IQCAL_RAT
ID IQCAL_RAT Reviewed; 822 AA.
AC Q6AXQ7;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=IQ and AAA domain-containing protein 1-like;
DE AltName: Full=Protein IQCA1P1;
GN Name=Iqca1l; Synonyms=Iqca1p1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6AXQ7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6AXQ7-2; Sequence=VSP_034232;
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AABR03033522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC079392; AAH79392.1; -; mRNA.
DR AlphaFoldDB; Q6AXQ7; -.
DR SMR; Q6AXQ7; -.
DR STRING; 10116.ENSRNOP00000014998; -.
DR PhosphoSitePlus; Q6AXQ7; -.
DR PaxDb; Q6AXQ7; -.
DR PRIDE; Q6AXQ7; -.
DR RGD; 1564789; Iqca1l.
DR eggNOG; KOG0740; Eukaryota.
DR InParanoid; Q6AXQ7; -.
DR PhylomeDB; Q6AXQ7; -.
DR PRO; PR:Q6AXQ7; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00612; IQ; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50096; IQ; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..822
FT /note="IQ and AAA domain-containing protein 1-like"
FT /id="PRO_0000341251"
FT DOMAIN 206..235
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 338..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 569..576
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..382
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034232"
SQ SEQUENCE 822 AA; 95625 MW; 1B76A3A2B02969F6 CRC64;
MSEGTYQRLW EASHATLEEV LEKEPSPLEP VLTRERQSFQ YRISVLYLYY LGLLRRFNLA
YDQMVQPQKR RLLRRLLDGV AGRVLELKDE LVRVDLCETH CLDRVLQELK LTPVDLEVPI
PKYFQLEQTS TMKARQQMLA EILARLEPLA SQENLRGMSR TEALIIVQCA ERARQGRLRA
TFMREIRKEE ERDRRIRENG RQKFSQDQGA IVIQKVWKGY LQRKRIEQDR RMEMEFIGML
PSSSQTTRQN ALAQAFVGEE SRRTRQVEKE EEFQEAIAKT HESLTETEGP DMKERMKDQI
RQWFIECHAL TGRFPDYPDE ASGGSYLIFA DKTPEQVRQE LEAQAQENKK KEQEKNKDKV
KEKKEKKKKK TKEEKAKKDP EVMFKVLPSK SIPVINAGHE EFTSIWKSRY DNKHPSQSFD
SETLREEKRK QVEMEIRVQV DELMRQELRN LRLAVDREET RPLKSPKKKG GKKSGKKKKE
KDLTPDRSVD SLFEELVVIG LIKKSLLVTL NDYIGDCLYL GSTLTLANKI PMPSLFDIRQ
NIALYGVLRL GSHDIHTMAP LVRSILLVGP SGMGKKMLVQ AVCTETGANL FDLSPGNVMG
KYPGKNGSQL LMHIVFKVAR VFQPSVIWIG NTEKTFYKKI PKEERRMDPK RIKKDLMRAT
RQLGPGDRVM LIGTTERPQL AEMKGLCRFY ERILFIPRPD YASRYVLWKR MIENQGIGVQ
QTQSLDISAL ARVSDGYTPG HILQSIQSVL TERRLLQLTK KPLVASEFVV HLAKLDPVYR
EEEESLKEWF YKTPLGKKNI KFTKDQQEAE EARLAKEKKK KK
