IQCAL_MOUSE
ID IQCAL_MOUSE Reviewed; 825 AA.
AC A6H690; B9EHI7; E9QN17; Q8CDM7;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=IQ and AAA domain-containing protein 1-like;
DE AltName: Full=Protein IQCA1P1;
GN Name=Iqca1l; Synonyms=Iqca1p1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6H690-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6H690-2; Sequence=VSP_034231;
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC26640.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC26640.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK029839; BAC26640.1; ALT_SEQ; mRNA.
DR EMBL; AC116136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137999; AAI38000.1; -; mRNA.
DR EMBL; BC145792; AAI45793.1; -; mRNA.
DR CCDS; CCDS51435.1; -. [A6H690-1]
DR RefSeq; NP_808344.3; NM_177676.6. [A6H690-1]
DR AlphaFoldDB; A6H690; -.
DR SMR; A6H690; -.
DR STRING; 10090.ENSMUSP00000085642; -.
DR iPTMnet; A6H690; -.
DR PhosphoSitePlus; A6H690; -.
DR EPD; A6H690; -.
DR PaxDb; A6H690; -.
DR PeptideAtlas; A6H690; -.
DR PRIDE; A6H690; -.
DR ProteomicsDB; 269500; -. [A6H690-1]
DR ProteomicsDB; 269501; -. [A6H690-2]
DR DNASU; 231045; -.
DR Ensembl; ENSMUST00000088302; ENSMUSP00000085642; ENSMUSG00000038199. [A6H690-1]
DR GeneID; 231045; -.
DR KEGG; mmu:231045; -.
DR UCSC; uc008wrz.2; mouse. [A6H690-1]
DR CTD; 392843; -.
DR MGI; MGI:3045319; Iqca1l.
DR VEuPathDB; HostDB:ENSMUSG00000038199; -.
DR eggNOG; KOG0740; Eukaryota.
DR GeneTree; ENSGT00940000154067; -.
DR HOGENOM; CLU_005923_0_0_1; -.
DR InParanoid; A6H690; -.
DR OMA; MKHRMDQ; -.
DR OrthoDB; 127946at2759; -.
DR PhylomeDB; A6H690; -.
DR TreeFam; TF324350; -.
DR BioGRID-ORCS; 231045; 3 hits in 71 CRISPR screens.
DR PRO; PR:A6H690; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; A6H690; protein.
DR Bgee; ENSMUSG00000038199; Expressed in testis and 10 other tissues.
DR ExpressionAtlas; A6H690; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00612; IQ; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..825
FT /note="IQ and AAA domain-containing protein 1-like"
FT /id="PRO_0000341250"
FT DOMAIN 206..235
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 344..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 572..579
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..385
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_034231"
FT CONFLICT 788
FT /note="S -> T (in Ref. 1; BAC26640)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 825 AA; 95956 MW; E48D76DDA7AB7453 CRC64;
MSEGTYQRLW EASHVTLEEV LEKEPSVLEP VPSRERQSFQ YRISVLYLYY LGLLRRFNLA
YDQMVQPQKR RLLRRLLDGV AGRVLELKDE LVRVDLCETH CLDRVLQDLK LTPADLEVPI
PKYFQLEQSS AVKARQQMLA DILNRLEPLV SQENLRGLSR TAALILVQSA ERARQGRLRA
TFMREIRKEE ERDRRIWENG QQKFSRDQGA IVIQKVWKGY LQRKRIEQDR RVEMEFIGML
PSPNQTARLN TLNQAFLGEE SRRMRQVEKE EEFQEAIGKT YESLTETEGP DMKERMKDQI
RQWFIECHAL TGRFPDYPDE ASGGSYLIFA DKTPEQVRLD LEAQAQESRK KDQEKKEKNK
EKEKEKKEKK KKKVKEEKVK KEPEVMFRVL PSKSIPVINA GHEEYTSVWK SRYDNKHPSQ
NFDSETLREE KRKQVEMEIR VQVDELMRQE LKNLRLAVDR EETRPLKSPK KKGGKKSGKK
KKEKDLTPDR SVDSLFEELV IIGLIKKSAL VTLSDYIGDC LYLGSTLTLA NKMPMPSLFD
IRQNMALYGV LRLGSHDIHT MAPLVRSILL VGPSGMGKKM LVQAVCTETG ANLFDLSPDN
LMGKYPGKNG AQLLVHIVFK VARLLQPSVI WIGNTEKTFY KKVPKEERTM DPKRIKKDLM
RATKQLSPGD RVMLIGTTER PQLAEMKGLC RFYERILFIP RPDYASRYVL WKRMIESQGR
GVQLTSSLDV SALARVSDGY TPSHILQSIQ SVLTERRLLQ LIKKPLVASE FVGHLARLDP
VYREEEESLK EWFFKTPLGK KNMKFTKDQL EAEEARLTKE KKKKK
