLQLSKRPLV ASEFLGQLVK LDPVYREEEE
SLKDWYFKTP LGKKSMKHRM DQLEAEEAKL DKEKKKRK
